Spinal Cord MRI in Multiple Sclerosis

Muccilli, Alexandra; Seyman, Estelle; Oh, Jiwon

doi:10.1016/j.ncl.2017.08.009

Cited by 17 publications

(10 citation statements)

References 133 publications

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“…There is a fibrous tissue septum between the blood sinusoids. The blood flows slowly in it, mostly from the edge of the tumor to the center [ 19 ]. The nodules around the lesion are enhanced at an early stage and filled to the center of the lesion despite the prolonged time.…”

Section: Modeling and Simulation Resultsmentioning

confidence: 99%

Application of Dynamic Enhanced Magnetic Resonance Imaging in the Diagnosis of Hematological Malignancies

Shao

Xue-ping

Song

et al. 2021

Journal of Healthcare Engineering

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The use of dynamic enhanced magnetic resonance imaging technology can effectively explore the diagnosis and clinical application of hematological malignancies. This paper selected 60 patients with hematological malignancies from 2015 to 2019; all of whom were diagnosed with hematological malignancies, including 40 men and 20 women, aged between 40 and 77 years. The main clinical manifestations of the patient are hematological malignancies, fever, and other symptoms. We used Siemens 3.0T to perform MRI and dynamic enhanced MRI examinations on 30 patients with hematological tumors. The PACS system was used to collect and organize clinical data. All patients were pathologically confirmed and clinically diagnosed with hematological malignancies. Based on the clinical data of the patients, retrospective analysis and summary were conducted and the clinical manifestations of hematological malignancies were discussed. The results showed that the diagnostic accuracy of 30 cases of dynamic enhanced MRI was 100%, while the diagnostic accuracy of ordinary MRI was lower than that of dynamic enhanced MRI, P < 0.05 , and the difference was statistically significant. In addition, compared with dynamic enhanced MRI and MRI, P > 0.05 , the difference was not statistically significant. Therefore, the application of dynamic enhanced MRI in the diagnosis of hematological malignancies is valuable.

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Section: Modeling and Simulation Resultsmentioning

confidence: 99%

Application of Dynamic Enhanced Magnetic Resonance Imaging in the Diagnosis of Hematological Malignancies

Shao

Xue-ping

Song

et al. 2021

Journal of Healthcare Engineering

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“…Active lesions may be enhanced, although less frequently than brain lesions. Spinal cord atrophy can be seen occasionally in long course and progressive MS, especially in the upper segment (57). The similar disease of MS in peripheral organs is chronic inflammatory demyelination polyradiculoneuropathy (CIDP), which is a chronic multiphase disease involving peripheral nervous system (PNS).…”

Section: Summary Of Msmentioning

confidence: 99%

Clinical, Radiological and Pathological Characteristics Between Cerebral Small Vessel Disease and Multiple Sclerosis: A Review

Bijia

et al. 2022

Front. Neurol.

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Cerebral small vessel disease (CSVD) and multiple sclerosis (MS) are a group of diseases associated with small vessel lesions, the former often resulting from the vascular lesion itself, while the latter originating from demyelinating which can damage the cerebral small veins. Clinically, CSVD and MS do not have specific signs and symptoms, and it is often difficult to distinguish between the two from the aspects of the pathology and imaging. Therefore, failure to correctly identify and diagnose the two diseases will delay early intervention, which in turn will affect the long-term functional activity for patients and even increase their burden of life. This review has summarized recent studies regarding their similarities and difference of the clinical manifestations, pathological features and imaging changes in CSVD and MS, which could provide a reliable basis for the diagnosis and differentiation of the two diseases in the future.

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“…This pathological sensitivity is increased at higher field strengths where the increased signal-to-noise and contrast-to-noise allows for small and subtle lesions to be identified (Mainero et al, 2009;Dula et al, 2016;Kilsdonk et al, 2016). Spinal cord MRI is technically challenging since the structure itself is narrow, mobile and flexible (Stroman et al, 2014;Kearney et al, 2015a;De Leener et al, 2017;Muccilli et al, 2018). The smaller volume of lesions therein necessitates the demand for increased spatial resolution (Barry et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis

Ouellette

Treabă

Granberg

et al. 2020

Brain

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We used 7 T MRI to: (i) characterize the grey and white matter pathology in the cervical spinal cord of patients with early relapsing-remitting and secondary progressive multiple sclerosis; (ii) assess the spinal cord lesion spatial distribution and the hypothesis of an outside-in pathological process possibly driven by CSF-mediated immune cytotoxic factors; and (iii) evaluate the association of spinal cord pathology with brain burden and its contribution to neurological disability. We prospectively recruited 20 relapsing-remitting, 15 secondary progressive multiple sclerosis participants and 11 age-matched healthy control subjects to undergo 7 T imaging of the cervical spinal cord and brain as well as conventional 3 T brain acquisition. Cervical spinal cord imaging at 7 T was used to segment grey and white matter, including lesions therein. Brain imaging at 7 T was used to segment cortical and white matter lesions and 3 T imaging for cortical thickness estimation. Cervical spinal cord lesions were mapped voxel-wise as a function of distance from the inner central canal CSF pool to the outer subpial surface. Similarly, brain white matter lesions were mapped voxel-wise as a function of distance from the ventricular system. Subjects with relapsing-remitting multiple sclerosis showed a greater predominance of spinal cord lesions nearer the outer subpial surface compared to secondary progressive cases. Inversely, secondary progressive participants presented with more centrally located lesions. Within the brain, there was a strong gradient of lesion formation nearest the ventricular system that was most evident in participants with secondary progressive multiple sclerosis. Lesion fractions within the spinal cord grey and white matter were related to the lesion fraction in cerebral white matter. Cortical thinning was the primary determinant of the Expanded Disability Status Scale, white matter lesion fractions in the spinal cord and brain of the 9-Hole Peg Test and cortical thickness and spinal cord grey matter cross-sectional area of the Timed 25-Foot Walk. Spinal cord lesions were localized nearest the subpial surfaces for those with relapsing-remitting and the central canal CSF surface in progressive disease, possibly implying CSF-mediated pathogenic mechanisms in lesion development that may differ between multiple sclerosis subtypes. These findings show that spinal cord lesions involve both grey and white matter from the early multiple sclerosis stages and occur mostly independent from brain pathology. Despite the prevalence of cervical spinal cord lesions and atrophy, brain pathology seems more strongly related to physical disability as measured by the Expanded Disability Status Scale.

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Spinal Cord MRI in Multiple Sclerosis

Cited by 17 publications

References 133 publications

Application of Dynamic Enhanced Magnetic Resonance Imaging in the Diagnosis of Hematological Malignancies

Application of Dynamic Enhanced Magnetic Resonance Imaging in the Diagnosis of Hematological Malignancies

Clinical, Radiological and Pathological Characteristics Between Cerebral Small Vessel Disease and Multiple Sclerosis: A Review

7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis

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