“…It has already been shown that the action of oxaliplatin occurs only in myelinated fibers, since oxaliplatin induced bursts of action potentials in myelinated A-fibers, but not in unmyelinated C-fibers (Sittl et al, 2010). Additionally, recent studies have shown that oxaliplatin can affect the expression levels of GJs in astrocytes (Yoon et al, 2013) and dorsal root ganglia (DRG) satellite glial cells (Warwick and Hanani, 2013), while GJ blockage by carbenoxolone results in analgesic-like effects (Rouach et al, 2003;Vessey et al, 2004). Furthermore, GJ hemichannel blockade was found to be neuroprotective in some cases of global cerebral ischemia in nearterm fetal sheep (Davidson et al, 2014), while gap junctional communication could counteract the effects of the anti-tumor agent cisplatin (homologous to oxaliplatin) (Broomand et al, 2009).…”