A quantum particle propagates subdiffusively on a strongly disordered chain when it is coupled to itinerant hard-core bosons. We establish a generalized Einstein relation (GER) that relates such subdiffusive spread to an unusual time-dependent drift velocity, which appears as a consequence of a constant electric field. We show that GER remains valid much beyond the regime of the linear response. Qualitatively, it holds true up to strongest drivings when the nonlinear field-effects lead to the Stark-like localization. Numerical calculations based on full quantum evolution are substantiated by much simpler rate equations for the boson-assisted transitions between localized Anderson states.Introduction-Over two decades after the outstanding discovery of the Anderson localization (AL) phenomena [1], the effect of the interplay between the disorder and many-body interactions on transport properties of metals started to be recognized as one of the fundamental unsolved problems in solid state physics [2,3]. The importance of interactions on AL systems is now identified as a concept of the many-body localization (MBL) [4,5]. The presence of MBL has been theoretically confirmed predominantly in systems that posses only spin or charge degrees of freedom [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Moreover, the existence of MBL has been found in a few experimental studies [23-28]. Among several characteristic features of strongly disordered systems is unusually slow time evolution of characteristic physical properties [27,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]] that typically emerges as subdiffusive dynamics as a precursor to MBL transition [18,39,[49][50][51][52][53][54].In this Letter we consider the effect of driving (via the constant electric field) on a quantum particle in a random chain coupled to itinerant hard-core bosons (HCB). We note that such a system simulates the propagation of a (single) charge coupled to spin degrees in strongly correlated systems, as e.g., the disordered Hubbard typemodels [44,55,56], being realized in cold-atom experiments [23][24][25][26][27][28]. It has long been assumed that the AL phenomenon is destroyed by the electron-phonon coupling via the mechanism of phonon-assisted hopping [57,58]. Recently the absence of localization and the onset of normal diffusion of a particle coupled to standard itinerant bosons has been confirmed via a direct quantum evolution [59]. Still, the itinerant HCB appear to be a separate case with a transient or even persistent subdiffusive dynamics [54,60]. While the subdiffusive dynamics has been found in various disordered interacting systems, the behavior of such system under constant driving remains predominantly unexplored [61] whereby in driven MBL systems the focus has been mostly on periodic drivings [9,[62][63][64][65].Transport properties of disordered quantum interacting many-body systems depend on the disorder strength. Weakly disordered systems typically display generic