Spinal Mobility in Axial Spondyloarthritis: A Cross‐Sectional Clinical Study

Mogård, Elisabeth; Lindqvist, Elisabet; Bergman, Stefan; Bremander, Ann

doi:10.1002/msc.1138

Cited by 7 publications

(4 citation statements)

References 45 publications

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“…A recent cross-sectional study aiming to explore the differences regarding mobility in several subgroups of patients with axSpA concluded that gender might not have a major impact in the majority of BASMI components. 23 These findings are in accordance with the absence of gender-specific reference intervals for the definition of normal spinal mobility measures. 19 In another study performed with the DESIR cohort, HLA-B27 was associated with axial inflammation, less delay in diagnosis and decreased disease activity measured either by ASDAS-CRP or Bath Ankylosing Spondylitis Disease Activity Index.…”

Section: Discussionsupporting

confidence: 80%

“…However, disease duration may have a more significant impact on mobility in late disease. 23 Structural damage to the hips was independently associated with worse BASMI but not with maximal intermalleolar distance (non-significant association but numerically in the same direction as with BASMI). However, in the sensitivity analysis with purely axial sites, structural damage to the hips was also independently associated with worse maximal intermalleolar distance.…”

Section: Discussionmentioning

confidence: 85%

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Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort

et al. 2020

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ObjectiveTo investigate the determinants of impaired spinal and hip mobility in patients with early axial spondyloarthritis (axSpA).MethodsFive-year longitudinal data from the DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR) cohort were analysed. Associations were investigated using generalised estimating equations, using Bath Ankylosing Spondylitis Metrology Index (BASMI) linear or each of the five components of BASMI as dependent variables, and clinical and demographic variables as independent variables in univariable models. Multivariable analyses were performed, adjusting for potential confounders.ResultsData from 644 patients and 5152 visits were analysed. Higher BASMI values were independently and positively associated with Ankylosing Spondylitis Disease Activity Score C reactive protein (ASDAS-CRP) (adjusted B (adjB)=0.21; 95% CI=0.15 to 0.28), MRI spinal inflammation score (adjB=0.11; 95% CI=0.04 to 0.19), enthesitis score (adjB=0.02; 95% CI=0.01 to 0.04) and age (adjB=0.02; 95% CI=0.01 to 0.03). All BASMI components were independently associated with ASDAS-CRP and MRI spinal inflammation, except for maximal intermalleolar distance (reflecting hip mobility), which was not associated with MRI spinal inflammation.ConclusionIn early axSpA, spinal mobility impairment is independently determined by clinical disease activity, MRI spinal inflammation, enthesitis and age. The influence of spinal inflammation prevails in early axSpA, as opposed to spinal structural damage, which may become more relevant in later disease stages.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 85%

Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort

et al. 2020

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“…Thoracic and lumbar mobility is restricted in AS [29]. Larger tragus to wall distance shows worse spinal/upper cervical posture.…”

Section: Discussionmentioning

confidence: 99%

Can the Second to Fourth Digit Ratio (2D : 4D) Be a Marker to Determine Ankylosing Spondylitis Disease Activity?

et al. 2019

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Objective. The length ratio of the index finger (2D) to the ring finger (4D) (2D : 4D ratio) is considered a biomarker of prenatal sex hormone exposure. The 2D : 4D ratio is influenced by prenatal androgen and estrogen levels. Because ankylosing spondylitis (AS) influences men more frequently and severely than women, androgens are proposed to be related to AS pathogenesis. Estrogens have immune-modulating effects and reduce AS disease activity. The aim of this study was to assess the relationship between 2D : 4D ratio and AS disease activity. Material and Methods. In this study, 167 (43 female) patients diagnosed with AS were studied. The lengths of the second and fourth fingers were measured using a digital caliper. The 2D : 4D ratio was found by dividing the length of the second finger by the length of the fourth finger. AS disease activity was assessed with the Turkish version of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). AS functional status was assessed with Bath Ankylosing Spondylitis Functional Index (BASFI). L-Schober, tragus to wall distance, finger to floor distance, and chest expansion were used to evaluate mobility. Results. In female patients, the right hand 2D : 4D ratios were higher than those in male patients. Biologic drug use was more frequent in males. The BASDAI scores were higher in female patients than in male patients. There were significant negative correlations between right and left hand 2D : 4D ratio and BASFI and BASDAI in female patients. There was no significant correlation between the 2D : 4D ratio and BASFI or BASDAI in male patients. We found a positive correlation between L-Schober and right hand 2D : 4D and a negative correlation between the left hand 2D : 4D ratio and finger to floor distance in female patients with AS. Conclusion. The 2D : 4D ratio of the right and left hand was low in female patients with high BASFI and BASDAI and low spinal mobility (L-Schober) was also linked to low female 2D : 4D. The lack of strong associations between 2D : 4D and AS in male patients may have resulted from their higher use of biologics.

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“…However, intermalleolar distance is included in the BASMI (22) and is therefore often reported as an outcome measure in studies with axSpA. Spinal mobility is known to be influenced by age (17,25,26), height (17,26), sex (25,26) and BMI (26) in the general population as well as in patients with axSpA (32)(33)(34)(35). In our population, patients with axSpA were younger, taller, more often men and had lower BMI than patients with other causes of chronic back pain, which may have influenced the results.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Impaired Spinal Mobility in Patients with Chronic Back Pain Compared to Patients with Early Axial Spondyloarthritis

Fongen

Dagfinrud²,

Berg

et al. 2018

J Rheumatol

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Spinal Mobility in Axial Spondyloarthritis: A Cross‐Sectional Clinical Study

Cited by 7 publications

References 45 publications

Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort

Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort

Can the Second to Fourth Digit Ratio (2D : 4D) Be a Marker to Determine Ankylosing Spondylitis Disease Activity?

Frequency of Impaired Spinal Mobility in Patients with Chronic Back Pain Compared to Patients with Early Axial Spondyloarthritis

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