2019
DOI: 10.3390/ani9090693
|View full text |Cite
|
Sign up to set email alerts
|

Spinal Reactive Oxygen Species and Oxidative Damage Mediate Chronic Pain in Lame Dairy Cows

Abstract: Simple SummaryChronic inflammatory diseases could impact central nervous system homeostasis, being oxidative damage of the dorsal horn, a relevant mechanism mediating central sensitization. Chronic inflammatory lameness in dairy cows is a painful condition that affects animal welfare, affecting dairy production worldwide. This study reveals increased levels of reactive oxygen species, malondialdehyde, and carbonyl groups, indicating lipid and protein damage in the spinal cord of cows with chronic lameness. Mor… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

4
10
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 16 publications
(14 citation statements)
references
References 74 publications
4
10
0
Order By: Relevance
“…35 ROS levels in cows with chronic lameness can be found elevated significantly. 36 In our experiments, increased ROS levels were detected in the iPM (Figure 6).…”
Section: Ros Scavengers Acting On the Pm Can Effectively Relieve Cfa-...supporting
confidence: 59%
“…35 ROS levels in cows with chronic lameness can be found elevated significantly. 36 In our experiments, increased ROS levels were detected in the iPM (Figure 6).…”
Section: Ros Scavengers Acting On the Pm Can Effectively Relieve Cfa-...supporting
confidence: 59%
“…There is a rationale in inclusion of hormonal measurements, especially cortisol, in both experimental and clinical studies of pain response [ 37 , 38 ]. Estimation of cortisol levels remain a well proven and common tool for pain evaluation, and together with other physiological parameters, such as lipid profile and oxidative stress biomarkers, are strongly associated with the chronic pain [ 39 42 ]. Physiological markers have high sensitivity and specificity, and are regarded as indices of homeostatic changes that follow a painful event [ 43 ].…”
Section: Discussionmentioning
confidence: 99%
“…Personality also significantly impacted baseline oxidative status in strains of mice (Mus musculus) bred to exhibit different levels of aggression [47]. Additionally, Mike had chronic bouts of lameness, which is associated with oxidative stress in dairy cows [48]. Any of these factors could have interacted with Mike's social position or unique personality to render him more susceptible to oxidative stress under challenging conditions.…”
Section: Relationships Between Physiological and Behavioral Indicator...mentioning
confidence: 99%