Spinal Tuberculosis

Heyde, Christoph E.; Lübbert, Christoph; Wendt, Sebastian; Rodloff, Arne C.; Völker, Anna; von, Nicolas H.der Höh

doi:10.1055/a-1285-4994

Cited by 11 publications

(14 citation statements)

References 30 publications

(309 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8,910 The majority of cases occur in population-dense developing countries like Africa or India, however due to globalization and travelling it is no longer a disease limited to developing nations. 6,11 Most cases in the western world of spinal tuberculosis are seen primarily in immigrants form endemic countries. While in endemic countries, Pott´s disease is more common in children and younger adults, in developed Western and Middle East countries adults are affected.…”

Section: Introductionmentioning

confidence: 99%

“…While in endemic countries, Pott´s disease is more common in children and younger adults, in developed Western and Middle East countries adults are affected. 6,11,12 The upper lumbar and lower thoracic region of vertebral column is most frequently affected. Characteristically for spinal tuberculosis is destruction of the intervertebral disk space and the adjacent vertebral bodies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surgical management and clinical outcome of cervical, thoracic and thoracolumbar spinal tuberculosis in a mideuropean adult population

Kılınç

Setzer

Behmanesh

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective Spinal tuberculosis, known as Pott´s disease, is a rare but serious clinical condition which can lead to severe deformity and neurological complications. The majority of cases occur in population-dense developing countries like Africa or India, but due to globalization it is no longer a disease limited to developing nations. Thus it should be considered in patients with persistent back pain, who are at high risk, such as migrant population and immunocompromised patients. Nevertheless spinal tuberculosis remains in Germany a rarity and still a difficult diagnosis. Here we analyzed patients with Pott´s disease treated at our neurosurgical department supplying medical care for a mideuropean metropolitan region. Methods Patients with cervical, thoracic and thoracolumbar spinal tuberculosis between 2014 and 2022 were retrospectively analyzed. According to the infected anatomic segment, patients were assigned in one of three groups. All patients were evaluated clinically using the visual analog scale (VAS). American Spinal Injury Association (ASIA) impairment scale was used for assessment of neurological status. Surgery was performed when neurological deficit due to mechanical compression, deformity, instability, severe pain, necrotic bone or failure to respond to anti-tuberculous treatment were observed. Long term follow-up as well as complications related to surgery were recorded and analyzed. Results We identified 34 patients with spinal tuberculosis who underwent surgical treatment. All included patients had an immigrat background. In the cervical spinal tuberculosis group, there were 15 cases (46.9 %) with a mean age of 31.6+/-12 years. In 13 cases (86.7%) treatment consisted of spinal instrumentation. For two patient surgical debridement of the infected vertebrae and disc material and fusion was performed. In the thoracic spinal tuberculosis group, there were 10 cases (29.4%) with a mean age of 37.7+/-16 years. The treatment was performed by dorsolateral spinal instrumentation. In the thoracolumbar spinal tuberculosis group, there were 9 cases (26.4%) with a mean age of 44.1 +/-21 years. In five cases dorsolateral spinal instrumentation and in three cases only dorsal instrumentation was performed. The mean follow-up time was 47 months (range 6-96 months). All included patients demonstrated clinical healing of tuberculosis infection. Bony fusion was achieved in 94.1 % with no loosening or breakage of internal fixation. In all three groups, the VAS pain score at 8 weeks after operation and at the most recent follow-up were lower than the preoperative level. One patient in the first group and one patient in the third group relapsed after operation. A second surgery was necessary. In eight cases (23.5%) neurological impairment (ASIA D) and in one case (2.9%) ASIA C was described, which regressed completely (ASIA E). Conclusion Our results highlight the role of early surgery in the management of spinal tuberculosis. Patients with chronic back pain, immigration background and/or neurological deficit spinal TB should be considered as a differential diagnosis. Aggressive diagnosis of spinal TB is necessary and combined surgical intervention and medical treatment is associated with a favorable outcome.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surgical management and clinical outcome of cervical, thoracic and thoracolumbar spinal tuberculosis in a mideuropean adult population

Kılınç

Setzer

Behmanesh

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The majority of cases occur in population-dense developing countries like Africa or India, however due to globalization and travelling it is no longer a disease limited to developing nations 4 , 10 . Most cases in the western world of spinal tuberculosis are seen primarily in immigrants form endemic countries.…”

