Spinal Tanycytic Ependymomas

Kawano, Nobuyuki; Utsuki, Satoshi; Suzuki, Ikurou; Kobayashi, Hiromasa; Saegusa, H; Oka, Hiroyuki; Fujii, Kiyotaka; Yagishita, Saburo

doi:10.1097/00005072-199905000-00134

Cited by 12 publications

(31 citation statements)

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“…2,4,6,8,10,11,13,14) Only six of the 22 cases of tanycytic ependymoma were thè`p ure type'' and all six arose in the spinal cord. 4,8,11) The six patients were four women and two men aged from 35 to 58 years (mean 46.8 years). The most common symptom was gradual deterioration of the motor function and/or sensory disturbance of the limbs.…”

Section: Discussionmentioning

confidence: 99%

“…The most common symptom was gradual deterioration of the motor function and/or sensory disturbance of the limbs. 4,8,11) There are only a few reports describing the MR imaging appearance of spinal tanycytic ependymomas. 8,10,11,14) The solid component of the tumor is usually enhanced after administration of contrast medium, and frequently associated with syrinx.…”

Section: Discussionmentioning

confidence: 99%

“…4,8,11) There are only a few reports describing the MR imaging appearance of spinal tanycytic ependymomas. 8,10,11,14) The solid component of the tumor is usually enhanced after administration of contrast medium, and frequently associated with syrinx. In the present case, the associated hematoma was thin and located in the center of the spinal cord (C2-4 levels) adjacent to the tumor, suggesting that the hematoma was situated in the syrinx or spinal cord parenchyma rather than in the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Both tanycytic ependymomas and astrocytomas usually show strong immunopositivity for GFAP, vimentin, and S-100 protein, whereas schwannomas are negative for GFAP and vimentin. [8][9][10][11] The ultrastructural findings, consisting of cilia, microvilli, and well-developed intermediate junctions, are strongly suggestive of an ependymal nature, which is essential for the diagnosis of tanycytic ependymoma. 8) The Ki-67/MIB-1 labeling index of previously reported tanycytic ependymomas ranged from 0% to 4.6%.…”

Section: Discussionmentioning

confidence: 99%

“…9) Histologically, tanycytic ependymomas are characterized by a stream and fascicular arrangement of the spindle cells. The absence of ependymal rosettes and inconspicuous perivascular pseudorosettes, especially in the``pure type'' of tanycytic ependymoma, 8) may cause diagnostic confusion with astrocytoma and even schwannoma.…”

Section: Introductionmentioning

confidence: 99%

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Spinal Tanycytic Ependymoma With Hematomyelia-Case Report-

Sato

Kubota

Ishida

et al. 2005

Neurol. Med. Chir.(Tokyo)

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A 58-year-old man presented with an extremely rare case of``pure type'' spinal tanycytic ependymoma associated with hematomyelia manifesting as sensory disturbance of the bilateral hands and weakness of the right arm. Magnetic resonance imaging demonstrated a tumor in the spinal cord from C-2 to C-4 levels. The soft gelatinous tumor was subtotally resected and the adjacent chronic liquid hematoma was aspirated. The immunohistochemical and ultrastructural findings indicated a diagnosis of tanycytic ependymoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Spinal Tanycytic Ependymoma With Hematomyelia-Case Report-

Sato

Kubota

Ishida

et al. 2005

Neurol. Med. Chir.(Tokyo)

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Supratentorial tanycytic ependymoma

Richards

Rosenfeld

Gonzales

et al. 2004

Journal of Clinical Neuroscience

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Highly anaplastic extraventricular ependymoma arising in an adult, mimicking metastatic adenocarcinoma with heavy stromal inflammation and emperiporesis

Moritani

Kushima²,

Bamba

et al. 2003

Pathology International

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We report a case of extraventricular ependymoma arising in a 50-year-old woman that took an aggressive clinical course with recurrence three times. The initial tumor was a well-circumscribed nodule in the right temporal white matter measuring 2 cm in diameter. It showed variegated histological findings mimicking metastatic adenocarcinoma: an epithelioid arrangement of highly pleomorphic cells with pseudopapillary structures and perivascular pseudorosettes, and bizarre multinucleated giant cells with occasional emperiporesis surrounded by abundant mononuclear inflammatory cells, as well as a focal small area of conventional ependymoma. Emperiporesis and abundant mononuclear cell infiltration were not previously described in an ependymoma. The recurrent tumors predominantly showed an epithelioid pattern with frequent formation of astroblastoma-like pseudopapillary structures. Neoplastic cells were markedly atypical and had characteristic intracytoplasmic eosinophilic inclusion bodies. Much of the cells in both the initial and recurrent tumors showed a positive immunostaining for glial fibrillary acidic protein (GFAP) with accentuation to the cytoplasmic processes of the pseudorosettes and pseudopapillary structures. Epithelial membrane antigen (EMA) highlighted the epithelial differentiation of the tumor cells, while cytokeratin was completely negative. Although this tumor might be classified to at least WHO grade III from the histology and aggressive behavior, the exact grading is still controversial because of the rarity of such cases.

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Spinal Tanycytic Ependymomas

Cited by 12 publications

References 0 publications

Spinal Tanycytic Ependymoma With Hematomyelia-Case Report-

Spinal Tanycytic Ependymoma With Hematomyelia-Case Report-

Supratentorial tanycytic ependymoma

Highly anaplastic extraventricular ependymoma arising in an adult, mimicking metastatic adenocarcinoma with heavy stromal inflammation and emperiporesis

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