Spinal clear cell meningioma without dural attachment: a case report and literature review

Maamri, Kais; Taieb, Mohamed Amine Hadj; Trifa, Amine; Elkahla, Ghassen; Njima, Manel; Darmoul, Mehdi

doi:10.1016/j.radcr.2022.02.052

Cited by 4 publications

(5 citation statements)

References 30 publications

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“…Histologically, our case study tumor showed sheeting architecture containing round to polygonal cells with clear cytoplasm and many small clumps of collagen fibers. Whorl formation and psammoma bodies were poorly formed and consistent with previous reports of spinal CCM [ 7 , 8 ]. However, it is noteworthy that immunohistochemically, nuclear loss of the SMARCE1 expression in the tumor cells was confirmed in our case.…”

Section: Discussionsupporting

confidence: 91%

“…Maamri et al . reported that some spinal CCMs do not show dural attachment [ 8 ]; non-adherent CCMs are very rare, as only 20 cases have been reported in the English literature. In those cases, no metastases were reported.…”

Section: Discussionmentioning

confidence: 99%

“…Intraspinal CCMs are very rare, and less than 100 cases have been reported in the English literature [ 7 ]. CCMs without dural adhesions are even rarer, with only 20 cases reported [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Lumbar clear cell meningioma mimicking schwannoma 7 years after resection of the same type of intracranial tumor: a case report

Horikawa,

Nozawa,

Suzui

et al. 2024

J Med Case Reports

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Background Meningioma is the second most common intradural extramedullary tumor, following schwannoma. Meningioma is primarily categorized as benign World Health Organization grade 1, but clear cell meningioma is grade 2 of the intermediate malignant category. Clear cell meningiomas are rare, accounting for less than 1% of all meningioma tumors. There is no previous report of multiple intraspinal clear cell meningiomas without dural attachment. Case presentation A 27-year-old Asian male patient presented with lower right extremity pain, and had undergone tumor resection for intracranial clear cell meningioma 7 years previously, with re-resection and radiotherapy for local tumor recurrence at our hospital’s department of neurosurgery being carried out 4 years previously. No recurrence was observed since then. Preoperative lumbar magnetic resonance imaging showed two tumors at the L1 and L4 levels, both mimicking schwannoma with well-defined margins, no dural tail sign and homogeneous internal contrast. Intraoperative findings on tumor resection showed two tumors contiguous with the right L2 and L5 roots, which were not attached to the dura mater, similar to a schwannoma. After gross total resection, the postoperative pathology revealed no nuclear SMARCE1 antibody staining. The patient was diagnosed with clear cell meningioma. The patient’s postoperative course went well, with no symptoms of nerve dropout and no recurrence 2 years after surgery. In this case, both lumbar lesions were well demarcated and spherical in shape, occurring with single roots. Tumor characteristics suggested a primary rather than a metastatic lesion. Clear cell meningioma is characterized by a SMARCE1 mutation and is different from other types of meningiomas. Conclusion To the best of our knowledge, this is the first report of multiple intraspinal clear cell meningiomas without dural attachment at the lumbar spine after resection of intracranial clear cell meningioma. We speculate that the two tumors were de novo lesions on the basis of the features of the tumors, although they were detected 7 years after the resection of intracranial clear cell meningioma.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Lumbar clear cell meningioma mimicking schwannoma 7 years after resection of the same type of intracranial tumor: a case report

Horikawa,

Nozawa,

Suzui

et al. 2024

J Med Case Reports

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“…The results of this literature review are shown in ►Tables 1-1-30 and 2. [31][32][33][34][35][36][37]…”

Section: Literature Search Strategymentioning

confidence: 99%

“…The results of this literature review are shown in Tables 1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 and 2 . 31 32 33 34 35 36 37 …”

Section: Case Descriptionmentioning

confidence: 99%

Pituitary Adenoma Coexistent with Sellar Clear Cell Meningioma Unattached to the Dura: Case Report and Treatment Considerations

Chatain,

Chee,

Driscoll

et al. 2024

J Neurol Surg Rep

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Collision tumors involving the sella are rare. Intrasellar collision tumors are most commonly composed of a combination of pituitary adenomas and pituitary neuroendocrine tumors; however, collision tumors consisting of a pituitary adenoma and intrasellar meningioma are exceedingly rare. The authors present the case of a 47-year-old man who presented with progressive right eye vision loss. Magnetic resonance imaging showed a large, heterogeneously enhancing sellar mass with suprasellar extension. Using a transcranial approach with a right subfrontal craniotomy, near-total resection of the mass was achieved. Histologic analysis confirmed a diagnosis of a gonadotroph adenoma with concomitant clear cell meningioma (CCM). This patient was discharged with improvement in visual acuity and no signs of diabetes insipidus. Given the indistinguishable radiographic characteristics of pituitary adenoma and CCM, a preoperative diagnosis of a collision tumor was difficult. This case was uniquely challenging since the CCM component lacked the classic dural attachment that is associated with meningiomas on neuroimaging. CCMs are classified as central nervous system (CNS) World Health Organization (WHO) grade 2 tumors and tend to behave more aggressively, therefore warranting close surveillance for signs of tumor recurrence. This is the first case to report a collision tumor consisting of pituitary adenoma and CCM.

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Intradural Lumbosacral Tumors

Akhaddar

2023

Atlas of Sciatica

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Spinal clear cell meningioma without dural attachment: a case report and literature review

Cited by 4 publications

References 30 publications

Lumbar clear cell meningioma mimicking schwannoma 7 years after resection of the same type of intracranial tumor: a case report

Lumbar clear cell meningioma mimicking schwannoma 7 years after resection of the same type of intracranial tumor: a case report

Pituitary Adenoma Coexistent with Sellar Clear Cell Meningioma Unattached to the Dura: Case Report and Treatment Considerations

Intradural Lumbosacral Tumors

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