Section: Introductionmentioning

confidence: 99%

“…Most cases in the western world of spinal tuberculosis are seen primarily in immigrants form endemic countries. While in endemic countries, Pott´s disease is more common in children and younger adults, in developed Western and Middle East countries adults are affected 4 , 10 , 11 . The upper lumbar and lower thoracic region of vertebral column is most frequently affected.…”

Section: Introductionmentioning

confidence: 99%

Surgical management and clinical outcome of cervical, thoracic and thoracolumbar spinal tuberculosis in a middle-European adult population

Kılınç

Setzer

Behmanesh

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Spinal tuberculosis is due to globalization no longer a disease limited to developing nations. It remains in Germany a rarity and still a difficult diagnosis. Here we analyzed patients with spinal tuberculosis treated at our neurosurgical department. According to the infected anatomic segment, patients were assigned in one of three groups. Surgery was performed when neurological deficit due to mechanical compression, deformity, instability, severe pain, necrotic bone or failure to respond to anti-tuberculous treatment were observed. We identified 34 patients with spinal tuberculosis who underwent surgical treatment. In the cervical spinal tuberculosis group, there were 15 cases (46.9%) In most cases treatment consisted of spinal instrumentation. In the thoracic group, 10 cases (29.4%) were observed. The treatment was performed by dorsolateral spinal instrumentation. For the thoracolumbar group, 9 cases (26.4%) were observed. In most cases dorsolateral spinal instrumentation was performed. One patient in the first group and one patient in the third group relapsed after operation. A second surgery was necessary. Patients with chronic back pain, immigration background and/or neurological deficit spinal TB should be considered as a differential diagnosis. Combined surgical intervention and medical treatment is associated with a favorable outcome.

show abstract

“…Because of its increase in annual incidence, it has become a challenge in developing countries [ 1 , 2 ]. Spinal tuberculosis is the most common manifestation of extrapulmonary tuberculosis [ 3 ], the symptoms of which include pain, fatigue, fever, night sweats, weight loss, and other symptoms of tuberculosis poisoning [ 4 ]. Its clinical treatment generally adopts two measures, antituberculosis treatment and surgery [ 5 , 6 ].…”

mentioning

confidence: 99%

Predicting Surgical Site Infection Risk after Spinal Tuberculosis Surgery: Development and Validation of a Nomogram

Chen

Liu

et al. 2022

Surgical Infections

View full text Add to dashboard Cite

Background: The purpose of this study was to predict the surgical site infection risk after spinal tuberculosis surgery based on a nomogram. Patients and Methods: We collected the clinical data of patients who underwent spinal tuberculosis surgery in our hospital and included all the data in the least absolute shrinkage and selection operator (LASSO) regression analysis. Next, the selected parameters were analyzed using logistic regression. The logistic regression analysis and receiver operating characteristic (ROC) curve analysis were further used to obtain statistically significant parameters. These parameters were then used to construct a nomogram. The C-index, ROC curve, and decision curve analysis (DCA) were used to assess the predictive ability and accuracy of the nomogram, whereas internal verification was used to calculate the C-index by bootstrapping with 1,000 resamples. Results: A total of 394 patients with spinal tuberculosis surgery were included in the study, of whom 76 patients had surgical site infections whereas 318 patients did not. The predicted risk of surgical site infection in the nomogram ranged between 0.01 and 0.98. Both the value of the C-index of the nomogram (95% confidence interval [CI], 0.62–0.76) and the area under the curve (AUC) were found to be 0.69. The net benefit of the model ranged between 0.01 and 0.99. In contrast, the C-index calculated by the internal verification method of the nomogram was found to be 0.68. Conclusions: The risk factors predicting surgical site infection after spinal tuberculosis surgery included albumin, lesion segment, operation time, and incision length.

show abstract

Spinal Tuberculosis

Cited by 11 publications

References 30 publications

Surgical management and clinical outcome of cervical, thoracic and thoracolumbar spinal tuberculosis in a mideuropean adult population

Surgical management and clinical outcome of cervical, thoracic and thoracolumbar spinal tuberculosis in a mideuropean adult population

Surgical management and clinical outcome of cervical, thoracic and thoracolumbar spinal tuberculosis in a middle-European adult population

Predicting Surgical Site Infection Risk after Spinal Tuberculosis Surgery: Development and Validation of a Nomogram

Contact Info

Product

Resources

About