Spin-orbit coupling is key to all-electrical control of quantum-dot spin qubits, and is frequently stronger for holes than for electrons. Here we investigate Pauli spin blockade for two heavy holes in a gated double quantum dot in an in-plane magnetic field. The interplay of the complex Zeeman and spin-orbit couplings causes a blockade leakage current anisotropic in the field direction. The period of the anisotropic leakage is critically dependent on the relative magnitude of Zeeman interaction terms linear and cubic in the magnetic field. The current and singlet-triplet exchange splitting can be effectively adjusted by an appropriate choice of field direction, providing a simple control variable for quantum information processing and a way of tailoring magnetic interactions in hole spin qubits.Spin-based quantum information processing platforms relying on hole quantum dots (QDs) have recently attracted considerable attention [1][2][3][4][5][6][7][8][9][10][11], since they permit long spin coherence and electrically driven spin resonance thanks to the strong hole spinorbit (SO) interaction [12][13][14][15][16][17][18][19][20]. Owing to their effective spin J = 3 2 , spin dynamics in hole systems often exhibits physics not found in electron systems [21][22][23][24][25][26]. Experimental progress in realizing high-quality two-dimensional (2D) and even lower-dimensional hole systems has opened the door to hole-based computing architectures [27][28][29][30]. Probing the strengths of SO coupling and hole-hole interactions is thus highly relevant for quantum computing. Pauli spin blockade [31,32], the blocking of charge transport through QDs due to the Pauli exclusion principle, may be employed to perform this task in InSb, Si, Ge-Si core-shell wires, and GaAs [7,8,11,33].Pauli spin blockade (PSB) is lifted by spin-flip processes most commonly originating in the SO or hyperfine interactions. Electron PSBs at low magnetic fields are primarily lifted by the hyperfine coupling to the nuclei [34][35][36], unless the singlet-triplet splitting is large due to a sizable interdot tunnel coupling [37][38][39]. Electron SO interaction only becomes a major lifting mechanism at stronger magnetic fields and strong interdot tunneling [38]. For hole QDs, in contrast, the strong SO interaction is expected to be the dominant blockade lifting mechanism [7,8,11,33] even at low magnetic fields, particularly due to the suppression of hole contact hyperfine interaction. Spin-flip cotunneling processes may also give rise to a leakage current [11].Here we investigate PSB in a gate-defined hole double QD in an in-plane magnetic field. We derive an effective SO tunneling Hamiltonian between (1, 1) and (0, 2), with (N L , N R ) charge state on the left and right dot. Our work shows that the PSB is anisotropic in the field orientation and strongly influenced by the complex Zeeman interaction, which in hole QDs may have terms both linear and cubic in the field strength. We find that the period of the anisotropic leakage is determined by the domin...