Spinal cord injury rehabilitation and mental health, SCReaM

Warner, Natasha; Ikkos, George; Gall, Angela

doi:10.1038/sc.2016.107

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…An interesting and encouraging aspect of the effectiveness of psychotherapeutic interventions is that they can also produce positive effects in SCI patients with pre-existing emotional disorders [59], which are generally considered as exclusion factors for rehabilitation and research procedures. The use of VR for mental disorder treatments started approximately 30 years ago [60], supporting the efficacy of VR interventions in individuals with depression and anxiety-related disorders, especially if used in combination with traditional psychotherapy [61].…”

Section: Vr As Therapy For Psychological Well-being and Independencementioning

confidence: 99%

Go Virtual to Get Real: Virtual Reality as a Resource for Spinal Cord Treatment

Leemhuis

Esposito

Gennaro

et al. 2021

IJERPH

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Increasingly, refined virtual reality (VR) techniques allow for the simultaneous and coherent stimulation of multiple sensory and motor domains. In some clinical interventions, such as those related to spinal cord injuries (SCIs), the impact of VR on people′s multisensory perception, movements, attitudes, and even modulations of socio-cognitive aspects of their behavior may influence every phase of their rehabilitation treatment, from the acute to chronic stages. This work describes the potential advantages of using first-person-perspective VR to treat SCIs and its implications for manipulating sensory-motor feedback to alter body signals. By situating a patient with SCI in a virtual environment, sensorial perceptions and motor intention can be enriched into a more coherent bodily experience that also promotes processes of neural regeneration and plasticity. In addition to the great potential of research, the most significant areas of interest concern is managing neuropathic pain, motor rehabilitation, and psychological well-being.

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Section: Vr As Therapy For Psychological Well-being and Independencementioning

confidence: 99%

Go Virtual to Get Real: Virtual Reality as a Resource for Spinal Cord Treatment

Leemhuis

Esposito

Gennaro

et al. 2021

IJERPH

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Section: Introductionmentioning

confidence: 99%

“…Various motor, sensory and sphincter abnormalities; aberrant muscle tone; and autonomic dysfunction may arise from spinal cord injury (SCI), which can be caused by direct or indirect external sources. 1 The risk of a series of paralysis‐related complications is significantly increased in patients with SCI, with severe and rapid bone density loss being the most pronounced manifestation. 2 , 3 The main reason for this phenomenon is the lack of mechanical stimulation, which leads to a decrease in the ability of osteoblasts to form and an increase in the bone resorption ability of osteoclasts.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR‐29b‐3p/DKK1 axis

Qin,

Liu

2024

J Cellular Molecular Medi

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Single immobilization theory cannot fully account for the extensive bone loss observed after spinal cord injury (SCI). Bone marrow mesenchymal stem cells (BMSCs) are crucial in bone homeostasis because they possess self‐renewal capabilities and various types of differentiation potential. This study aimed to explore the molecular mechanism of long non‐coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR‐29b‐2p expression using miR‐29b‐3p mimetics and inhibitors. Western blotting, real‐time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double‐luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR‐29b‐3p was downregulated. We identified the binding sites between miR‐29b‐3p and lncRNAs H19 and DKK1. H19 knockdown promoted BMSCs' osteogenic differentiation, whereas miR‐29b‐3p inhibition attenuated this effect. We discovered potential binding sites for miR‐29b‐3p in lncRNAs H19 and DKK1. Our findings suggest that long non‐coding RNA H19 mediates BMSCs' osteogenic differentiation in osteoporosis after SCI through the miR‐29b‐3p/DKK1 axis and by directly inhibiting the β‐catenin signalling pathway.

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