Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats
Abstract:Objective: The phytohormone abscisic acid (ABA) as a signaling molecule exists in various types of organisms from early multicellular to animal cells and tissues. It has been demonstrated that ABA has an antinociceptive effect in rodents. The present study was designed to assess the possible role of PKA and phosphorylated ERK (p-ERK) on the antinociceptive effects of intrathecal (i.t.) ABA in male Wistar rats. Methods: The animals were cannulated intrathecally and divided into different experimental groups … Show more
“…Recent data have demonstrated ABA effects on pain. Intrathecal administration of ABA increased pain threshold in male rats and this anti-nociceptive effect was mediated by PKA activation [167] . Furthermore, ABA effects on pain sensitivity were completely abrogated when animals received intracerebroventricular naloxone (opioid receptors antagonist), thus the analgesic effect of the phytohormone could be carried out by opioid receptors activation [168] .…”
Section: Abscisic Acid: Insulin Sensitizer and Anti-inflammatory Nutraceuticalmentioning
“…Recent data have demonstrated ABA effects on pain. Intrathecal administration of ABA increased pain threshold in male rats and this anti-nociceptive effect was mediated by PKA activation [167] . Furthermore, ABA effects on pain sensitivity were completely abrogated when animals received intracerebroventricular naloxone (opioid receptors antagonist), thus the analgesic effect of the phytohormone could be carried out by opioid receptors activation [168] .…”
Section: Abscisic Acid: Insulin Sensitizer and Anti-inflammatory Nutraceuticalmentioning
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