Spinal fentanyl vs. sufentanil for post‐operative analgesia after C‐section: a double‐blinded randomised trial

Wilwerth, M.; Majcher, J.L.; Linden, Philippe Van der

doi:10.1111/aas.12738

Cited by 11 publications

(8 citation statements)

References 21 publications

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“…The results of this study showed that when sufentanil and fentanyl were used for analgesia in patients with traumatic brain injury in ICU, the CPOT and RASS scores were significantly reduced, and both groups obtained satisfactory sedation and analgesia effects. Moreover, the frequency of spontaneous breathing in the sufentanil group was significantly reduced at all time points after treatment, which suggests that sufentanil can increase the synchronization of human and machine in patients with mechanical ventilation and make breathing more stable [ 16 ]. The sufentanil group obtained satisfactory sedative and analgesic effects faster, which may be related to the lipophilicity of sufentanil, which is about twice that of fentanyl, and it passes more easily and faster through the blood-brain barrier, so it has a sedative effect stronger than fentanyl.…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Sufentanil and Fentanyl Analgesia in Patients with Traumatic Brain Injury: A Retrospective Study

Xia

Yang

2022

Med Sci Monit

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Background This study aimed to retrospectively assess and compare the safety and efficacy of sufentanil and fentanyl in the treatment of patients with traumatic brain injury. Material/Methods A total of 85 patients with traumatic brain injury from June 2016 to September 2018 were included in this study, and were enrolled into a sufentanil group and a fentanyl group according to different treatment methods. The patients in both groups were assessed with the Critical care Pain Observation Tool (CPOT) for analgesic score, and Richmond Agitation-Sedation Scale (RASS) for sedation score. Results The scores of CPOT and RASS in the 2 groups were significantly lower than before treatment ( P <0.05), but there was no significant difference between the 2 groups ( P >0.05). The heart rate (HR), rate of spontaneous respiration (RR), and mean arterial pressure (MAP) of the 2 groups were significantly lower than before treatment ( P <0.05), and the RR of the sufentanil group was significantly lower than that of the fentanyl group at all time points after treatment ( P <0.001). Conclusions Sufentanil has a rapid onset of effect, and it is safe, stable, and effective for patients with traumatic brain injury in the intensive care unit (ICU). Compared with fentanyl, sufentanil can also effectively shorten mechanical ventilation time, time to obtain satisfactory sedation and analgesia, and the length of hospitalization in the ICU.

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Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Sufentanil and Fentanyl Analgesia in Patients with Traumatic Brain Injury: A Retrospective Study

Xia

Yang

2022

Med Sci Monit

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“…[7] The comparison of intrathecal fentanyl and sufentanil showed that sufentanil provides longer post-operative analgesia without increased incidence of side effects. [89]…”

Section: Intrathecal and Epidural Opioidsmentioning

confidence: 99%

Post-caesarean analgesia: What is new?

2017

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“…Various opioids have been used along with local anesthetics or as sole agents [2]. The administration of opioids in intrathecal space as an adjuvant to local anesthetic was found to provide very good analgesia in various surgical procedures [3,4]. The scientific explanation behind the combination of opioids and local anesthetics intrathecally is, that these two drugs act at different sites and hence provide better analgesia than administration of individual drug alone.…”

Section: Introductionmentioning

confidence: 99%

Intrathecal nalbuphine – Will it gain wider acceptance? – A narrative review

Sethuraman

2017

Egyptian Journal of Anaesthesia

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Background: The main goal of this review article is to elucidate the merits as well as the safety of nalbuphine as an adjunct to local anesthetics in the sub-arachnoid block, so that its usage will increase considerably. Unlike morphine and fentanyl, nalbuphine, a mixed agonist-antagonist opioid, is not commonly used despite its better features such as good duration of analgesia, lack of pruritus, lesser respiratory depression, nausea and vomiting. There is no review article available in the literature that had analyzed ''intrathecal nalbuphine" specifically. The other types of literature available also very few. Methods: This review article is based on few available literatures that had studied the effects of intrathecal nalbuphine. Total results from PubMed search of ''intrathecal nalbuphine" was 29 as on 05 March 2017. Thirteen articles were removed from these 29, as they were not relevant to this topic. Nine more articles were taken from PubMed following an additional search of ''similar articles" to support this article further. Two articles were selected from Google and seven articles from Embase indexed journals were collected after initial search from Google. Two review articles were collected from Cochrane database, although not specific to intrathecal route of administration alone. Conclusion: Nalbuphine is a very useful adjunct to intrathecal local anesthetics because of the good duration of analgesia, anti-pruritic,anti-shivering properties, lesser respiratory depression, nausea, and vomiting. The author hopes that this review article will be a forerunner for many more studies to come in the future, so that its acceptance will become widespread.

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Spinal fentanyl vs. sufentanil for post‐operative analgesia after C‐section: a double‐blinded randomised trial

Abstract: In the conditions of our study, sufentanil 5 μg was the opioid of choice, associated with the best quality of anaesthesia without increased incidence of side effects.

Cited by 11 publications

References 21 publications

Safety and Efficacy of Sufentanil and Fentanyl Analgesia in Patients with Traumatic Brain Injury: A Retrospective Study

Safety and Efficacy of Sufentanil and Fentanyl Analgesia in Patients with Traumatic Brain Injury: A Retrospective Study

Post-caesarean analgesia: What is new?

Intrathecal nalbuphine – Will it gain wider acceptance? – A narrative review

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