Spin and dip coating of light-emitting polymer solutions: Matching experiment with modelling

Yimsiri, Piyachat; Mackley, M. R.

doi:10.1016/j.ces.2005.12.018

Cited by 150 publications

(94 citation statements)

References 34 publications

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“…comparing to F9,B1 with (15%kol.+0.3% xan.) which might be attributed to the reduction in the viscosity of the coating dispersion in these formulas, an effect which withdrawal that reduces the volume of the liquid deposited on the tablet surface leading to a thinner film layer 29,30,31 . On the other hand, the significant increase in the coated tablet weight and thickness which were detected in OST formulas F12,F13,B4 and B5 double and triple coated respectively with (15% kol.+0.3% xan.)…”

Section: Pre-compression and Post-compression Parameters Of The Prepamentioning

confidence: 99%

New Easily Swallowed Tablets with Slippery Coating for the Antihypertensive Drug Valsartan

Mahdi

Maraie

2015

PBJ

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Different tablet dosage forms were prepared to be administered for patients with dysphagia (swallowing difficulties) like buccal, sublingual and orodispersible tablets, however, they possesses certain constrains like taste masking difficulties, limitations in drug and dose selection and friability. Hence, in an attempt to overcome these constrains, a new easily swallowed immediate release tablets containing (160mg) Valsartan were prepared, and designed to be slippery upon contact with saliva giving an easy swallowing of the intact tablet (without water) with efficient taste masking effect, thus, they called Oroslippery tablets (OSTs). Core tablets were prepared by direct compression using different superdisintegrants, followed by dipping in special coating dispersion containing different proportion of kollicoat IR (film former) and xanthan gum (slipperiness inducer) at different coating levels. These OSTs were optimized for their physical properties, in-vitro disintegration and release in addition to in-vivo slipperiness and taste masking effect. It was found that F12 containing 6% crosscarmellose sodium double coated with 15% kollicoat IR and 0.3% xanthan gum possessed a good mechanical strength (hardness=5.69±0.58 Kg/cm 2 , friability=0.09%±0.79), suitable in-vivo slipperiness and taste masking times (8±1.45 and 58±2.18 seconds) respectively, with longer disintegration time (5.57±1.36 minutes) but similar release profile to the commercial conventional tablet Diovan ® with similarity factor (f2= 68.4±1.07) and difference factor (f1= 1.39± 0.95). Therefore, this study developed a new easily swallowed tablet with an efficient taste masking property, high loading capacity and adequate mechanical strength that can be used as an alternative to buccal, sublingual and orodispersible tablets.

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Section: Pre-compression and Post-compression Parameters Of The Prepamentioning

confidence: 99%

New Easily Swallowed Tablets with Slippery Coating for the Antihypertensive Drug Valsartan

Mahdi

Maraie

2015

PBJ

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“…Fields in which smart or stimuli-responsive coatings are applied range from computer chips [2], hard disk manufacturing [3], to biomedical and aviation applications [4,5]. Many different techniques have been developed for the fabrication of protective and nanostructured coatings such as spin-coating [6], dip-coating [7], layer-by-layer [8], and drop casting [9]. However in these processes, the physically adsorbed polymer films can be easily desorbed or delaminated from the surface under unfavorable conditions.…”

Section: Introductionmentioning

confidence: 99%

RAFT “grafting-through” approach to surface-anchored polymers: Electrodeposition of an electroactive methacrylate monomer

et al. 2011

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Abstract. The synthesis of homopolymer and diblock copolymers on surfaces was demonstrated using electrodeposition of a methacrylate-functionalized carbazole dendron and subsequent reversible additionfragmentation chain transfer (RAFT) "grafting-through" polymerization. First, the anodically electroactive carbazole dendron with methacrylate moiety (G1CzMA) was electrodeposited over a conducting surface (i.e. gold or indium tin oxide (ITO)) using cyclic voltammetry (CV). The electrodeposition process formed a crosslinked layer of carbazole units bearing exposed methacrylate moieties. This film was then used as the surface for RAFT polymerization process of methyl methacrylate (MMA), styrene (S), and tert-butyl acrylate (TBA) in the presence of a free RAFT agent and a free radical initiator, resulting in grafted polymer chains. The molecular weights and the polydispersity indices (PDI) of the sacrificial polymers were determined by gel permeation chromatography (GPC). The stages of surface modification were investigated using X-ray photoelectron spectroscopy (XPS), ellipsometry, and atomic force microscopy (AFM) to confirm the surface composition, thickness, and film morphology, respectively. UV-Vis spectroscopy also confirmed the formation of an electro-optically active crosslinked carbazole film with a π-π * absorption band from 450-650 nm. Static water contact angle measurements confirmed the changes in surface energy of the ultrathin films with each modification step. The controlled polymer growth from the conducting polymer-modified surface suggests the viability of combining electrodeposition and grafting-through approach to form functional polymer ultrathin films.

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“…Also, a non-significant increase in the coated tablet weight and thickness was detected between the mono coated formulas themselves (F1, F3, and F5) and also between the double coated formulas themselves (F2, F4, and F6) where different coating solution T1, T2 and T3 used. This was attributed to the slight increase in the viscosity of the enteric coating formulas resulting from increasing eudragit L-100 concentration from 13.5% in (F1, F2) to 15.5% and 17.5% in (F3, F4) and (F5, F6) respectively, an effect which might increase the hydrodynamic drag during the dipping process [22][23][24]. Furthermore, non-significant differences were observed in the hardness between the core and coated tablets and between the coated tablets themselves indicating that the enteric oroslippery coating formula had a negligible effect on the hardness.…”

Section: Resultsmentioning

confidence: 99%

Application of the New Oroslippery Technology in the Preparation of Enteric Slippery Coated Tablet of Naproxen

Maraie

Alhamdany

2017

Int J Pharm Pharm Sci

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Objective: The aim of this study was to formulate enteric coated oroslippery tablets (OSTs) of naproxen to overcome the common problems of stomach irritation and swallowing difficulties which accompanied the administration of naproxen tablets.Methods: Different formulas of enteric slippery tablets were prepared by direct compression method. Various parameters were investigated like the effect of eudragit L-100 (eud.) concentration (as an enteric polymer), coating level and effect of different concentrations of croscarmellose sodium CCS (as super disintegrant) on the physical properties. Finally, in an in vitro disintegration and release study was carried out. Results:The enteric slippery optimal formula (F8) was selected to consist of double coat (17.5% eudragit (eud.)) with core tablet containing (6% CCS). It was found that this optimal formula having an acceptable physical property (friability, hardness, thickness and weight variation). Besides, the best acid resistant potential represented by the protection of the OSTs for 2 h in 0.1 N HCl without any sign of disintegration and drug release. Moreover, it was found that (F8) has a disintegration time equal to (8±1.36 min) and release of 80% (20±0.18 min) in phosphate buffer pH 6.8. Conclusion:The result revealed the successful preparation of naproxen tablets using enteric slippery coating that can be easily swallowed and prevent direct irritation of the stomach with acceptable tablet weight.

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Spin and dip coating of light-emitting polymer solutions: Matching experiment with modelling

Cited by 150 publications

References 34 publications

New Easily Swallowed Tablets with Slippery Coating for the Antihypertensive Drug Valsartan

New Easily Swallowed Tablets with Slippery Coating for the Antihypertensive Drug Valsartan

RAFT “grafting-through” approach to surface-anchored polymers: Electrodeposition of an electroactive methacrylate monomer

Application of the New Oroslippery Technology in the Preparation of Enteric Slippery Coated Tablet of Naproxen

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