Spinal deformity in children treated for neuroblastoma.

Mayfield, J K; Riseborough, E J; Jaffe, N; Nehme, M E

doi:10.2106/00004623-198163020-00002

Cited by 87 publications

(28 citation statements)

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“…An NWTS analysis (n = 680) also reported a higher prevalence of scoliosis or kyphosis among survivors who had received radiation (51.4%) compared to those who had not (4.1%) (24). The evidence for the association between radiotherapy and spinal malalignment is strengthened by other studies (4, 21–23, 27, 28, 30, 34, 36, 42–55). …”

Section: Resultsmentioning

confidence: 73%

“…Differential effects of radiation are reported based on age cutoffs of six months (51), one year (45), five years (23), or six years (44), depending on the population being studied. Similarly, varied thresholds for radiation dose are reported to increase risk for spinal malalignment including, > 20 Gy (34), > 23 Gy (52), > 24 Gy (28), and > 26 Gy (23). Asymmetric radiation increases the risk of spinal deformity in two ways (27, 34, 47).…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, varied thresholds for radiation dose are reported to increase risk for spinal malalignment including, > 20 Gy (34), > 23 Gy (52), > 24 Gy (28), and > 26 Gy (23). Asymmetric radiation increases the risk of spinal deformity in two ways (27, 34, 47). It is possible that radiation impairs the vertebral growth plate more on one side than the other.…”

Section: Resultsmentioning

confidence: 99%

“…However, because vertebral bodies are small, it is likely difficult to impair only a portion of a vertebra. Two authors have speculated that spinal deformity is the result of tethering in atrophied paraspinal muscles (23, 34). Butler et al .…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

Gawade¹,

Hudson²,

Kaste³

et al. 2015

CPR

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Survivors of childhood cancer are at risk for treatment-related musculoskeletal late effects. Early detection and orthopedic intervention can help ameliorate musculoskeletal late effects and prevent subsequent complications. This systematic review summarizes the literature describing associations between cancer, its treatment, and musculoskeletal late effects. We searched PubMed and Web of Science for English language articles published between January 1970 and December 2012. The search was limited to investigations with at least 15 participants and conducted at least 2 years after completion of therapy for childhood, adolescent, or young adult cancer. Some late skeletal effects, including low bone mineral density, osteonecrosis, slipped capital femoral epiphyses, oncogenic rickets, and hormone-related growth disturbances have been previously reviewed and were excluded, as were outcomes following amputation and limb-salvage procedures. Of 2347 references identified, 30 met inclusion criteria and were retained. An additional 54 studies that met inclusion criteria were found in reference lists of retained studies. Of 84 studies, 60 focused on associations between radiotherapy, six between chemotherapy, and 18 between surgery and musculoskeletal late effects. We found that younger age, higher radiation dosage, and asymmetric or partial bone radiation volume influences the effects of radiation on the musculoskeletal system. Methotrexate and vincristine are associated with long-term muscular strength and flexibility deficits. Laminectomy and chest wall resection are associated with spinal malalignment, and enucleation is associated with orbital deformities among survivors. Radiotherapy, chemotherapy, and surgery are associated with musculoskeletal late effects independently and additively. Associations are additionally influenced by host and treatment characteristics.

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Section: Resultsmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

Gawade¹,

Hudson²,

Kaste³

et al. 2015

CPR

View full text Add to dashboard Cite

show abstract

“…This clinical finding may help differentiate these survivors from those with typically symmetrical growth failure due to GHD, an important clinical consideration in determining who may require further investigation for GHD. Additional growth limitations following spinal radiation may be seen due to scoliosis or kyphosis, which are seen at higher rates in CCS treated with spinal radiation, particularly those treated at younger ages, with higher radiation doses, and with asymmetric radiation [30-32]. …”

Section: Growth Impairment and Short Adult Height Following Exposure mentioning

confidence: 99%

Growth Disturbances in Childhood Cancer Survivors

Antal

Balachandar

2019

Horm Res Paediatr

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Survival from childhood cancer has improved dramatically over the last few decades, resulting in an increased need to address the long-term follow-up and care of childhood cancer survivors. Appropriate linear growth is an important measure of health, with alterations of growth in children and short adult height in those who have completed growth serving as potential indicators of the sequelae of the underlying diagnosis or the cancer treatments. It is therefore critical that clinicians, particularly endocrinologists, be familiar with the patterns of altered growth which may be seen following diagnosis and treatment for childhood cancer. In this article, we will review the growth alterations seen in childhood cancer survivors, focusing on risk factors and considerations in evaluation and care.

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Long-term results of therapy for stage C neuroblastoma

Halperin

1996

J. Surg. Oncol.

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Background The appropriate therapy for Stage C neuroblastoma (NB) is uncertain. Because of the need for information applicable to the development of new randomized trials, we deemed it appropriate to investigate the patient characteristics, survival, patterns of failure, and complications of therapy in these children. Methods Search of the medical records of Duke University Medical Center from 1/1/60 to 3/1/95 disclosed 146 patients with NB, which included 13 Stage C patients. Results Mean age at diagnosis was 3.6 years. Twelve patients had primary abdominal tumors (92%) and one had a thoracic primary (8%). Twelve (92%) of the patients received chemotherapy including cyclophosphamide, 11 (85%), Adriamycin, 6 (46%), cisplatinum, 4 (30%), and VP 16, 4 (30%). All patients received radiotherapy (RT, mean dose administered 22.6 ± 8 Gy). With a mean follow‐up of 8 years, the 10‐year overall survival was 54% and the relapse‐free survival was 46%. Four patients relapsed in the primary operative tumor bed and primary RT field, two relapsed in mediastinal or left supraclavicular lymph nodes as well as distantly following treatment of upper abdominal primaries, and in one the site of relapse is unknown. Long‐term complications of therapy included two children who developed secondary malignancies associated with RT, two girls who developed primary ovarian failure, five children with clinically significant kyphosis and scoliosis, and one who suffered postoperative wound dehiscence following RT. Conclusions Although this study did not include modern techniques of staging with n‐myc amplification and DNA index, the occurrence of next echelon nodal failures gives credence to the continuation of the dialogue concerning the appropriate role of “prophylactic” irradiation to mediastinal and left supraclavicular nodes in locally advanced upper abdominal NB. Documentation of significant long‐term ill effects reinforces the need to critically evaluate the indications for RT. © 1996 Wiley‐Liss, Inc.

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Spinal deformity in children treated for neuroblastoma.

Cited by 87 publications

References 0 publications

A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

Growth Disturbances in Childhood Cancer Survivors

Long-term results of therapy for stage C neuroblastoma

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