Spiky gold shells on magnetic particles for DNA biosensors

Bedford, Erin; Boujday, Souhir; Pradier, Claire‐Marie; Gu, Frank

doi:10.1016/j.talanta.2018.01.094

Cited by 15 publications

(7 citation statements)

References 62 publications

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“…For example, the plasmonic properties of nanorods depend very much on the ratio of the semi axes and head shape, 69 while the characterization of nanostars and nanofingers have to consider the tips and the center parts at the same time. 29 On the other hand, core-shell structures, 65,[70][71][72] can be considered as a single sphere with an equivalent radius. 73 3.3.2.…”

Section: Structuresmentioning

confidence: 99%

Are plasmonic optical biosensors ready for use in point-of-need applications?

Liu

Jalali

Mahshid

et al. 2020

Analyst

150

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Plasmonics has drawn significant attention in the area of biosensors for decades due to the unique optical properties of plasmonic resonant nanostructures. While the sensitivity and specificity of molecular detection relies significantly on the resonance conditions, significant attention has been dedicated to the design, fabrication, and optimization of plasmonic substrates. The adequate choice of materials, structures, and functionality goes hand in hand with a fundamental understanding of plasmonics to enable the development of practical biosensors that can be deployed in real life situations. Here we provide a brief review of plasmonic biosensors detailing most recent developments and applications. Besides metals, novel plasmonic materials such as graphene are highlighted. Sensors based on Surface Plasmon Resonance (SPR), Localized Surface Plasmon Resonance (LSPR), and Surface Enhanced Raman Spectroscopy (SERS) are presented and classified based on their materials and structure. In addition, most recent applications to environment monitoring, health diagnosis, and food safety are presented. Potential problems related to the implementation in such applications are discussed and an outlook is presented. Fundamentals of plasmonic materialsPlasmonics studies the interaction of light with metals or metallic nanostructures. Other materials such as graphene also exhibit plasmonic resonance due to the availability of con-

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Section: Structuresmentioning

confidence: 99%

Are plasmonic optical biosensors ready for use in point-of-need applications?

Liu

Jalali

Mahshid

et al. 2020

Analyst

150

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“…Anisotropic spiky nanoparticles, such as gold nanostars [ 108 , 109 ] and nanoflowers [ 110 ], can generate intense electromagnetic field at their tips, which is similar to the lightning rod effect [ 111 ]. The strong localized fields at the tips enable this nanostructure with great potential for surface-enhanced Raman spectroscopy (SERS) [ 112 , 113 ], surface plasmon resonance platform for (bio)molecule detection [ 114 ], and/or nonlinear optical applications [ 115 , 116 ]. Compared to others, spiky nanoparticles have larger extinction cross section in the near-infrared (NIR) region, and as a consequence, photothermal heating capacity is greater than non-spiky nanoparticles, and it makes them a good candidate for diagnostic and therapeutic applications.…”

Section: Other Types Of Gold Nanoshellsmentioning

confidence: 99%

Synthetic Methodologies to Gold Nanoshells: An Overview

et al. 2018

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Gold nanostructures that can be synthetically articulated to adapt diverse morphologies, offer a versatile platform and tunable properties for applications in a variety of areas, including biomedicine and diagnostics. Among several conformational architectures, gold nanoshells provide a highly advantageous combination of properties that can be fine-tuned in designing single or multi-purpose nanomaterials, especially for applications in biology. One of the important parameters for evaluating the efficacy of gold nano-architectures is their reproducible synthesis and surface functionalization with desired moieties. A variety of methods now exist that allow fabrication and chemical manipulation of their structure and resulting properties. This review article provides an overview and a discussion of synthetic methodologies to a diverse range of gold nanoshells, and a brief summary of surface functionalization and characterization methods employed to evaluate their overall composition.

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“…Besides, magnetic particles coated with nanostructured plasmonic shells have also been fabricated. This unique structure integrates magnetic separation and SERS detection, showing excellent performance for DNA analysis 85 .…”

Section: Introductionmentioning

confidence: 99%

SERS Tags for Biomedical Detection and Bioimaging

Liu¹,

Gao²,

Xu³

et al. 2022

Theranostics

163

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Surface-enhanced Raman scattering (SERS) has emerged as a valuable technique for molecular identification. Due to the characteristics of high sensitivity, excellent signal specificity, and photobleaching resistance, SERS has been widely used in the fields of environmental monitoring, food safety, and disease diagnosis. By attaching the organic molecules to the surface of plasmonic nanoparticles, the obtained SERS tags show high-performance multiplexing capability for biosensing. The past decade has witnessed the progress of SERS tags for liquid biopsy, bioimaging, and theranostics applications. This review focuses on the advances of SERS tags in biomedical fields. We first introduce the building blocks of SERS tags, followed by the summarization of recent progress in SERS tags employed for detecting biomarkers, such as DNA, miRNA, and protein in biological fluids, as well as imaging from in vitro cell, bacteria, tissue to in vivo tumors. Further, we illustrate the appealing applications of SERS tags for delineating tumor margins and cancer diagnosis. In the end, perspectives of SERS tags projecting into the possible obstacles are deliberately proposed in future clinical translation.

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Spiky gold shells on magnetic particles for DNA biosensors

Cited by 15 publications

References 62 publications

Are plasmonic optical biosensors ready for use in point-of-need applications?

Are plasmonic optical biosensors ready for use in point-of-need applications?

Synthetic Methodologies to Gold Nanoshells: An Overview

SERS Tags for Biomedical Detection and Bioimaging

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