Spinal Sufentanil Effects on Spinal Pain-transmission Neurons in Cats

Aoki, Mamoru; Senami, Masaki; Kitahata, Luke M.; Collins, J. G.

doi:10.1097/00000542-198602000-00016

Cited by 11 publications

(3 citation statements)

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“…Sufentanil might act locally on the spinal cord or on the oxytocin-related neurones in the hypothalamus by rostral dispersion or by systemic absorption. 26 In the spinal cord, intrathecal sufentanil can inhibit the oxytocin release by a dual mechanism: One, compatible with our original hypothesis, consists of a selective and potent block of noxious input that activates neural circuitry pathways in the dorsal horns, a well-known action of intrathecal opioid, 27 which could lead to hypothalamic release of oxytocin (probably Ferguson's reflex). The other disrupts the effects of specific inputs that elicit the reflex spurt release of oxytocin, similar to suckling-induced oxytocin release pathway, as postulated by Wright.…”

Section: Discussionsupporting

confidence: 54%

Effects of intrathecal sufentanil on plasma oxytocin and cortisol concentrations in women during the first stage of labor

Stocche

Klamt²,

Antunes‐Rodrigues³

et al. 2001

Regional Anesthesia and Pain Medicine

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Section: Discussionsupporting

confidence: 54%

Effects of intrathecal sufentanil on plasma oxytocin and cortisol concentrations in women during the first stage of labor

Stocche

Klamt²,

Antunes‐Rodrigues³

et al. 2001

Regional Anesthesia and Pain Medicine

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“…Sufentanil was chosen for several reasons: it is the most potent opiate now clinically available. It has a very high lipid solubility and a high affinity for the mu opiate receptors (9,(20)(21)(22)(23)(24). Some reports have already shown the qualities of sufentanil in postoperative epidural analgesia (4-7).…”

Section: Discussionmentioning

confidence: 99%

“…Another drawback due to this hydrosolubility is the slow onset time of analgesia. It has been suggested that opiates with a high lipid solubility diminish the risk for respiratory depression (8, 20,23). Also, epidural opiates with high lipid solubility should promote rapid onset of action due to fast absorption and binding in the spinal cord with minimal residual cerebrospinal fluid concentrations that could be available for migration to the brain (9).…”

Section: Discussionmentioning

confidence: 99%

Epidural sufentanil for intra– and postoperative analgesia in thoracic surgery: a comparative study with intravenous sufentanil

Rosseel¹,

Broek²,

Boer³

et al. 1988

Acta Anaesthesiol Scand

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A comparative study was undertaken to evaluate the effectiveness of epidural sufentanil in providing intra- and postoperative analgesia during thoracic surgery. Sufentanil was chosen on the basis of its high lipid solubility and its potent opiate receptor binding. Epidural sufentanil was compared with intravenous sufentanil as the major intraoperative analgetic agent in an anesthesia regimen with midazolam and nitrous oxide. Epidural sufentanil significantly decreased the need for supplementary intravenous analgesia. In the epidural sufentanil group the immediate postoperative analgesia was found to be better, with a longer duration of action, compared with the intravenous sufentanil group. Postoperatively epidural sufentanil was compared with epidural morphine. Sufentanil provided good analgesia with a very fast onset and a mean duration of almost 7 h. Severe respiratory depression was observed in one patient within 1 h of extubation, probably due to the combined effects of the narcotic administration and residual midazolam. It is concluded that 50 micrograms of sufentanil administered in the thoracic epidural space provides valuable intraoperative analgesia which can easily be extended into the postoperative period, although all necessary precautions for epidural opiate administration should be taken.

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Pharmacotherapy of opioids: present and future developments

Meert

1996

Pharm World Sci

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The clinically available opioids have different physicochemical properties, resulting in differences in clinical profile with regard to potency, onset, and duration of activity. However, they all have comparable side-effects after acute systemic application. Several approaches can be used to overcome these side-effects. The following approaches, with special emphasis on the perioperative use of the opioids, are discussed: (1) the use of alternative routes of administration, such as via the spine (epidurally and intrathecally); (2) optimization of opioid delivery by means of slow-release preparations, chronic infusions with indwelling catheters, and transdermal delivery systems; (3) use of additional agents to potentiate the analgesic properties of the opioids so that the dose of opioid can be reduced; and (4) searching for new analgesics on the basis of knowledge of the pain-transmission system and the different opioid receptors with their functional interactions.

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Spinal Sufentanil Effects on Spinal Pain-transmission Neurons in Cats

Cited by 11 publications

References 0 publications

Effects of intrathecal sufentanil on plasma oxytocin and cortisol concentrations in women during the first stage of labor

Effects of intrathecal sufentanil on plasma oxytocin and cortisol concentrations in women during the first stage of labor

Epidural sufentanil for intra– and postoperative analgesia in thoracic surgery: a comparative study with intravenous sufentanil

Pharmacotherapy of opioids: present and future developments

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