Spinal pharmacology of antinociception produced by microinjection of μ or δ opioid receptor agonists in the ventromedial medulla of the rat

Hurley, Robert W.; Banfor, Patricia N.; Hammond, Donna L.

doi:10.1016/s0306-4522(03)00041-1

Cited by 42 publications

(34 citation statements)

References 35 publications

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“…2) The RVM provides most of the serotonin found in the spinal cord dorsal horn (Dahlstrom A and Fuxe, 1965;Satoh et al, 1980;Bowker et al, 1981;Jensen and Yaksh, 1984;Hammond et al, 1985;Ruda et al, 1986;Heinricher et al, 1999;Gilbert and Franklin, 2001;Hurley et al, 2003;Buhler et al, 2004). 3) An efferent connection from the LH to the RVM exists (Berk and Finkelstein, 1982;Saper et al, 1979;Hosoya, 1980) and we identified neuron profiles immunoreactive for SP that project to the RVM (Fig.…”

Section: Discussionmentioning

confidence: 90%

“…The most likely nuclei candidates for LH-mediated serotonin input to the spinal cord are found in the rostral ventromedial medulla (RVM; the nucleus raphe magnus and the nucleus reticularis gigantocellularis pars alpha), an area known to provide most of the serotonin to the spinal cord dorsal horn and to produce antinociception when activated (Dahlstrom A and Fuxe, 1965;Satoh et al, 1980;Bowker et al, 1981;Rivot et al, 1982;Jensen and Yaksh, 1984;Hammond et al, 1985;Ruda et al, 1986;Heinricher et al, 1999;Gilbert and Franklin, 2001;Hurley et al, 2003;Buhler et al, 2004). Inactivating the RVM by lidocaine microinjection or ibotenic acid lesion significantly increases the electrical stimulation levels needed in the LH to achieve antinociception in male rats .…”

Section: Introductionmentioning

confidence: 99%

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Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla

Holden

Pizzi

2008

Brain Research

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla

Holden

Pizzi

2008

Brain Research

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“…Notwithstanding the exemplary opioids receptors, various different receptors are influenced by opioids both in the central and the peripheral nervous system (7,8,13,14). On the other hand various studies have shown structural similarities between opioids and local anesthetic receptors in the spinal cord in some parts (15)(16)(17). By the way we suggest for further studies for demonstration of the clinical finding of a shorter duration of intrathecal local anesthetic block in those with changed pharmacokinetics especially the opium abusers who can help to our comprehension of pain control mechanism in the central nervous system and also transduction (18).…”

Section: Discussionmentioning

confidence: 99%

Effect of Fentanyl in Spinal Anesthesia With Bupivacaine in Opium Abusers

Zirak¹,

Soltani²,

Javdani³

et al. 2014

Razavi Int J Med

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Background: Spinal anesthesia is a common procedure in the anesthesia. In some studies it has been shown that chronic use of opioids is associated with shorter duration of spinal anesthesia when local anesthetics are applied. Objectives: This trial was conducted in order to determine effect of fentanyl on the duration of spinal block by bupivacaine in chronic opium abusers who undergo spinal anesthesia and have lower thresholds for pain. Patients and Methods:This study was a randomized clinical trial in which 50 opium abusers (25 patients in each group) undergoing lower extremity orthopedic surgeries with spinal anesthesia were selected. The patients were randomly divided into two groups. The study group received 15 mg hyperbaric bupivacaine 0.5% plus 25 µg fentanyl, while the control group received 15mg hyperbaric bupivacaine 0.5% plus 0.25 mL normal saline. Results: All randomly selected cases were male (44.7 ± 13.6 year). The mean duration of sensory block was much longer in the study group (87.8 ± 7.22 minutes) in comparison with the control group (70.47 ± 5.45 minutes) (P < 0.001). There was no statistically significant difference between the two groups regarding their age and duration of surgery. Conclusions: Bupivacaine administration in spinal anesthesia for spinal block has a shortened duration in comparison to the combination of bupivacaine and fentanyl in chronic opium abusers.

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“…The MOR agonist DAMGO (0.5 mg/0.3 ml; Ragnauth et al, 2000;Hurley et al, 2003;Gonzalez-Nicolini et al, 2003) and the MOR antagonist CTAP (1 mg/0.3 ml; Gonzalez-Nicolini et al, 2003;Tang et al, 2005;Tershner and Helmstetter, 2000) were obtained from Sigma-Aldrich (St Louis, MO) and prepared in 0.9% sterile saline. The non-competitive MOR antagonist FNA (4 mg/0.3 ml; Ward et al, 1982Ward et al, , 1985Negus et al, 1993;Primeaux et al, 2006) was prepared in 15% cyclodextran-0.9% saline and was injected at least 24 h (plus maze) or 7 days (burying) before testing.…”

Section: Drugs and Microinjectionsmentioning

confidence: 99%

The Role of Amygdalar Mu-Opioid Receptors in Anxiety-Related Responses in Two Rat Models

Wilson

Junor

2008

Neuropsychopharmacol

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Amygdala opioids such as enkephalin appear to play some role in the control of anxiety and the anxiolytic effects of benzodiazepines, although the opioid receptor subtypes mediating such effects are unclear. This study compared the influences of mu-opioid receptor (MOR) activation in the central nucleus of the amygdala (CEA) on unconditioned fear or anxiety-like responses in two models, the elevated plus maze, and the defensive burying test. The role of MORs in the anxiolytic actions of the benzodiazepine agonist diazepam was also examined using both models.

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Spinal pharmacology of antinociception produced by microinjection of μ or δ opioid receptor agonists in the ventromedial medulla of the rat

Cited by 42 publications

References 35 publications

Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla

Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla

Effect of Fentanyl in Spinal Anesthesia With Bupivacaine in Opium Abusers

The Role of Amygdalar Mu-Opioid Receptors in Anxiety-Related Responses in Two Rat Models

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