Spinal nephroblastoma in an Irish wolfhound : case report

Vaughan-Scott, T.; Goldin, Judah; Jw, Nesbit

doi:10.4102/jsava.v70i1.746

Cited by 12 publications

(13 citation statements)

References 6 publications

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“…Interestingly, there are several published case reports of canine intraspinal nephroblastoma, usually associated with neurologic deficits. 13,15,23,26,29 These tumors are thought to result from NRs trapped between the dura and the developing spinal cord. 26 In contrast to humans, these canine tumors tend to be located in the lower thoracic region, which is one of the areas in which the metanephros comes closest to the spinal cord (Dr. Bruce Beckwith, personal communication).…”

Section: Discussionmentioning

confidence: 99%

Lumbosacral Ectopic Nephrogenic Rest Unassociated With Spinal Dysraphism

Horenstein

Manci²,

Walker³

et al. 2004

The American Journal of Surgical Pathology

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Nephrogenic rests (NRs) are thought to originate from persistent nephrogenic blastema and are considered precursor lesions of Wilms' tumor (WT). These rests usually occur as perilobar and intralobar lesions in the kidney and, rarely, in ectopic sites. We report a midline lumbosacral ectopic NR in a healthy full-term newborn male with no family history of WT or WT-associated syndromes. The NR presented as a soft polypoid mass covered by normal skin. An MRI study revealed no lumbosacral spine abnormalities and no communication with the vertebral canal. The resected mass measured 3 cm and contained fat and had a central 1.2-cm solid nodule. The nodule was composed of blastema, epithelial elements (mature tubules and nephrons), and abundant stroma. No other somatic tissue elements were identified after complete microscopic examination. There are 4 cases of NRs reported in the lumbosacral area associated with spinal dysraphism, and only 2 cases, in addition to our report, unassociated with spinal abnormalities. The pathogenesis of heterotopic immature nephrogenic tissue remains a source of conjecture and speculation. If these lesions are heterotopic rests, their potential for neoplastic progression is probably quite limited, but if a monodermal teratoma, then more scrupulous clinical follow-up is warranted.

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Section: Discussionmentioning

confidence: 99%

Lumbosacral Ectopic Nephrogenic Rest Unassociated With Spinal Dysraphism

Horenstein

Manci²,

Walker³

et al. 2004

The American Journal of Surgical Pathology

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“…Canine spinal cord nephroblastoma (CSN) are rare central nervous system neoplasms that have a predilection to occur in dogs between 6 months and 3 years of age 1–12 but have been reported in dogs as old as 7 years 1 . Nephroblastoma, also called Wilms' tumor, represents the most common renal tumor in children, 13 but an extrarenal, spinal location is extremely rare 14 .…”

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Canine Spinal Nephroblastoma: Long‐Term Outcomes Associated with Treatment of 10 Cases (1996–2009)

et al. 2011

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“…68(12): 1383-1385, 2006 Nephroblastoma of the spinal cord is a rare neoplasm in young dogs. Myelography for diagnosis of spinal neoplasm has been described [3,4,11], but more recently, there have been some case reports on the magnetic resonance imaging (MRI) features of nephroblastoma in dogs [5,8]. This paper describes the MRI, surgical treatment and histopathology of canine spinal cord nephroblastoma with progressive hindlimb paresis and ataxia.…”

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Spinal Nephroblastoma in a Miniature Dachshund

Nakade

Inoue

Shimazaki

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. A 2-year-old castrated miniature Dachshund dog was presented to the Rakuno Gakuen Veterinary Teaching Hospital for diagnosis of progressive hindlimb paresis and ataxia. There was no thoracolumbar intervertebral disk hernia and magnetic resonance imaging revealed an intramedullary spinal cord lesion at the ninth and tenth thoracic vertebrae. Following surgical excision of the neoplasm, there was minor amelioration of neurological signs, but forelimb function was not recovered. The extracted tumor was histopathlogically diagnosed as spinal nephroblastoma. KEY WORDS: canine, magnetic resonance imaging (MRI), spinal nephroblastoma.J. Vet. Med. Sci. 68(12): 1383-1385, 2006 Nephroblastoma of the spinal cord is a rare neoplasm in young dogs. Myelography for diagnosis of spinal neoplasm has been described [3,4,11], but more recently, there have been some case reports on the magnetic resonance imaging (MRI) features of nephroblastoma in dogs [5,8]. This paper describes the MRI, surgical treatment and histopathology of canine spinal cord nephroblastoma with progressive hindlimb paresis and ataxia.A 2-year-old castrated miniature Dachshund dog was referred to the Rakuno Gakuen Veterinary Teaching Hospital for diagnosis of progressive hindlimb paresis and ataxia. The dog had sudden onset of left hindlimb lameness 3 weeks earlier. He was treated with oral prednisolone and intravenous methyrprednisolone, but there was no improvement for three weeks.Right hindlimb paresis appeared during the fourth week, indicating that the bilateral hindlimb paresis and ataxia were progressive. Neurological examination revealed proprioceptive, hopping and placing deficits of the left and right hindlimbs. Patellar and pedal reflexes were normal or slightly asthenic. The forelimb was normal and the hindlimb was positive for upper motor neuron sign. Based on clinical neurologic examination, an upper motor neuron third thoracic to third lumbar spinal cord lesion was suspected.Survey radiographs of the entire spine were normal. The dog was anesthetized and imaged in dorsal recumbency using a 0.2-Tesla MR scanner (Signa Profile Open Sprit, GE Yokogawa Medical Systems, Tokyo, Japan) with a surfacearray human extremity coil. T2-weighted and T1-weighted images were obtained in the transvervse and sagittal planes at slice thicknesses of 2.7 and 3.5 mm.T2-weighted, midline sagittal slices revealed an abnormal region in the spinal cord at the ninth and tenth thoracic vertebrae (Fig. 1). The spinal cord lesion was isointense relative to normal spinal cord on T1-weighted MRI (Fig. 2). On enhanced T1-weighted midline sagittal images after intravenous administration of the meglumine gadopentetate (Gd; Magnebisto Nihon Shering Inc., Osaka. 0.1 mmol/kg body weight), the lesion was enhanced and observed at the ninth and tenth thoracic vertebrae. The enhanced lesion was 27 mm in length (Fig. 3). On transverse images, the mass occu-

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Spinal nephroblastoma in an Irish wolfhound : case report

Cited by 12 publications

References 6 publications

Lumbosacral Ectopic Nephrogenic Rest Unassociated With Spinal Dysraphism

Lumbosacral Ectopic Nephrogenic Rest Unassociated With Spinal Dysraphism

Canine Spinal Nephroblastoma: Long‐Term Outcomes Associated with Treatment of 10 Cases (1996–2009)

Spinal Nephroblastoma in a Miniature Dachshund

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