Spinal Stenosis Caused by Calcinosis in a Patient With Systemic Sclerosis

Gazitt, Tal; Feld, Joy; Zisman, Devy

doi:10.3899/jrheum.201389

Cited by 3 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other common locations include the forearms, elbows, and extensor surface of the knees [14]. Unusual locations like the spine or face are reported in some studies [15][16][17][18]20]. Spinal calcinosis, which was found to occur commonly in association with acral calcinosis [21], can lead to radiculopathy, spinal stenosis, or cord compression [15][16][17][18]21,22].…”

Section: Location and Its Impactmentioning

confidence: 99%

Calcinosis in systemic sclerosis

Davuluri,

Lood,

Chung

2023

Current Opinion in Rheumatology

View full text Add to dashboard Cite

Purpose of review To provide updated information on the prevalence, pathogenesis, diagnostics, and therapeutics of calcinosis cutis associated with systemic sclerosis (SSc). Recent findings Observational studies show ethnic and geographical differences in the prevalence of calcinosis. In addition to clinical and serological associations, biochemical studies and in-vivo models have attempted to explain theories behind its pathogenesis, including prolonged state of inflammation, mechanical stress, hypoxia, and dysregulation in bone and phosphate metabolism. Long-term use of proton pump inhibitors may increase the risk for calcinosis in SSc. Few single center observational studies have shown mild benefit with minocycline and topical sodium thiosulfate. Summary Calcinosis cutis is the deposition of insoluble calcium in the skin and subcutaneous tissues. It affects up to 40% of SSc patients and causes significant morbidity. Long disease duration, features of vascular dysfunction, and osteoporosis have been associated with calcinosis. Altered levels of inorganic pyrophosphate and fibroblast growth factor-23 have been implicated in dysregulated phosphate metabolism that may lead to calcinosis in SSc. Plain radiography can help with diagnosis and quantifying the calcinosis burden. Surgical treatment remains the most effective therapy when feasible. At present, no medical therapies have proven efficacy in large randomized controlled trials.

show abstract

Section: Location and Its Impactmentioning

confidence: 99%

Calcinosis in systemic sclerosis

Davuluri,

Lood,

Chung

2023

Current Opinion in Rheumatology

View full text Add to dashboard Cite

show abstract

“…Unusual locations like the spine or face are reported in some studies [15][16][17][18][19]. Spinal calcinosis, which was found to occur commonly in association with acral calcinosis [20], can lead to radiculopathy, spinal stenosis or cord compression [15][16][17][18]21].…”

Section: Location and Its Impactmentioning

confidence: 99%

“…Other common locations include the forearms, elbows and extensor surface of the knees [14]. Unusual locations like the spine or face are reported in some studies [15][16][17][18][19]. Spinal calcinosis, which was found to occur commonly in association with acral calcinosis [20], can lead to radiculopathy, spinal stenosis or cord compression [15][16][17][18]21].…”

Section: Location and Its Impactmentioning

confidence: 99%

Calcinosis in systemic sclerosis

Davuluri

Lood

Chung

2022

Current Opinion in Rheumatology

View full text Add to dashboard Cite

Purpose of reviewThe aim of this study was to provide updated information on the prevalence, pathogenesis, diagnostics and therapeutics of calcinosis cutis associated with systemic sclerosis (SSc).Recent findingsObservational studies show ethnic and geographical differences in the prevalence of calcinosis. In addition to clinical and serological associations, biochemical studies and in-vivo models have attempted to explain theories behind its pathogenesis, including prolonged state of inflammation, mechanical stress, hypoxia and dysregulation in bone and phosphate metabolism. Long-term use of proton pump inhibitors may increase the risk for calcinosis in SSc. Few single-centre observational studies have shown mild benefit with minocycline and topical sodium thiosulfate.SummaryCalcinosis cutis is the deposition of insoluble calcium in the skin and subcutaneous tissues. It affects up to 40% of SSc patients and causes significant morbidity. Long disease duration, features of vascular dysfunction and osteoporosis have been associated with calcinosis. Altered levels of inorganic pyrophosphate and fibroblast growth factor-23 have been implicated in dysregulated phosphate metabolism that may lead to calcinosis in SSc. Plain radiography can help with diagnosis and quantifying the calcinosis burden. Surgical treatment remains the most effective therapy when feasible. At present, no medical therapies have proven efficacy in large randomized controlled trials.

show abstract