Spinal Cord Stimulation in the Treatment of Complex Regional Pain Syndrome (CRPS) of the Lower Extremity: A Case Report

A Multicenter, Prospective Trial to Assess the Safety and Performance of the Spinal Modulation Dorsal Root Ganglion Neurostimulator System in the Treatment of Chronic Pain

“…The relief of foot pain is of special interest in this study. Reports of nonvascular neuropathic foot pain relief via SCS are few and small , likely because foot coverage with traditional SCS systems are unable to cover discrete painful regions in the foot without generating extensive extraneous paresthesias or motor side‐effects. Additionally, the pain relief afforded to the feet by SCS is typically limited.…”

Spinal Cord Stimulation in Complex Regional Pain Syndrome Type I of Less Than 12-Month Duration

“…Therefore, the early use of SCS (less than one year) for the management of CRPS was recommended as a strategy to prevent chronicity and possible central sensitization in order to improve pain,functional status, and outcome (9). A favorable outcome of CRPS is reported in some case studies where SCS was used in the first year of the syndrome (10,11). In a retrospective case series describing early SCS intervention in ten consecutive military personnel patients with CRPS of 5‐ to 12‐month duration, significant reduction of pain and daily morphine requirements was reported.…”

Increased efficacy of early spinal cord stimulation in an animal model of neuropathic pain

“…Furthermore, it has been shown that the severity of touch evoked allodynia in patients with CRPS is positively correlated with the progression of the disease (Schwartzman et al, 2009). Indeed, several case studies have reported an improved outcome, when SCS was used in an early stage of the disease (Harney et al, 2005;Verdolin et al, 2007;Saranita et al, 2009). Consequently, severe or long lasting central sensitization predicts a poor outcome for SCS in patients with CRPS-1, where an early intervention could improve the outcome of SCS by limiting or attenuating central sensitization.…”

“…Consequently, severe or long lasting central sensitization predicts a poor outcome for SCS in patients with CRPS-1, where an early intervention could improve the outcome of SCS by limiting or attenuating central sensitization. Indeed, several case studies have reported an improved outcome, when SCS was used in an early stage of the disease (Harney et al, 2005;Verdolin et al, 2007;Saranita et al, 2009).…”