Spinal GABAergic disinhibition allows microglial activation mediating the development of nociplastic pain in male mice

McDonough, Kathleen E; Hammond, Regan; Wang, Jigong; Tierney, Jessica E.; Hankerd, Kali; Chung, Jin Mo; La, Jun–Ho

doi:10.1016/j.bbi.2022.10.013

Cited by 6 publications

(3 citation statements)

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“…Postinjury stimulation of the wounded area was reported to cause pain conversion into NcplP [ 28 ]. Another study by McDonough et al showed that spinal microglia can transmit NcplP [ 122 ]. In both studies, it was emphasized that a sex-dependent mechanism may play a pivotal role in NcplP [ 28 , 103 , 122 ].…”

Section: Primarily Clinical Trialsmentioning

confidence: 99%

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What Do We Know about Nociplastic Pain?

et al. 2023

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Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization. Pathophysiology has not been clearly established with regard to alteration of the concentration of spinal fluid elements, the structure of the white and gray matter of the brain, and psychological aspects. Many different diagnostic tools, i.e., the painDETECT and Douleur Neuropathique 4 questionnaires, have been developed to diagnose neuropathic pain, but they can also be applied for nociplastic pain; however, more standardized instruments are still needed in order to assess its occurrence and clinical presentation. Numerous studies have shown that nociplastic pain is present in many different diseases such as fibromyalgia, complex regional pain syndrome type 1, and irritable bowel syndrome. Current pharmacological and nonpharmacological treatments for nociceptive and neuropathic pain are not entirely suitable for treating nociplastic pain. There is an ongoing effort to establish the most efficient way to manage it. The significance of this field has led to several clinical trials being carried out in a short time. The aim of this narrative review was to discuss the currently available evidence on pathophysiology, associated diseases, treatment possibilities, and clinical trials. It is important that physicians widely discuss and acknowledge this relatively new concept in order to provide optimized pain control for patients.

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Section: Primarily Clinical Trialsmentioning

confidence: 99%

“…Another study by McDonough et al showed that spinal microglia can transmit NcplP [122]. In both studies, it was emphasized that a sex-dependent mechanism may play a pivotal role in NcplP [28,103,122].…”

Section: Primarily Clinical Trialsmentioning

confidence: 99%

What Do We Know about Nociplastic Pain?

et al. 2023

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“…This metabolism process likely involves lipoxygenase (LOX) or cytochrome P450 enzymes [ 64 ]. One study utilizing a mice model discovered that, unlike neuropathic pain, prostaglandins do not contribute significantly to nociplastic pain [ 66 ]. When the metabolism of prostaglandins was blocked through the inhibition of the cyclooxygenase (COX) pathway, the mice demonstrated no significant changes in pain, whereas the inhibition of proinflammatory cytokines did induce a significant decrease in nociplastic pain.…”

Section: Nociplastic Painmentioning

confidence: 99%

Microbiological and Physiological Effects of Pain

Jin

Everett

Abd‐Elsayed

2023

Curr Pain Headache Rep

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Pain is an important innate defense mechanism that can dramatically alter a person’s quality of life. Understanding the microbiological and physiological effects of pain may be important in the pursuit of novel pain interventions. The three descriptors of pain recognized by the International Association for the Study of Pain are nociceptive, neuropathic, and nociplastic pain. Our review examined the current understanding of all three pain types, focusing on the key molecules involved in the manifestation of each type as well as physiological effects. Additionally, we compared the differences in painful and painless neuropathies and discussed the neuroimmune interaction involved in the manifestation of pain.

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