Spinal vasopressin alleviates formalin-induced nociception by enhancing GABAA receptor function in mice

The role of peripheral vasopressin 1A and oxytocin receptors on the subcutaneous vasopressin antinociceptive effects

“…AVP (Peng et al., ) and OT produce central (Condés‐Lara et al., ; DeLaTorre et al., ) and peripheral (Hobo et al., ; Qiu et al., ) antinociception; however, the receptor involved in those effects is still a matter of debate (González‐Hernández et al., ). In this regard, administration of AVP or OT in V 1A R knockout mice failed to evoke behavioural analgesia (Schorscher‐Petcu et al., ; Mogil et al., ; Qiu et al., ).…”

“…AVP has multiple antinociceptive actions in the central nervous system. Microinjection of AVP in the nucleus raphe magnus (Yang et al., ), caudate nucleus (Yang et al., ) and spinal cord (Peng et al., ) produces antinociception. The participation of opiate and serotonin systems in AVP central antinociception has also been reported (Yang et al., ).…”

“…Arginine‐vasopressin (AVP), a neurohypophysial hormone well known for its effects on water homeostasis and blood pressure regulation, has been implied as a potential peptide modulating nociception. In rodents, intracerebroventricular (Kordower and Bodnar, ) and intrathecal (Thurston et al., , ; Peng et al., ) AVP administration produces behavioural analgesia. Furthermore, a physiological antinociceptive participation of AVP has been suggested by the facts that the AVP‐deficient Brattleboro rat strain has hyperalgesia and diminished stress‐induced analgesia (Bodnar et al., ), and that the systemic hyperosmotic challenge, a model of physiological release of AVP, produces antinociception (Schorscher‐Petcu et al., ).…”

Arginine vasopressin: Direct and indirect action on metabolism

“…In the mammalian brain, AVP is predominantly synthesized in the hypothalamus; magnocellular vasopressinergic neurons of the PVN, supraoptic nucleus (SON), parvocellular vasopressinergic neurons of the PVN, and accessory nuclei located between the SON and PVN [ 24 ]. In the PVN, AVP is produced in parvocellular neurons projecting to the median eminence, brainstem autonomic nuclei, and spinal cord [ 25 , 26 ]. In the SCN, AVP is produced in the shell, which is the dorsomedial part of the SCN [ 27 ].…”

<p>DNA Microarray Analysis of Differential Gene Expression in the Dorsal Root Ganglia of Four Different Neuropathic Pain Mouse Models</p>

“…Arginine vasopressin (AVP) is a seven-transmembrane domain G-coupled polypeptide that has been demonstrated to play roles in many neurological functions, such as autism, 9 sex behavior, 10 schizophrenia, 11 aggression, and pain. Intracerebroventricular 12 and intrathecal 13 administration of AVP produces behavioral analgesia in rodent models. A canonical animal study 14 demonstrated that AVP-deficient Brattleboro rats have hyperalgesia and diminished stress-induced analgesia.…”