Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors

Muñoz-Islas, Enriqueta; Lozano-Cuenca, Jair; González‐Hernández, Abimael; Ramírez‐Rosas, Martha B.; Sánchez-López, Araceli; Centurión, David; MaassenVanDenBrink, Antoinette; Villalón, Carlos M.

doi:10.1016/j.ejphar.2009.04.070

Cited by 22 publications

(20 citation statements)

References 29 publications

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“…Similarly, sumatriptan, via the activation of 5‐HT 1D , rather than 5‐HT 1B , receptors has been shown to reduce glutamate release onto SG neurons of the Vc (Jennings et al ., 2004). Although these previous studies suggest that 5‐HT 1B receptors are not involved in the anti‐migraine action of triptans in trigeminovascular sensory neurons, recent studies have suggested that a central trigeminal action of triptans, which is mediated by 5‐HT 1B rather than 5‐HT 1D receptors could be involved in the processing of craniovascular pain (Muñoz‐Islas et al ., 2006; 2009). Further studies are needed to verify whether 5‐HT 1B receptors can inhibit glutamate release from trigeminovascular afferents onto Vc neurons.…”

Section: Discussionmentioning

confidence: 99%

5‐HT_1B receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons

Cho

et al. 2012

British J Pharmacology

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Primary afferent-evoked EPSCs were recorded from medullary dorsal horn neurons of rat horizontal brain stem slices using a conventional whole-cell patch clamp technique under a voltage-clamp condition. KEY RESULTSCP93129, a selective 5-HT1B receptor agonist, reversibly and concentration-dependently decreased the amplitude of glutamatergic EPSCs and increased the paired-pulse ratio. In addition, CP93129 reduced the frequency of spontaneous miniature EPSCs without affecting the current amplitude. The CP93129-induced inhibition of EPSCs was significantly occluded by GR55562, a 5-HT1B/1D receptor antagonist, but not LY310762, a 5-HT1D receptor antagonist. Sumatriptan, an anti-migraine drug, also decreased EPSC amplitude, and this effect was partially blocked by either GR55562 or LY310762. On the other hand, primary afferent-evoked EPSCs were mediated by the Ca 2+ influx passing through both presynaptic N-type and P/Q-type Ca 2+ channels. The CP93129-induced inhibition of EPSCs was significantly occluded by w-conotoxin GVIA, an N-type Ca 2+ channel blocker. CONCLUSIONS AND IMPLICATIONSThe present results suggest that the activation of presynaptic 5-HT1B receptors reduces glutamate release from primary afferent terminals onto medullary dorsal horn neurons, and that 5-HT1B receptors could be, at the very least, a potential target for the treatment of pain from orofacial tissues. Abbreviations w-AgTx, w-agatoxin IVA; APV, DL-2-amino-5-phosphonovaleric acid; w-CgTx, w-conotoxin GVIA; CP93129, 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-diydropyrrolo[3,2-b]pyridine-5-one; GIRK, G-protein-coupled inwardly rectifying K LINKED ARTICLE

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Section: Discussionmentioning

confidence: 99%

5‐HT_1B receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons

Cho

et al. 2012

British J Pharmacology

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“…Binding assays show that 28 selectively binds to GABA A receptors containing the α 1 subunit, though the exact interactions are currently unknown 83 . 29 (donitriptan) is a 5-HT 1B agonist84 which entered phase II trials for the treatment of migraines 85…”

Section: Arylnitrile-containing Pharmaceuticalsmentioning

confidence: 99%

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

et al. 2010

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“…40) Similar results are shown in carotid artery in dogs. 41) Therefore, the direct vasoconstrictive effect of sumatriptan, and perhaps also the other triptan preparations, is mediated by 5-HT 1B receptors and not by 5-HT 1D receptors.…”

Section: Migrainementioning

confidence: 99%

5-Hydroxytryptamine Receptors as Targets for Drug Therapies of Vascular-Related Diseases

Gamoh

Hisa

Yamamoto

2013

Biological & Pharmaceutical Bulletin

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Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors

Cited by 22 publications

References 29 publications

5‐HT_1B receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons

5‐HT_1B receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

5-Hydroxytryptamine Receptors as Targets for Drug Therapies of Vascular-Related Diseases

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Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors

Cited by 22 publications

References 29 publications

5‐HT1B receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons

5‐HT1B receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

5-Hydroxytryptamine Receptors as Targets for Drug Therapies of Vascular-Related Diseases

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5‐HT_1B receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons

5‐HT_1B receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons