Spinal neurinomas: retrospective analysis and long-term outcome of 179 consecutively operated cases and review of the literature

Conti, P; Pansini, Gastone; Mouchaty, H; Capuano, Christian; Conti, R

doi:10.1016/s0090-3019(03)00537-8

Cited by 352 publications

(300 citation statements)

References 56 publications

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“…Conti et al [17] and Mazel et al [18] have reported similar rates of survival after surgery in a small number of patients with spinal MPNSTs. We believe that our high recurrence and low survival rates can be explained by incomplete tumour removal.…”

Section: Discussionmentioning

confidence: 80%

Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors

Zhu

Liu

et al. 2011

Eur Spine J

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Background and objectives To summarise our experience treating patients with spinal malignant peripheral nerve sheath tumours (MPNSTs). Methods We retrospectively reviewed the records of patients diagnosed with spinal MPNSTs who received surgical treatment from January 1998 to December 2009. Results Postoperative follow-up data were available for 14/16 patients with spinal MPNSTs (7 men, 7 women; median age = 44 years [range: 23-68 years]). Eight of 14 (57.1%) patients had primary and 6/14 (42.9%) recurrent MPNSTs. A total of 12/14 (85.7%) patients underwent total tumour resection, whereas 2/14 (14.3%) patients underwent subtotal tumour resection. Malignancies were graded low in 4 (28.6%) and high in 10 (71.1%) cases. A total of 12/14 (85.7%) patients experienced tumour recurrence and 10/14 (71.4%) patients died during the course of follow-up. The 0.5-1-, 3-, and 5-year survival rates were 64.3, 48.2, 32.1, and 21.4%, respectively. Overall survival was significantly associated with tumour malignant degree (P = 0.012).Conclusion Diagnosis of spinal MPNSTs should be made with reference to clinical, radiological, and pathological findings. Surgical resection is the best available option for treating spinal MPNST; however, postoperative prognosis is poor.

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Section: Discussionmentioning

confidence: 80%

Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors

Zhu

Liu

et al. 2011

Eur Spine J

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“…Calcification is the usual degenerative change, but ossification is a rare degenerative variant 7,9 . These degenerative changes are thought to be the result of the long-term progression of this tumour 10 . They are usually located deep in the head and neck, thorax, retroperitoneum, pelvis and extremities of elderly patients.…”

Section: Discussionmentioning

confidence: 99%

“…A solitary schwannoma will rarely show malignant degeneration. The risk is higher for patients with neurofibromatosis-2 10 .…”

Section: Discussionmentioning

confidence: 99%

Giant solitary ancient schwannoma of the cervico-thoracic spine: a case report and review of the literature

Mwaka¹,

Senyonjo²,

Kakyama³

et al. 2013

OA Case Reports

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“…Schwannomas typically originate from the dorsally situated sensory nerve root and rarely from the ventral motor root. 2,8) In cases of tumors derived from the motor root, direct stimulation can be applied to judge whether that nerve root is functional or not (Case 2). Even if the nerve was damaged, increased intensity to 5-6 mA usually suffices.…”

Section: Discussionmentioning

confidence: 99%

Utility of Direct Stimulation of Roots in Spinal Surgery

Takeda

Yamaguchi

Morishige

et al. 2011

Neurol. Med. Chir.(Tokyo)

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Prevention of postoperative neurological deficits is a major concern of spinal surgeons and has led to the introduction and current development of intraoperative neurophysiological monitoring. We have used motor evoked potentials and somatosensory evoked potentials as routine monitoring techniques and, in some cases, added optional methods such as direct stimulation of nerve roots and spinal evoked potentials. We report our experience of direct nerve root stimulation as an optional monitoring method during spinal surgeries in 7 patients with lesions affecting the proximal nerve roots aged from 1 day to 78 years (mean 23.5 years). Four patients had anomalous lesions, two had spinal nerve root schwannomas, and one had a far-lateral lumbar disc herniation. Direct stimulation was used for detection of motor nerve roots in the anomalous lesions and schwannomas, and to distinguish the nerve root from the paraspinal soft tissues in the case of a far-lateral herniated disc at the L5-S1 level. Although some patients had slight transient neurological symptoms such as motor weakness and sensory disturbance, none developed severe permanent neurological impairment. Direct stimulation allows detection of the motor nerve during spinal surgery in real time. Our limited experience suggests that the direct stimulation technique could reduce the risk of motor or vesicorectal disturbance after surgery of lesions affecting or involving the spinal nerve roots.

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Spinal neurinomas: retrospective analysis and long-term outcome of 179 consecutively operated cases and review of the literature

Cited by 352 publications

References 56 publications

Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors

Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors

Giant solitary ancient schwannoma of the cervico-thoracic spine: a case report and review of the literature

Utility of Direct Stimulation of Roots in Spinal Surgery

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