Spinal mediation of descending pain inhibitory mechanisms activated by 2/100-Hz electroacupuncture in the rat tail-flick test

Silva, Josie Resende Torres da; Silva, Marcelo Lourenço da; Prado, Wiliam A.

doi:10.1016/j.arthe.2013.03.002

Cited by 2 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study is the first one proved the relationship between OXT hormone and other neurotransmitters (serotonin and dopamine) in modulating its analgesic action. The significant increase in brain homogenate serotonin level in OXT subgroup (A) of the present study is in agreement with previous animal studies which suggested that serotonergic and oxytocinergic neurotransmission interact anatomically and functionally (Scantamburlo et al, 2009;Montag et al, 2011;Silva et al, 2013). Yaksh et al (2014) found that rats treated with oxytocin have an increased synthesis of 5-HT in the frontal cortex and brain stem.…”

Section: Discussionsupporting

confidence: 82%

“…This goes with Condes-Lara et al (2009) animal study, which suggested that OXT plays an important role in pain modulation and analgesia. Intrathecal OXT produces analgesia in both normal (Silva et al, 2013), neuropathic rats (Juif and Poisbeau, 2013) and in dogs with back pain (Huffmeijer et al, 2012) Juif and Poisbeau, (2013) and Ayar et al (2014) described the pathophysiological mechanism of the analgesic effect of OXT. Juif and Poisbeau (2013) described that OXT stimulates the glutamatergic neurons in lamina II, which recruit GABAergic interneurons resulting in the enhancement of GABAergic and glycinergic spontaneous inhibitory transmissions (Ahmet et al, 2014) ending in presynaptic inhibition of C and Aδ fibers (Condes-Lara et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The period from heat application to tail-flick until the animal withdraws the tail was recorded (Silva et al, 2013).…”

Section: Measurement Of Pain Thresholdmentioning

confidence: 99%

See 2 more Smart Citations

Oxytocin ameliorates the deleterious effect of pain in adult male rats

el‐Rady¹,

Ahmed²,

El-Aziz³

et al. 2017

J. Physiol. Pathophysiol.

View full text Add to dashboard Cite

Oxytocin (OXT) is a neuropeptide with a peripheral role in reproduction, though it may have a central effect. The aim of the study is to verify its cental pathophysiological mechanisms on experimental rats. Rats were divided into control, OXT (which divided into intrathecal OXT and IV OXT subgroups), and antagonist group: OXT and l-glutamate Na + subgroup with measuring of pain threshold, cardiovascular changes, and pain related mediators (OXT, serotonin, and dopamine) and histopathological examination. A significant increase of the pain threshold in rats was observed in intrathecal oxytocin subgroup. The response was absent in IV oxytocin subgroup The analgesic effect of OXT contributes to direct increase of OXT receptors maker in different brain areas and spinal cord and through glutamergic pathway. Besides, OXT induces significant increase in the levels of neurotransmitters related to the pain in serum and brain homogenate of this experimental study. Administration of OXT can counterbalance the pain troubles without major detectable detrimental effects on cardiovascular system.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oxytocin ameliorates the deleterious effect of pain in adult male rats

el‐Rady¹,

Ahmed²,

El-Aziz³

et al. 2017

J. Physiol. Pathophysiol.

View full text Add to dashboard Cite

show abstract

“…The intensity and duration of 2 [17] and 2/100 [18] Hz EA-induced antinociception in the rat tail-flick test were both reduced by intrathecal α 1 and mainly α 2 -adrenergic antagonists, while 100 Hz EA antinociception resists α -adrenergic antagonists [17]. However, the duration of 2, 100, or 2/100 Hz EA-induced antinociception was not changed after desipramine administration.…”

Section: Discussionmentioning

confidence: 99%

“…We have recently utilized intrathecal antagonists of these spinal mediators to confirm that 2 and 100 Hz EA [17] and 2/100 Hz EA [18] activate different descending mechanisms in the spinal cord to induce antinociception in the rat tail-flick test. The present study further comparatively evaluates the effects of intrathecal injection of desipramine [19] and fluoxetine [20] (selective inhibitors of norepinephrine and 5-HT uptake, resp.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture at 2/100 Hz Activates Antinociceptive Spinal Mechanisms Different from Those Activated by Electroacupuncture at 2 and 100 Hz in Responder Rats

Silva

Prado

2013

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

We examined the effects of intrathecal injection of desipramine and fluoxetine (selective inhibitors of norepinephrine and 5-HT uptake, resp.), thiorphan and neostigmine (inhibitors of enkephalinase and acetylcholinesterase, resp.), gabapentin (a GABA releaser), and vigabatrin (an inhibitor of GABA-transaminase) on the antinociception induced by 2 Hz, 100 Hz, or 2/100 Hz electroacupuncture (EA) applied bilaterally to the Zusanli (ST36) and Sanyinjiao (SP6) acupoints using the rat tail-flick test. We show that 2 Hz EA antinociception lasts longer after the administration of drugs that increase the spinal availability of norepinephrine, acetylcholine, or GABA; 100 Hz EA antinociception lasts longer after drug that increases the spinal availability of norepinephrine; 2/100 Hz EA antinociception lasts longer after drugs that increase the spinal availability of endogenous opioids or GABA. We conclude that the antinociceptive effect of 2/100 Hz EA is different from the synergistic effect of alternate stimulation at 2 and 100 Hz because the effect of the former is not changed by increasing the spinal availability of serotonin and lasts longer after the administration of vigabatrin. The combination of EA with drugs that increase the availability of spinal neurotransmitters involved in the modulation of nociceptive inputs may result in a synergistic antinociceptive effect in the rat tail-flick test.

show abstract

Spinal mediation of descending pain inhibitory mechanisms activated by 2/100-Hz electroacupuncture in the rat tail-flick test

Cited by 2 publications

References 30 publications

Oxytocin ameliorates the deleterious effect of pain in adult male rats

Oxytocin ameliorates the deleterious effect of pain in adult male rats

Electroacupuncture at 2/100 Hz Activates Antinociceptive Spinal Mechanisms Different from Those Activated by Electroacupuncture at 2 and 100 Hz in Responder Rats

Contact Info

Product

Resources

About