Spinal Ankylosis in Old Rhesus Monkeys

Sokoloff, Louis; Snell, Katie; Stewart, H. L.

doi:10.1097/00003086-196800610-00032

Cited by 14 publications

(9 citation statements)

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“…Sokoloff et a1 (18) described vertebral osteophytosis in an elderly rhesus monkey (Mucuca mulata). The animal lesions were restricted to the thoracolumbar spine and consisted of an osteophyte protruding from the right anterolateral aspect of the tenth thoracic vertebra which merged distally into the ossified longitudinal ligament of the adjacent 4 vertebral bodies.…”

Section: A On Kodak Electron Image Glass Plates (2)mentioning

confidence: 99%

Calcium Pyrophosphate Dihydrate Crystal Deposition Disease with Concurrent Vertebral Hyperostosis in a Barbary Ape

Kandel¹,

Renlund²,

Pt³

et al. 1983

Arthritis & Rheumatism

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Calcium pyrophosphate dihydrate crystal deposition in joint diseases is a we!! recognized common arthropathy associated with acute arthritis (pseudogout) as well as chronic joint disease (1). The etiology of this disorder is obscure, and an adequate animal model has yet to be found. We describe an elderly Barbary ape (Macaca sylvanus) that had calcium pyrophosphate dihydrate crystals deposited in a tissue distribution similar to that observed in humans. Crystal deposits were seen in intervertebral discs, menisci, articular cartilage, and ligament insertions. These were associated in some sites with degenerative changes of cartilage and bone. Concomitantly, the ape had skeletal hyperostosis affecting the vertebral bodies and bony excrescences at the site of ligament and tendon attachment to bone.Case report. A 20-year-old female Barbary ape (Macaca sylvanus) on exhibit at the Metropolitan Toronto Zoo but originally from the National Zoo in Washington, DC was examined because of increasing lameness. Radiographic examination showed diffuse ligamentous calcification along the anterolateral aspect of the vertebra! bodies which was most marked in the lumbar region. Localized osteophytosis of cervical, thoracic, and lumbar vertebra! bodies was also seen. Hip, knee, and elbow joints showed degenerative changes characterized by narrowing of the joint space, subchondral sclerosis, and marginal osteophyte formation. There was calcification of tendon insertions at the ankle and elbow. Because of increasing disability and repeated attacks by others in her group, she was killed. Postmortem examination was performed at the Metropolitan Toronto Zoo, and the carcass was forwarded to Mount Sinai Hospital for further investigation of the skeletal lesions.Antemortem blood analysis was within normal limits, except for alkaline phosphatase which was markedly elevated at 217 IU (normal 0-95 IU). The serum calcium was 9.9 mg/dl (normal 8.8-103, phosphorus was 3.9 mgldl (normal 2.74.2), and albumin was 3.4 gmldl.Materials and methods. The skeletal tissues were examined and fixed in acetate buffered formalin. The lumbar spine and knee joints were cut sagitally at 1.0-cm intervals and x-rayed in a Faxitron, Mode! 8050-010, self-contained x-ray unit. Representative sections of the soft tissue and cartilage were removed, and the bone specimens then were decalcified in RDO, solution and double-embedded in celloidin-paraffin. Five-micron thick unstained sections and sections stained with hematoxylin and eosin and toluidine blue were prepared for light microscopic examination. A

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Section: A On Kodak Electron Image Glass Plates (2)mentioning

confidence: 99%

Calcium Pyrophosphate Dihydrate Crystal Deposition Disease with Concurrent Vertebral Hyperostosis in a Barbary Ape

Kandel¹,

Renlund²,

Pt³

et al. 1983

Arthritis & Rheumatism

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“…Spinal hyperostosis similar to DISH has been described in Dinosaurs, a Saber-toothed cat, and old Rhesus monkeys (Sokoloff et al 1968;Bjorkengren et al 1987;Rothschild 1987). Only two case reports of DISH in dogs have been published (Woodard et al 1985;Morgan & Stavenborn 1991), and no studies describing DISH in cats have been published.…”

Section: Introduction and Etiologymentioning

confidence: 99%

Spinal hyperostosis in humans and companion animals

Kranenburg

Hazewinkel

Meij

2013

Veterinary Quarterly

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Both spondylosis and diffuse idiopathic skeletal hyperostosis (DISH) are prevalent in humans and are considered distinct entities. Nowadays, the term spondylosis is in the biomedical literature mostly used when also degenerative disc disease is present. In companion animals, many reports on spondylosis, often without intervertebral disc degeneration, are described. The nomenclature and the definitions of both spondylosis and DISH in the biomedical and veterinary literature should be more in line to facilitate comparison. DISH occurs in dogs but has not been described in cats yet. DISH and spondylosis can co-occur in dogs in one animal. Boxers may serve as translational disease models for the elucidation of the gene(s) involved in the (etio)pathogenesis of DISH or serve as a test population for newly developed treatment options.

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“…The Nomina Anatómica |NA, 1983] lists annulus as the preferred spelling with anulus as an officially recognized alternative. These terminologies are issued by committees and are listed alphabetically under 'Interna tional '. semblance to the human in pathoanatomy of the monk ey spine [Sokoloff et al, 1968]. For example, degenera tion and loss of the NP affect rhesus monkeys and espe cially thoracic segments of the male (Macaca mulatto).…”

Section: Introductionmentioning

confidence: 99%

Comparative Development of Thoracic Intervertebral Discs and Intra-Articular Ligaments in the Human, Monkey, Mouse, and Cat

Lohse¹,

Hyde²,

Benson

1985

Cells Tissues Organs

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Developmental features of thoracic intervertrebral discs and their association in the adult with other vertebral structures were investigated in four species. The human anulus fibrosus, nucleus pulposus, and intra-articular ligaments were compared to those of the fetal rhesus monkey, mouse, and kitten. Photomicrographs of transverse sections of intervertebral discs document the presence of intra-articular ligaments in fetuses of these four species. Both transverse and sagittal sections of kittens were used to identify the intercapital ligament as it differentiated from the dorsal part of the intra-articular ligament. Relatively frequent dorsal herniation of the thoracic nucleus pulposus in humans may be due to the vestigial nature of the human intra-articular ligament. Quadrupeds have well-developed intra-articular ligaments, which explains anatomically the paucity of dorsal protrusions of the nucleus pulposus into the vertebral canal in the thoracic region of the cat and mouse when compared to the human. The intra-articular ligament was closely associated with the developing prenatal mammalian intervertebral disc in the four species studied, and this relationship and its surgical importance are described.

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Spinal Ankylosis in Old Rhesus Monkeys

Cited by 14 publications

References 0 publications

Calcium Pyrophosphate Dihydrate Crystal Deposition Disease with Concurrent Vertebral Hyperostosis in a Barbary Ape

Calcium Pyrophosphate Dihydrate Crystal Deposition Disease with Concurrent Vertebral Hyperostosis in a Barbary Ape

Spinal hyperostosis in humans and companion animals

Comparative Development of Thoracic Intervertebral Discs and Intra-Articular Ligaments in the Human, Monkey, Mouse, and Cat

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