“…Of the 35 included reviews, 24 investigated the effectiveness of spinal manipulation in paediatric clients and produced quantifiable results which could be utilised in the descriptive synthesis (Supplementary File 5 ). Three were focused on treatment for AIS [ 104 , 106 , 107 ], seven on asthma [ 1 , 21 , 45 , 91 , 96 , 98 , 104 ], two for ASD [ 51 , 102 ], two on spinal pain [ 104 , 109 ], four on breastfeeding difficulties for infants [ 28 , 30 , 99 , 104 ], two on CP [ 25 , 104 ], 15 on infantile colic—excessive crying / behaviours [ 1 , 21 , 25 , 26 , 42 , 43 , 66 , 91 , 96 , 98 , 103 , 104 ], four on infantile colic – sleep issues [ 42 , 66 , 91 , 104 ], five on nocturnal enuresis [ 26 , 44 , 46 , 96 , 98 ], three on otitis media [ 98 , 104 , 105 ] and one on torticollis [ 62 ] (see Supplementary File 5 ). Additionally, there were four systematic reviews on adverse events from spinal manipulation [ 73 , 100 , 108 , 110 ] and nine reported on multiple conditions including those mentioned above as well as neck and back pain, and upper cervical dysfunction [ 1 , 21 , 25 , 26 , ...…”