Spinal Pain, Chronic Health Conditions and Health Behaviors: Data from the 2016–2018 National Health Interview Survey

Luca, Katie de; Tavares, Patrícia; Yang, Haiou; Hurwitz, Eric L.; Green, Bart N.; Dale, Hannah; Haldeman, Scott

doi:10.3390/ijerph20075369

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…With a lifetime prevalence rate estimated at 70% (Ramanathan et al., 2018 ; Rundell et al., 2017 ; Williams et al., 2018 ), spinal pain has been closely linked with several comorbidities impacting quality of life (de Luca et al., 2023 ; Whitlock et al., 2017 ). Even though we were unable to explore this directly in this study, this association is likely attributed to the disability linked to spinal pain predisposing patients to a more sedentary lifestyle—a primary risk factor contributing to a rise in chronic ill health in later life (Thompson, 2020 ; Wang et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Cognition is selectively impaired in males with spinal pain: A retrospective analysis of data from the Longitudinal Study of Ageing Danish Twins

Byfield,

Stacey,

Bailey

2024

Experimental Physiology

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Cognitive decline and spinal pain (back pain [BP] and neck pain [NP]) represent a major public health challenge, yet the potential relationship between them remains elusive. A retrospective analysis of the Longitudinal Study of Ageing Danish Twins was performed to determine any potential relationships between BP/NP and cognitive function adjusting for age, sex, educational and socioeconomic status. A total of 4731 adults (2788 females/1943 males) aged 78 ± 6 (SD) years were included in the analysis. We observed a 1‐month prevalence of 25% with BP, 21% with NP and 11% for combined BP/NP. While there were no differences in cognition scores for males and females reporting combined BP/NP, compared to those without combined BP/NP (34.38 points [95% confidence interval (CI) = 31.88, 36.88] vs. 35.72 points [95% CI = 35.19, 36.26]; P = 0.180; and 35.72 points [95% CI = 35.19, 36.26] vs. 35.85 points [95% CI = 35.39, 36.31]; P = 0.327; for male and females, respectively), an adjusted analysis revealed that males with combined BP/NP presented with lower cognitive scores compared to males without combined BP/NP (81.26 points [95% CI = 73.80, 88.72] vs. 79.48 points [95% CI = 70.31, 88.66]; P = 0.043). The findings of this hypothesis‐generating study may highlight a potential sex‐specific association between spinal pain and later‐life neurodegeneration.

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Section: Discussionmentioning

confidence: 99%

Cognition is selectively impaired in males with spinal pain: A retrospective analysis of data from the Longitudinal Study of Ageing Danish Twins

Byfield,

Stacey,

Bailey

2024

Experimental Physiology

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“…The 2015 Global Burden of Disease study underscored SP as a paramount contributor to disability globally, especially affecting individuals aged 25–64 ( GBD 2015 Disease and Injury Incidence and Prevalence Collaborators, 2016 ). Consequently, healthcare costs for SP treatment soared, reaching an estimated $134.5 billion in the United States in 2020 ( de Luca et al, 2023 ). The pressing need for effective prevention and treatment strategies for SP is a critical concern in the realm of global public health.…”

Section: Introductionmentioning

confidence: 99%

Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis

Hong,

Chen,

Zhou

et al. 2024

Front. Microbiol.

