Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with <i>Phaseolus vulgaris</i> leucoagglutinin

Slugg, Robert M.; Light, Alan R.

doi:10.1002/cne.903390106

Cited by 141 publications

(138 citation statements)

References 44 publications

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“…Nociceptive afferents that terminate in lPB and KF are known to ascend to dl-pons along the vsc (Slugg and Light, 1994;Bourgeais et al, 2003). In the present study, we found that many type II dendrites extended laterally into vsc, in which the distal dendritic processes also exhibited considerably higher number of varicosities.…”

Section: Pneumotaxic Neurons Integrate Pain And/or Musculoskeletal Insupporting

confidence: 61%

“…The somata and/or dendritic domains of some pneumotaxic neurons we identified were located in the lPB and KF nuclei, which are the terminating fields of some nociceptive afferents (Slugg and Light, 1994;Bourgeais et al, 2003). Recently, it was reported that certain respiratory rhythmic neurons in KF responded to cutaneous noxious stimuli and that the resulting respiratory enhancement was attenuated by bilateral inhibition of the parabrachial complex (Jiang et al, 2004).…”

Section: Pneumotaxic Neurons Integrate Pain And/or Musculoskeletal Inmentioning

confidence: 98%

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Cytoarchitecture of Pneumotaxic Integration of Respiratory and Nonrespiratory Information in the Rat

Song¹,

Yu²,

Poon³

2006

J. Neurosci.

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The "pneumotaxic center" in the Kölliker-Fuse and medial parabrachial nuclei of dorsolateral pons (dl-pons) plays an important role in respiratory phase switching, modulation of respiratory reflex, and rhythmogenesis. Recent electrophysiological and neural tracing data implicate additional pneumotaxic nuclei in (and a broader role for) the dl-pons in integrating respiratory and nonrespiratory information. Here, we examined the cytoarchitecture of the greater pneumotaxic center and its integrating function by using combined extracellular recording and juxtacellular labeling of unit respiratory rhythmic neurons in dl-pons in urethane-anesthetized, vagotomized, paralyzed, and servo-ventilated adult Sprague Dawley rats. Perievent histogram analysis identified four major types of neuronal discharge patterns: inspiratory, expiratory (with three subdivisions), inspiratory-expiratory, and expiratory-inspiratory phase spanning, sometimes with mild tonic background activity. Most recorded neurons were localized in the Kölliker-Fuse and medial parabrachial nuclei, but some were also found in lateral parabrachial nucleus, intertrigeminal nucleus, principal trigeminal sensory nucleus, and supratrigeminal nucleus. The majority of labeled neurons had large and spatially extended dendritic trees that spanned several of these dl-pons subnuclei, often with terminal dendrites ending in the ventral spinocerebellar tract. The distal sections of the primary and higher-order dendrites exhibited rich varicosities, sometimes with dendritic spines. Axons of some labeled neurons were traced all the way to the ventrolateral pons (vl-pons). These findings extend and generalize the classical definition of the pneumotaxic center to include extensive somaticaxonal-dendritic integration of complex descending and ascending respiratory information as well as nociceptive and possibly musculoskeletal and trigeminal information in multiple dl-pons and vl-pons structures in the rat.

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Section: Pneumotaxic Neurons Integrate Pain And/or Musculoskeletal Insupporting

confidence: 61%

Section: Pneumotaxic Neurons Integrate Pain And/or Musculoskeletal Inmentioning

confidence: 98%

Cytoarchitecture of Pneumotaxic Integration of Respiratory and Nonrespiratory Information in the Rat

Song¹,

Yu²,

Poon³

2006

J. Neurosci.

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“…Electrophysiological investigations and correlated anatomical data have also provided evidence that VBSNC neurons, including nociceptive neurons in subnuclei caudalis and interpolaris, contribute to VBSNC projections to the other regions noted above that are involved in pain, including its reflex expression or its modulation. These include direct projections from the nociceptive neurons to peri-aqueductal gray and the parabrachial area (from where there are projections to amygdala and hypothalamus) as well as projections to other components of the ipsilateral VBSNC, the V motor nucleus and contralateral VBSNC (lacquin et al, 1990;Hayashi, 1992;Slugg and Light, 1994;Bester et al, 1995;Jasmin et al, 1997;Meng et al, 1997;Allen and Pronych, 1997;and see Dubner and Bennett, 1983;Dubner, 1985;Sessle, 1987;Craig and Dostrovsky, 1997 As noted above, studies in either anesthetized or unanesthetized animals have documented neuronal responses to cutaneous nociceptive afferent inputs that have provided strong evidence that both NS and WDR neurons exist within the VBSNC, particularly in the subnucleus caudalis, and that they are critical brainstem elements for the detection and discrimination of superficial pain in the craniofacial region. Can a similar conclusion be applied to other forms of craniofacial nociceptive inputs?…”

