Spinal Anaesthesia with Hyperbaric Prilocaine in Day-Case Perianal Surgery: Randomised Controlled Trial

Kaban, Ozden Gorgoz; Yazicioglu, Dilek; Akkaya, Taylan; Sayın, Murat; Seker, Duray; Gümüş, Haluk

doi:10.1155/2014/608372

Cited by 19 publications

(18 citation statements)

References 29 publications

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“…In day-case perianal surgery, Kaban compared 30 mg 2% hyperbaric prilocaine with fentanyl 20 μg versus 7.5 mg of 0.5% hyperbaric bupivacaine with fentanyl 20 μg 29. Time to unassisted ambulation, time to sensory block resolution, and time to home discharge were significantly shorter in the prilocaine group than in the bupivacaine group.…”

Section: Resultsmentioning

confidence: 99%

“…In 25 day-case perianal surgeries, Kaban showed one case of POUR after intrathecal 30 mg of 2% hyperbaric prilocaine with fentanyl 20 μg 29. Using 40 or 50 mg 2% hyperbaric prilocaine, mean time to first micturition ranged from 195 to 249 min with no cases of POUR in 160 patients 22,26,31…”

Section: Resultsmentioning

confidence: 99%

“…Compared to an equipotent dose of long-acting spinal anesthetic, prilocaine showed a more rapid recovery and return of bladder function, associated with lower incidence of POUR (Evidence Ib) 23,29,36. Future trials are advocated to establish possible differences between prilocaine over other local anesthetics with similar favorable and safety profile, such as articaina and chloroprocaine.…”

Section: Resultsmentioning

confidence: 99%

“…Although the combination of prilocaine and fentanyl (20–25 μg) has been tested with the aim to improve the quality and extend the duration of the spinal block, pruritus and urinary retention are possible side effects which can delay home discharge 29,36,37…”

Section: Resultsmentioning

confidence: 99%

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Prilocaine hydrochloride 2% hyperbaric solution for intrathecal injection: a clinical review

Manassero¹,

Fanelli²

2017

LRA

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Prilocaine is a local anesthetic characterized by intermediate potency and duration and fast onset of action. As hyperbaric formulation of 5% solution, it was introduced and has been successfully used for spinal anesthesia since 1960. A new formulation of 2% plain and hyperbaric solution is currently available in Europe. Because of its lower incidence of transient neurological symptoms, prilocaine is suggested as substitute to lidocaine and mepivacaine in spinal anesthesia for ambulatory surgery, as well as a suitable alternative to low doses of long-acting local anesthetics. The National Library of Medicine database, the Excerpta Medica database, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials database, were searched for the period 1970 to September 2016, with the aim to identify studies evaluating the intrathecal use of 2% prilocaine. A total of 13 randomized clinical trials (RCTs), 1 observational study, 2 dose finding, and 4 systematic reviews has been used for this review. The studies evaluated showed that 2% hyperbaric prilocaine due to a favorable anesthetic and safety profile is an alternative drug to lidocaine and mepivacaine for spinal anesthesia of intermediate or short duration. In comparison with plain solutions, hyperbaricity remarkably accelerates the onset and offset times of intrathecal 2% prilocaine. Literature suggests a dose ranging between 40 and 60 mg of prilocaine for lower extremities and lower abdominal procedures lasting up to 90 min, whereas a dose ranging from 10 to 30 mg is appropriate for perineal surgery. Readiness for discharge occurs in ~4 h from spinal administration.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Prilocaine hydrochloride 2% hyperbaric solution for intrathecal injection: a clinical review

Manassero¹,

Fanelli²

2017

LRA

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“…Prilocaine is a short to intermediate-acting amino amide with lower central nervous system toxicity and a rapid degradation time. Recently, this drug has been used in spinal anaesthesia for short and medium-length operations in place of lidocaine due to less transient neurological symptoms, with particular emphasis on outpatient surgery (Kaban et al, 2014;Manassero and Fanelli, 2017).…”

Section: Introductionmentioning

confidence: 99%

Fast-Track Surgery and Early Rehabilitation for Total Hip Replacement in Hospital of Traumatology and Orthopaedics

Birznieks

Golubovska

Repša³

et al. 2019

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Due to an ageing population, the necessity for hip replacement has grown, and therefore, new options are being sought, such as the Fast-track principle, to improve patient condition, reduce their hospital stay and enhance the hospital’s ability to treat more patients. The aim of this study was to investigate the effects of same-day patient mobilisation on pain, side effects, complications, duration of hospital stay, and recovery after primary hip replacement, using intermediate-acting local anaesthetics in spinal anaesthesia (SA). A prospective, randomised study was conducted at the Hospital of Traumatology and Orthopaedics. Forty-six patients undergoing total hip replacement were selected and divided into two groups. Spinal anaesthesia was performed in study group (P) with 70 mg plain prilocaine. The control group (B) received 18 mg heavy bupivacaine in SA. On the first postoperative day, pain during movement was 2.00 (P) and 3.33 (B) on the Numeric Pain Rating Scale, the duration of hospital stay in the study group was shorter by ~1 day, and patient self-care was better in the study group. When the Fast-track principle is used with intermediate-acting SA and early rehabilitation, it is possible to reduce post-operative pain during movement, reduce the length of stay and improve patient self-care abilities.

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Quantification of systemic o-toluidine after intrathecal administration of hyperbaric prilocaine in humans: a prospective cohort study

et al. 2021

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Spinal Anaesthesia with Hyperbaric Prilocaine in Day-Case Perianal Surgery: Randomised Controlled Trial

Cited by 19 publications

References 29 publications

Prilocaine hydrochloride 2% hyperbaric solution for intrathecal injection: a clinical review

Prilocaine hydrochloride 2% hyperbaric solution for intrathecal injection: a clinical review

Fast-Track Surgery and Early Rehabilitation for Total Hip Replacement in Hospital of Traumatology and Orthopaedics

Quantification of systemic o-toluidine after intrathecal administration of hyperbaric prilocaine in humans: a prospective cohort study

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