Spilanthol: occurrence, extraction, chemistry and biological activities

Barbosa, Alan Franco; Carvalho, Mário Geraldo de; Smith, Robert E.; Sabaa-Srur, Armando U. O.

doi:10.1016/j.bjp.2015.07.024

Cited by 99 publications

(89 citation statements)

References 50 publications

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“…Comparando os dois resultados, o extrato de agrião-bravo apresentou cerca de quatro vezes menos espilantol que o extrato de jambu. Esses resultados são inovadores, uma vez que dados sobre quantificação de espilantol descritos na literatura são apresentados em mg/mL como se fossem concentrações de padrões dissolvidos em solventes, não havendo menção de concentrações de espilantol em unidades de µg de espilantol/mg de amostra (BARBOSA et al, 2015).…”

Section: Figura 2 -Cromatograma Do Extrato Etanólico Das Partes áReasunclassified

“…O Espilantol é uma N-alquilamida alifática, encontrada principalmente no jambu (Spilanthes acmella (L.) Mur., Asteraceae), herbácea nativa da região norte do Brasil, onde é utilizada em pratos típicos da culinária Paraense e como analgésico contra dores de dente. Várias atividades biológicas são descritas na literatura para o espilantol, tais como anestésico, acaricida e anti-rugas, sendo por isso destaque na indústria de medicamentos, alimentos e cosméticos (BARBOSA et al, 2015). Existem cerca de 30 patentes registradas no mundo todo com produtos a base de espilantol (HAW & KENG, 2003 (BARBOSA et al, 2015).…”

Section: Introductionunclassified

“…Várias atividades biológicas são descritas na literatura para o espilantol, tais como anestésico, acaricida e anti-rugas, sendo por isso destaque na indústria de medicamentos, alimentos e cosméticos (BARBOSA et al, 2015). Existem cerca de 30 patentes registradas no mundo todo com produtos a base de espilantol (HAW & KENG, 2003 (BARBOSA et al, 2015).…”

Section: Introductionunclassified

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Quantificação de espilantol em extratos de jambu (Spilanthes acmella (L.) Mur.) e agrião-bravo (Acmella uliginosa (S.) Cass)

Souza¹,

Silva²,

Ribeiro³

et al. 2017

II Encontro Do Programa De Pós-Graduação Em Ciências Farmacêuticas Da Universidade Federal Do Ceará E I Simpósio Norte-Nordeste

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Section: Figura 2 -Cromatograma Do Extrato Etanólico Das Partes áReasunclassified

Section: Introductionunclassified

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Quantificação de espilantol em extratos de jambu (Spilanthes acmella (L.) Mur.) e agrião-bravo (Acmella uliginosa (S.) Cass)

Souza¹,

Silva²,

Ribeiro³

et al. 2017

II Encontro Do Programa De Pós-Graduação Em Ciências Farmacêuticas Da Universidade Federal Do Ceará E I Simpósio Norte-Nordeste

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“…In addition, Barbosa et al (2016) stated that spilanthol, a substance found in jambu, has aroused the interest of pharmaceutical and cosmetic markets due to its biological activities such as analgesic, antinociceptive, antioxidant, anti-inflammatory, antimutagenic, antiwrinkle, antifungal, bacteriostatic, insecticidal, antimalarial, anti-larvicidal against Aedes aegypti and Helicoverpa zea neonates, and anti-molluscicide. It can be absorbed through the skin, endothelial intestine, oral mucosa, and blood-brain barrier.…”

Section: Introductionmentioning

confidence: 99%

Productivity of Irrigated Jambu Under Soil-Water Stresses and Nitrogen Doses

et al. 2020

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Jambu (Acmella oleracea (L.) R.K.) is a short-cycle leafy vegetable from the Amazon region, which needs an adequate availability of water and nutrients, mainly nitrogen, to obtain a rapid mass increase. This research aimed to study the effect of different soilwater stresses and nitrogen doses on jambu cultivation in the state of Pará. The experiments were conducted at the Igarapé-Açu experimental farm of the Federal Rural University of Amazonia (UFRA). The Jamburana variety was used in a 10 × 10 cm spacing, using a randomized block design in a 4 × 4 factorial scheme with three replications. Each plot had a dimension of 0.4 × 0.5 m (0.2 m 2 ), totaling 20 plants in 4 rows, but only the plants of the central rows were useful. Treatments consisted of four soil-water stresses (12, 18, 24, and 30 kPa) as an indication of the irrigation time (critical stress), using drip irrigation, and four nitrogen doses (0, 50, 100, and 150 kg ha −1 ). The use of soil-water stress of 12 kPa associated with nitrogen fertilization at a dose of 150 kg ha −1 is recommended for better development and production of jambu under the conditions this experiment was conducted.