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BackgroundObservational studies have hinted at a correlation between the gut microbiota and spinal pain (SP). However, the impact of the gut microbiota on SP remains inconclusive.MethodsIn this study, we employed a two-sample Mendelian randomization (MR) analysis to explore the causal relationship between the gut microbiota and SP, encompassing neck pain (NP), thoracic spine pain (TSP), low back pain (LBP), and back pain (BP). The compiled gut microbiota data originated from a genome-wide association study (GWAS) conducted by the MiBioGen consortium (n = 18,340). Summary data for NP were sourced from the UK Biobank, TSP from the FinnGen Biobank, and LBP from both the UK Biobank and FinnGen Biobank. Summary data for BP were obtained from the UK Biobank. The primary analytical approach for assessing causal relationships was the Inverse Variance Weighted (IVW) method, supplemented by various sensitivity analyses to ensure result robustness.ResultsThe IVW analysis unveiled 37 bacterial genera with a potential causal relationship to SP. After Benjamini-Hochberg corrected test, four bacterial genera emerged with a strong causal relationship to SP. Specifically, Oxalobacter (OR: 1.143, 95% CI 1.061–1.232, P = 0.0004) and Tyzzerella 3 (OR: 1.145, 95% CI 1.059–1.238, P = 0.0007) were identified as risk factors for LBP, while Ruminococcaceae UCG011 (OR: 0.859, 95% CI 0.791–0.932, P = 0.0003) was marked as a protective factor for LBP, and Olsenella (OR: 0.893, 95% CI 0.839–0.951, P = 0.0004) was recognized as a protective factor for low back pain or/and sciatica. No significant heterogeneity or horizontal pleiotropy was observed through alternative testing methods.ConclusionThis study establishes a causal relationship between the gut microbiota and SP, shedding light on the “gut-spine” axis. These findings offer novel perspectives for understanding the etiology of SP and provide a theoretical foundation for potential interventions targeting the gut microbiota to prevent and treat SP.

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“…Treatment options for chronic spine pain after injuries in adolescence followed by multiple decades of suffering prior to successful treatment are not found in the medical literature [ 3 , 4 ]. Due to the near impossible design of such long-term investigations, there are no four-decade or longer studies, randomized controlled clinical trails (RCTs), or others that could be found in patients injured in their early teen years and who suffer from spine pain, loss of range of motion (ROM) and disability.…”

Section: Introductionmentioning

confidence: 99%

Chronic Widespread Spinal Pain (CWSP) Alleviated With Chiropractic Biophysics®: A Case Report With Three-Year Follow-Up

Haas,

Fortner,

Oakley

et al. 2024

Cureus

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The aim of this case report is to provide clinicians with an option for the treatment of spine pain, spine disorders caused or complicated by abnormal spine alignment, and failed prior interventions for pain and suffering with a conservative protocol. Multi-decade chronic widespread pain (CWSP), low back pain (LBP) headache (HA), and neck pain (NP) cause significant disability and reduced quality of life across all socio-economic and societal categories. Treatment options for decades-old long-term pain with good outcomes are uncommon with non-surgical and surgical interventions. Herein is a single case of positive outcomes with Chiropractic BioPhysics ® (CBP ® )protocol and long-term follow-up. A 60-year-old male with a lifting injury working on a farm at age 12 suffered for decades with LBP, mid-back pain (MBP), NP, HAs, radiculopathy, and poor health-related quality of life (HRQoL). Prior over-the-counter (OTC) medications with diminishing results over 48 years were reported. The patient had multiple abnormal patient-reported outcomes (PROs) as well as measured postural and spine structural abnormalities at the initial assessment. Following 12 treatments, PROs and other measures improved dramatically. Continued brief treatment showed continued progress followed by no treatment beyond continued home exercises and home postural orthoses. All subjective and objective outcome measures improved at one-year follow-up and remained long-term. Improvements in sagittal and coronal postural balance with improved spine alignment, better PROs, and measurably improved HRQoLs were found at one- and three-year follow-ups from the initial evaluation. Chronic NP, LBP, MBP, and extremity pain with altered sensation, loss of function, and failed drug therapy are common across the globe and combined represent the greatest contributors to disability and the global burden of disease (GBD). Economic, efficacious, repeatable, and reliable methods for treating pain will reduce GBD and improve PROs. Larger studies of CBP ® methods for multi-decade chronic pain are challenging; however, continued case reports and RCTs for similar conditions are warranted.

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Spinal Pain, Chronic Health Conditions and Health Behaviors: Data from the 2016–2018 National Health Interview Survey

Cited by 13 publications

References 25 publications

Cognition is selectively impaired in males with spinal pain: A retrospective analysis of data from the Longitudinal Study of Ageing Danish Twins

Cognition is selectively impaired in males with spinal pain: A retrospective analysis of data from the Longitudinal Study of Ageing Danish Twins

Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis

Chronic Widespread Spinal Pain (CWSP) Alleviated With Chiropractic Biophysics®: A Case Report With Three-Year Follow-Up

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