Section: Other Evidencementioning

confidence: 99%

Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates

Sessle

2000

Critical Reviews in Oral Biology & Medicine

614

541

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This paper reviews the recent advances in knowledge of brainstem mechanisms related to craniofacial pain. It also draws attention to their clinical implications, and concludes with a brief overview and suggestions for future research directions. It first describes the general organizational features of the trigeminal brainstem sensory nuclear complex (VBSNC), including its input and output properties and intrinsic characteristics that are commensurate with its strategic role as the major brainstem relay of many types of somatosensory information derived from the face and mouth. The VBSNC plays a crucial role in craniofacial nociceptive transmission, as evidenced by clinical, behavioral, morphological, and electrophysiological data that have been especially derived from studies of the relay of cutaneous nociceptive afferent inputs through the subnucleus caudalis of the VBSNC. The recent literature, however, indicates that some fundamental differences exist in the processing of cutaneous vs. other craniofacial nociceptive inputs to the VBSNC, and that rostral components of the VBSNC may also play important roles in some of these processes. Modulatory mechanisms are also highlighted, including the neurochemical substrate by which nociceptive transmission in the VBSNC can be modulated. In addition, the long-term consequences of peripheral injury and inflammation and, in particular, the neuroplastic changes that can be induced in the VBSNC are emphasized in view of the likely role that central sensitization, as well as peripheral sensitization, can play in acute and chronic pain. The recent findings also provide new insights into craniofacial pain behavior and are particularly relevant to many approaches currently in use for the management of pain and to the development of new diagnostic and therapeutic procedures aimed at manipulating peripheral inputs and central processes underlying nociceptive transmission and its control within the VBSNC.

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“…The lateral part of the pPB receives nociceptive information from where it is conveyed to other brain areas including the extended amygdala [40,41]. The pPB is divided into a number of subregions that project to different parts of the amygdala.…”

Section: Spinopontoamygdaloid Pathwaymentioning

confidence: 99%

Emotional regulation of pain: the role of noradrenaline in the amygdala

Strobel

Hunt

Sullivan

et al. 2014

Sci. China Life Sci.

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The perception of pain involves the activation of the spinal pathway as well as the supra-spinal pathway, which targets brain regions involved in affective and cognitive processes. Pain and emotions have the capacity to influence each other reciprocally; negative emotions, such as depression and anxiety, increase the risk for chronic pain, which may lead to anxiety and depression. The amygdala is a key-player in the expression of emotions, receives direct nociceptive information from the parabrachial nucleus, and is densely innervated by noradrenergic brain centers. In recent years, the amygdala has attracted increasing interest for its role in pain perception and modulation. In this review, we will give a short overview of structures involved in the pain pathway, zoom in to afferent and efferent connections to and from the amygdala, with emphasis on the direct parabrachio-amygdaloid pathway and discuss the evidence for amygdala's role in pain processing and modulation. In addition to the involvement of the amygdala in negative emotions during the perception of pain, this brain structure is also a target site for many neuromodulators to regulate the perception of pain. We will end this article with a short review on the effects of noradrenaline and its role in hypoalgesia and analgesia. pain, learning, stress, parabrachial Citation:Strobel C, Hunt S, Sullivan R, Sun JY, Sah P. Emotional regulation of pain: the role of noradrenaline in the amygdala.

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Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin

Cited by 141 publications

References 44 publications

Cytoarchitecture of Pneumotaxic Integration of Respiratory and Nonrespiratory Information in the Rat

Cytoarchitecture of Pneumotaxic Integration of Respiratory and Nonrespiratory Information in the Rat

Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates

Emotional regulation of pain: the role of noradrenaline in the amygdala

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