Spinal cord self-repair during tail regeneration in Polypedates maculatus and putative role of FGF1 as a neurotrophic factor

Hota, Jutshina; Pati, Sushri Sangita; Mahapatra, Pravati Kumari

doi:10.1016/j.jchemneu.2017.11.001

Cited by 5 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been well-documented that aFGF plays an important role in wound healing (Zheng et al, 2015;Hota et al, 2018;Wang et al, 2018;Kawano et al, 2019). Compared to the lyophilized rh-aFGF currently on the market, the rh-aFGF-loaded carbomer hydrogel has the advantage of increased drug intake and enhanced bioavailability, providing the wound with a "wet healing environment" and avoiding secondary contamination (Hui et al, 2018b).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Toxicity Study of Topical Administration of a Highly-Stable rh-aFGF Carbomer 940 Hydrogel in a Rabbit Skin Wound Model

Zhang

Huang

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

We developed a highly stable recombinant human acidic fibroblast growth factor (rh-aFGF) carbomer 940 hydrogel for wound healing. This study aimed to reveal toxicity target organs and the toxicity dose-response in the long-term administration of rh-aFGF carbomer 940 hydrogel in a rabbit skin wound model. New Zealand rabbits were topically administrated rh-aFGF carbomer 940 hydrogel at a daily dose of 900 IU/cm 2 , 1,800 IU/cm 2 , and 3,600 IU/cm 2 for 28 days. Lyophilized rh-aFGF agent was used as the positive control group. General behavior, serum chemistry, skin irritation, immunogenicity, immunotoxicity, and histopathology were analyzed at designated time points. Results revealed that food intake, body weight, body temperature, heart rate, and eye examinations were all normal, suggesting no obvious toxicity induced by the rh-aFGF hydrogel. Medium and high dose rh-aFGF hydrogel groups and the positive control group displayed increased cell numbers in the local lymph nodes near the site of administration, likely caused mesenteric lymph node follicular hyperplasia, and this observation was alleviated after 14 days of recovery. Immunogenicity studies demonstrated that the serum antibody titer against rh-aFGF increased with the duration and number of drug applications but were not neutralization antibodies. After administration stopped, antibody titer decreased and disappeared in some mice. In summary, the safe dose for long-term administration of rh-aFGF carbomer 940 hydrogel for persistently damaged skin was 900 IU/cm 2 , which is 10 times that of the proposed clinical dosing.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-Term Toxicity Study of Topical Administration of a Highly-Stable rh-aFGF Carbomer 940 Hydrogel in a Rabbit Skin Wound Model

Zhang

Huang

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…4 ). Fibroblast growth factor 1 (FGF1) has obvious neurotrophic support effect and can promote the recovery of neurons after spinal cord injury [ 53 ]. Lv et al found that the decrease of LncRNA Map2K4 expression in spinal cord injury could relieve the competitive inhibition of miR-199a; miR-199a was negatively correlated with the downstream target protein FGF1 [ 54 ].…”

Section: Role Of Lncrnas In the Pathological Process Of Spinal Cord I...mentioning

confidence: 99%

Research Progress of Long Non-coding RNAs in Spinal Cord Injury

Cai

Han

et al. 2022

Neurochem Res

View full text Add to dashboard Cite

Spinal cord injury (SCI) can result in a partial or complete loss of motor and sensory function below the injured segment, which has a significant impact on patients' quality of life and places a significant social burden on them. Long non-coding RNA (LncRNA) is a 200–1000 bp non-coding RNA that has been shown to have a key regulatory role in the progression of a variety of neurological illnesses. Many studies have demonstrated that differentially expressed LncRNAs following spinal cord injury can participate in inflammatory damage, apoptosis, and nerve healing by functioning as competitive endogenous RNA (ceRNA); at the same time, it has a significant regulatory effect on sequelae such neuropathic pain. As a result, we believe that LncRNAs could be useful as a molecular regulatory target in the diagnosis, treatment, and prognosis of spinal cord injury.

show abstract

Mesenchymal stem cell-derived exosomes containing miR-145-5p reduce inflammation in spinal cord injury by regulating the TLR4/NF-κB signaling pathway

Jiang

Zhang

2021

Cell Cycle

View full text Add to dashboard Cite

Spinal cord self-repair during tail regeneration in Polypedates maculatus and putative role of FGF1 as a neurotrophic factor

Cited by 5 publications

References 42 publications

Long-Term Toxicity Study of Topical Administration of a Highly-Stable rh-aFGF Carbomer 940 Hydrogel in a Rabbit Skin Wound Model

Long-Term Toxicity Study of Topical Administration of a Highly-Stable rh-aFGF Carbomer 940 Hydrogel in a Rabbit Skin Wound Model

Research Progress of Long Non-coding RNAs in Spinal Cord Injury

Mesenchymal stem cell-derived exosomes containing miR-145-5p reduce inflammation in spinal cord injury by regulating the TLR4/NF-κB signaling pathway

Contact Info

Product

Resources

About