Spinal Fluid Clotting Activity: a New Method of Evaluating Neonatal Brain Damage

The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis

“…These data indicate that not only do PEVs have functions in the blood but they can also affect pathologies in these locations within the body. This is particularly important when considering the possibility of PEVs affecting coagulation outside the blood in pathologic conditions [ 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ]. In particular, PEVs may play a large role in the coagulation of lymphatic fluid, which is normally a hypocoagulable fluid due to the paucity of phospholipids [ 107 ].…”

“…Since different stimuli result in different numbers and phenotypic expression/contents of PEVs, it is important to know how PEVs are being generated in different disease states as well as to know how different agonists and therapies affect PEVs. Intriguingly, coagulation can also occur in fluid other than that of blood, including the bone marrow [ 108 ], the CNS [ 109 , 110 , 111 ], the lymphatic system [ 107 , 115 , 116 , 117 , 118 ], and the synovial fluid [ 112 , 113 , 114 , 156 ] in pathologic conditions. This occurs due to leakage of clotting factors and PEVs into these fluids allowing for coagulation, but very little has been studied about the roles of PEVs in coagulation outside the blood.…”