Spinal manual therapy produces rapid onset analgesia in a rodent model

Grayson, Jane; Barton, Tom; Cabot, Peter J.; Souvlis, Tina

doi:10.1016/j.math.2012.02.004

Cited by 25 publications

(22 citation statements)

References 16 publications

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“…15–24 These hypoalgesic effects occur both unilaterally and bilaterally as well as proximally and distally to the manipulation site. Evidence from animal models 25–29 demonstrates that manual therapy applied to rats affects mechanical withdrawal thresholds in areas of the body distant to those being treated, which is consistent with reported clinical findings. Collectively, this clinical and experimental evidence suggests that HVLA-SM alters central processing of sensory input.…”

supporting

confidence: 78%

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive-Specific Lateral Thalamic Neurons

Reed

Sozio

Pickar

et al. 2014

Journal of Manipulative and Physiological Therapeutics

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Objective The objective of this preliminary study was to determine if high-velocity, low-amplitude spinal manipulation (HVLA-SM) thrust duration alters mechanical trunk activation thresholds of nociceptive-specific (NS) lateral thalamic neurons. Methods Extracellular recordings were obtained from 18 NS neurons located in 2 lateral thalamic nuclei (ventrolateral [n = 12] and posterior [n = 6]) in normal anesthetized Wistar rats. Response thresholds to electronic von Frey anesthesiometer (rigid tip) mechanical trunk stimuli applied in 3 lumbar directions (dorsal-ventral, 45° caudal, and 45° cranial) were determined before and immediately after the delivery of 3 HVLA-SM thrust durations (time control 0, 100, and 400 milliseconds). Mean changes in mechanical trunk activation thresholds were compared using a mixed model analysis of variance. Results High-velocity, low-amplitude spinal manipulation duration did not significantly alter NS lateral thalamic neurons’ mechanical trunk responses to any of the 3 directions tested with the anesthesiometer. Conclusions This study is the first to examine the effect of HVLA-SM thrust duration on NS lateral thalamic mechanical response thresholds. High-velocity, low-amplitude spinal manipulation thrust duration did not affect mechanical trunk thresholds.

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supporting

confidence: 78%

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive-Specific Lateral Thalamic Neurons

Reed

Sozio

Pickar

et al. 2014

Journal of Manipulative and Physiological Therapeutics

View full text Add to dashboard Cite

show abstract

“…Evidence from animal models [25][26][27][28][29] demonstrates that manual therapy applied to rats affects mechanical withdrawal thresholds in areas of the body distant to those being treated, which is consistent with reported clinical findings. Collectively, this clinical and experimental evidence suggests that HVLA-SM alters central processing of sensory input.…”

Section: Key Indexing Termssupporting

confidence: 82%

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive Specific Lateral Thalamic Neurons