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“…A sensação anestésica deve-se à presença do espilantol (BARBOSA et al , 2016), um composto bioativo do grupo químico das alquilamidas com diversas propriedades farmacológicas. Tal substância tem sido estudada pela indústria de fármacos e de cosméticos, sendo usada como constituinte de cremes para combate a expressões de idade e de pomadas que substituem a anestesia em processos odontológicos (HOMMA et al, 2014;BARBOSA et al, 2016). Estudos recentes têm comprovado que o jambu, devido à presença do espilantol, pode apresentar diversas propriedades farmacológicas, como capacidade anti-inflamatória, analgésica, antioxidante, antipirética, inseticida, diurética e afrodisíaca (DUBEY et al, 2013;PRACHAYASITTIKUL et al, 2013;BARBOSA et al, 2016).…”

Section: Introductionunclassified

AVALIAÇÃO DA PRODUÇÃO DE FITOMASSA E SINTOMAS DE DEFICIÊNCIA NA CULTURA DO JAMBU [ Acmella oleracea (l.) R. K. Jansen] CULTIVADO SOB OMISSÃO DE MACRONUTRIENTES E FERRO

Trindade¹,

Filho²,

Farias³

et al. 2019

Democratização Do Conhecimento E Valorização Profissional: Caminhos Para O Desenvolvimento Tecnológico E Social

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The jambu [Acmella oleracea (L.) R. K. Jansen] has northern Brazil as one of its centers of origin. This vegetable is widely consumed in regional cuisine, and has been gaining ground mainly for its medicinal properties. In spite of the big interest for its biological qualities, there are few studies that deal with its nutritional management as well as the possible disorders generated from the lack of a particular nutrient. The aim of this study was to evaluate the effects of macronutrient and iron omission on nutrient omission of jambu plants, characterizing the visual deficiency symptoms produced by the plants, evaluating air and root dry mass production data. The experiment was conducted in a greenhouse. The statistical design was completely randomized with eight treatments and five repetitions. The plants were grown in complete solution containing all the nutrients until the beginning of flowering, and from that moment, the treatments were applied: Complete Solution, Nitrogen Omission, Phosphorus Omission, Potassium Omission, Calcium Omission, Magnesium Omission, Sulfur omission and iron omission. Solutions were applied daily and plant evaluations were performed to characterize the deficiency symptoms. The plants were collected 35 days after the beginning of the treatments and the shoot and root dry matter were evaluated, as well as the description of the symptoms observed during the experiment. At the time of collection, the material was separated into aerial and root parts, the materials were identified, placed in a Kraft paper bag and sent to the IFPA soil laboratory. The material was oven dried at 65C for 72 hours until it reached a constant mass. When removing the material from the kiln, digital scale weighing was performed. After that the data were tabulated and the statistical software IBM SPSS was used to perform the statistical analyzes. The omission allowed the visualization of symptoms of deficiency. With this it was possible to verify the limitation to plant growth with the worsening of symptoms, especially in the treatment with potassium omission, which was the most limiting treatment to the growth of the crop. In decreasing order the treatments that most limited the growth of the culture were: Potassium> Nitrogen> Calcium> Phosphorus> Magnesium> Sulfur> Iron. Therefore, nutrient omission provides an important tool for visualizing nutritional deficiencies.

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Spilanthol: occurrence, extraction, chemistry and biological activities

Cited by 99 publications

References 50 publications

Quantificação de espilantol em extratos de jambu (Spilanthes acmella (L.) Mur.) e agrião-bravo (Acmella uliginosa (S.) Cass)

Quantificação de espilantol em extratos de jambu (Spilanthes acmella (L.) Mur.) e agrião-bravo (Acmella uliginosa (S.) Cass)

Productivity of Irrigated Jambu Under Soil-Water Stresses and Nitrogen Doses

AVALIAÇÃO DA PRODUÇÃO DE FITOMASSA E SINTOMAS DE DEFICIÊNCIA NA CULTURA DO JAMBU [ Acmella oleracea (l.) R. K. Jansen] CULTIVADO SOB OMISSÃO DE MACRONUTRIENTES E FERRO

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