Spinal cord injury effectively ameliorated by neuroprotective effects of rosmarinic acid

Shang, Aijia; Yang, Ying; Wang, Hangyan; Tao, Benzhang; Wang, Jing; Wang, Zhongfeng; Zhou, Ding-biao

doi:10.1080/1028415x.2015.1103460

Cited by 38 publications

(20 citation statements)

References 31 publications

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“…RosA inhibited neuronal apoptosis through targeting ROS and inflammatory responses in SCI. (Shang et al, 2017) Experimental diabetes with cerebral ischemia…”

Section: Effect Of Rosmarinic Acid On Other Inflammatory Diseasesmentioning

confidence: 99%

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

et al. 2020

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Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the antiinflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4dihydroxyphenyl lactic acid. It is discovered in many plants, like those of the Boraginaceae and Lamiaceae families. RosA has a wide range of pharmacological effects, including antioxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. The antiinflammatory effects of RosA have been revealed through in vitro and in vivo studies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. This article mainly describes the preclinical research of RosA on inflammatory diseases and depicts a small amount of clinical research data. The purpose of this review is to discuss the antiinflammatory effects of RosA in inflammatory diseases and its underlying mechanism.

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“…RosA inhibited neuronal apoptosis through targeting ROS and inflammatory responses in SCI. (Shang et al, 2017) Experimental diabetes with cerebral ischemia…”

Section: Effect Of Rosmarinic Acid On Other Inflammatory Diseasesmentioning

confidence: 99%

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

et al. 2020

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“…These plants may also enhance cognitive abilities and improve psychiatric and behavioral symptoms of dementia (Akhondzadeh et al, 2003;Perry, Bollen, Perry, & Ballard, 2003). Findings have also shown that the use of medicinal plants for the treatment of VaD and other neurodegenerative disease such as Parkinson may be beneficial because some of them, due to antioxidant properties, prevent neuronal loss and neurodegeneration (Kalaria et al, 2008;Shang et al, 2017;Sheu & Wu, 2017). It is also suggested that targeting the autophagylysosome pathway by using herbal products may be considered as a therapeutic option for Parkinson's disease (da Costa et al, 2017;Wang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Herbal medicine as a promising therapeutic approach for the management of vascular dementia: A systematic literature review

Ghorani‐Azam

Sepahi

Khodaverdi

et al. 2018

Phytotherapy Research

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Vascular dementia (VaD) generally refers to memory deficits and cognitive abnormalities that are resulted from vascular disease. In this study, we aimed to systematically review the literature wherein therapeutic effects of medicinal plants have been studied on VaD. A systematic literature search was performed in the PubMed, Scopus, Web of Science, Google Scholar, and other databases using VaD, and medicinal plants as key terms. No strict inclusion criteria were defined, and almost all clinical studies were included. A total of 524 articles were found, of which only 28 relevant articles with 3461 studied patients were included to this systematic review. The results showed that medicinal plants, particularly Sancaijiangtang and Ginkgo biloba could improve behavioral and psychological symptoms, working memory, Mini-Mental State Examination, and activities of daily living as well as neuropsychiatric features. It was also shown that the age, average progression of the disease, and the type of folk medicines effective in treating the disease are important factors in the management of VaD. The results of this review indicated that herbal therapy can be a potential candidate in the treatment of VaD; however, further studies are needed to confirm such efficiency.

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“…Various drugs exert antioxidative neuroprotective activities in the spinal cord by activating Nrf-2 such as asiatic acid, rosmarinic acid and resveratrol [ 12 25 26 27 ]. In Wistar rats, carnosol protects against SCI-induced oxidative stress and inflammation by modulating nuclear factor-κB, cyclooxygenase-2, and Nrf-2 levels [26].…”

Section: Discussionmentioning

confidence: 99%

Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1

Kim

Ahn

et al. 2017

Anat Cell Biol

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Glycogen synthase kinase (GSK)-3β and related enzymes are associated with various forms of neuroinflammation, including spinal cord injury (SCI). Our aim was to evaluate whether lithium, a non-selective inhibitor of GSK-3β, ameliorated SCI progression, and also to analyze whether lithium affected the expression levels of two representative GSK-3β–associated molecules, nuclear factor erythroid 2-related factor-2 (Nrf-2) and heme oxygenase-1 (HO-1) (a target gene of Nrf-2). Intraperitoneal lithium chloride (80 mg/kg/day for 3 days) significantly improved locomotor function at 8 days post-injury (DPI); this was maintained until 14 DPI (P<0.05). Western blotting showed significantly increased phosphorylation of GSK-3β (Ser9), Nrf-2, and the Nrf-2 target HO-1 in the spinal cords of lithium-treated animals. Fewer neuropathological changes (e.g., hemorrhage, inflammatory cell infiltration, and tissue loss) were observed in the spinal cords of the lithium-treated group compared with the vehicle-treated group. Microglial activation (evaluated by measuring the immunoreactivity of ionized calcium-binding protein-1) was also significantly reduced in the lithium-treated group. These findings suggest that GSK-3β becomes activated after SCI, and that a non-specific enzyme inhibitor, lithium, ameliorates rat SCI by increasing phosphorylation of GSK-3β and the associated molecules Nrf-2 and HO-1.

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Spinal cord injury effectively ameliorated by neuroprotective effects of rosmarinic acid

Abstract: The study demonstrates for the first time on the role of RA in protecting the spinal cord from injury and demonstrates its neuroprotection in wistar rats.

Cited by 38 publications

References 31 publications

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

Herbal medicine as a promising therapeutic approach for the management of vascular dementia: A systematic literature review

Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1

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