Spinal maturation affects vertebral compressive mechanics and vBMD with sex dependence

Nuckley, David J.; Eck, Michael P.; Carter, Jarrod W.; Ching, Randal P.

doi:10.1016/j.bone.2004.04.015

Cited by 21 publications

(9 citation statements)

References 33 publications

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“…Furthermore, each specimen was ascribed a human equivalent age using the skeletal maturity index on computed tomography (CT) scans. 11 The accuracy of this method is within 1 year and, for this experimental study, the specimens ranged in age from 1 to 30 human-equivalent years.…”

Section: Methodsmentioning

confidence: 99%

Neural Space and Biomechanical Integrity of the Developing Cervical Spine in Compression

Nuckley

Nausdle

Eck

et al. 2007

Spine

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The neuroprotective ability of the cervical spine preceding failure appears to be age dependent, where the young spine can produce greater spinal canal occlusions without failure than its adult counterpart. The overall percent of the spinal canal occluded during a compression injury was not age dependent; however, these data reveal the neuroprotective ability of the child spine to be more sensitive as an injury predictor than the biomechanical fracture data.

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Section: Methodsmentioning

confidence: 99%

Neural Space and Biomechanical Integrity of the Developing Cervical Spine in Compression

Nuckley

Nausdle

Eck

et al. 2007

Spine

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“…During mammalian spine development, the chondrification center appears at the embryonic stage and is transformed into chondrified vertebrae continuously at birth [25,26]. Next, endochondral ossification manipulates spinal development gradually after birth and contributes to spinal growth until skeletal maturation [27].…”

Section: Biomed Research Internationalmentioning

confidence: 99%

Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively

Yang

Jian-wen

Lai

et al. 2020

BioMed Research International

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Background. TSC1-related signaling plays a pivotal role in intramembranous and endochondral ossification processes during skeletogenesis. This study was aimed at determining the significance of the TSC1 gene at different stages of spinal development. Materials and Methods. TSC1-floxed mice (TSC1 flox/flox ) were crossed with Prrx1-Cre or BGLAP-Cre transgenic mice or mesenchymal stem cell-and osteoblast-specific TSC1-deficient mice, respectively. Somatic and vertebral differences between WT and Prrx1-TSC1 null mice were examined at 4 weeks after birth. Results. No apparent body size abnormalities were apparent in newborn and 4-week-to 2-month-old mice with BGLAP-Cre driver-depleted TSC1. Vertebral and intervertebral discs displayed strong dysplasia in Prrx1-TSC1 null mice. In contrast, vertebrae were only slightly affected, and intervertebral discs from skeletal preparations displayed no apparent changes in BGLAP-TSC1 null mice. Conclusion. Our data suggest that the TSC1 gene is crucial for endochondral ossification during postnatal spine development but plays discriminative roles at different stages. Mesenchymal stem cell-specific ablation of TSC1 led to severe spinal dysplasia at early stages of endochondral ossification while osteoblast-specific deletion of TSC1 affected vertebrae slightly and had no detectable effects on intervertebral discs.

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“…[40][41][42] The availability of experimental data has lead to increased efforts in the modeling of biological materials (see Redondo and LeSar, 43 for a recent review). Merging of mechanics with anatomy and medicine has been able to generate critical data for understanding the force experienced during automotive accidents, [44][45][46][47] as shown in Fig. 2, and sports injuries, 48 as illustrated in Fig.…”

Section: Investigation Of Organic Materialsmentioning

confidence: 99%

Biological Systems and Materials: A Review of the Field of Biomechanics and the Role of the Society for Experimental Mechanics

Brown¹,

Peterson²,

Grande‐Allen³

2006

Experimental Techniques

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Spinal maturation affects vertebral compressive mechanics and vBMD with sex dependence

Cited by 21 publications

References 33 publications

Neural Space and Biomechanical Integrity of the Developing Cervical Spine in Compression

Neural Space and Biomechanical Integrity of the Developing Cervical Spine in Compression

Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively

Biological Systems and Materials: A Review of the Field of Biomechanics and the Role of the Society for Experimental Mechanics

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