ReedWilliam

SozioRandall

PickarJoel

et al. 2014

The Journal of Alternative and Complementary Medicine

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Objective-The objective of this preliminary study was to determine if high-velocity, lowamplitude spinal manipulation (HVLA-SM) thrust duration alters mechanical trunk activation thresholds of nociceptive-specific (NS) lateral thalamic neurons.Methods-Extracellular recordings were obtained from 18 NS neurons located in 2 lateral thalamic nuclei (ventrolateral [n = 12] and posterior [n = 6]) in normal anesthetized Wistar rats. Response thresholds to electronic von Frey anesthesiometer (rigid tip) mechanical trunk stimuli applied in 3 lumbar directions (dorsal-ventral, 45° caudal, and 45° cranial) were determined before and immediately after the delivery of 3 HVLA-SM thrust durations (time control 0, 100, and 400 milliseconds). Mean changes in mechanical trunk activation thresholds were compared using a mixed model analysis of variance.Results-High-velocity, low-amplitude spinal manipulation duration did not significantly alter NS lateral thalamic neurons' mechanical trunk responses to any of the 3 directions tested with the anesthesiometer.Copyright © 2014 by National University of Health Sciences.Submit requests for reprints to: William R Reed, DC, PhD, 741 Brady St, Davenport, IA 52803. (william.reed@palmer.edu). Potential Conflicts of Interest No conflicts of interest were reported for this study Contributorship Information Concept development (provided idea for the research): W.R.R. Design (planned the methods to generate the results): W.R.R., J.G.P., R.S.S. Supervision (provided oversight, responsible for organization and implementation, writing of the manuscript): W.R.R. Data collection/processing (responsible for experiments, patient management, organization, or reporting data): W.R.R., R.S.S. Analysis/interpretation (responsible for statistical analysis, evaluation, and presentation of the results): W.R.R., J.G.P., S.M.O., R.S.S. Literature search (performed the literature search): W.R.R., S.M.O., R.S.S. Writing (responsible for writing a substantive part of the manuscript): W.R.R., S.M.O. Critical review (revised manuscript for intellectual content, this does not relate to spelling and grammar checking): W.R.R., J.G.P., S.M.O., R.S.S.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptConclusions-This study is the first to examine the effect of HVLA-SM thrust duration on NS lateral thalamic mechanical response thresholds. High-velocity, low-amplitude spinal manipulation thrust duration did not affect mechanical trunk thresholds. Key Indexing TermsManipulation; Spinal; Thalamus; Nociceptive Neuron; Lumbar Vertebrae; ChiropracticSpinal manipulation has been shown to be effective in treating neck and low back pain. [1][2][3] Not only are the neurophysiological mechanisms by which this occurs unknown, but a lack of knowledge also exists regarding the effects of clinician-controlled mechanical application parameters o...

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“…A influência da manipulação sobre a ativação do sistema opioide endógeno também foi avaliada relativamente à liberação de B-endorfinas 25 , e um possível efeito opioide no sistema nervoso periférico 26 . A melhora da avaliação do limiar da dor à pressão no grupo experimental excedeu o erro padrão de medição (0,01 kg / cm2) relatado para a mecanossensibilidade lombar em pacientes com dor lombar 27 .…”

Section: Conclusãounclassified

Terapia Manual No Tratamento Da Dismenorreia Primária: Revisão Sistemática

Pinho

Monteiro²,

Pimenta³

et al. 2017

Rev Pesq Fisio

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Introdução: No decorrer do período fértil, aproximadamente mais de um milhão de mulheres apresentam um episódio de doença inflamatória pélvica aguda e mais de 100.000 mulheres desenvolvem a infertilidade como consequência desta. A dismenorreia primária é um fenômeno fisiológico doloroso, espasmódico, descrito como cólicas na parte inferior do abdome, pouco antes e/ou durante o período menstrual. Dentre as práticas não farmacológicas, as técnicas da terapia manual, apresentam efeitos significativos no tratamento da dismenorreia primária. Este estudo tem como objetivo reunir evidências científicas a fim de identificar os possíveis impactos da Terapia Manual no tratamento da dismenorreia primária. Materiais e Métodos: Revisão Sistemática de Literatura incluindo ensaios clínicos controlados randomizados das Bases de Dados LILACS, PubMed, PEDro, Bireme e Cochrane. Resultados: Foram encontrados 55 artigos, dos quais 3 corresponderam aos critérios de inclusão. As variáveis de interesse do estudo foram: intensidade da dor, duração da dor, nível de ansiedade, percepção de dor na região lombar, limiar de dor a pressão, níveis de adrenalina, noradrenalina, serotonina, dopamina e descompressão da articulação sacrilíaca. Conclusão: Esta pesquisa sugere que a terapia manual atua de maneira benéfica no tratamento da dismenorreia primária, apresentando melhora em todas as variáveis estudadas.

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Spinal manual therapy produces rapid onset analgesia in a rodent model

Cited by 25 publications

References 16 publications

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive-Specific Lateral Thalamic Neurons

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive-Specific Lateral Thalamic Neurons

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive Specific Lateral Thalamic Neurons

Terapia Manual No Tratamento Da Dismenorreia Primária: Revisão Sistemática

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