Spindle Cell Carcinoma of the Breast: A Case Report Representing Diagnostics, Therapeutics, Intervention, and Outcome

Abstract

Background: Spindle cell carcinoma (SpCC) is an unusual form of squamous cell carcinoma (SCC) and can sometimes present in the breast. Owing to the rarity of breast SpCC, few case studies are available nowadays and proper evidence is scarce. Case presentation: We herein report a 60-year-old female patient, who was referred to the surgery services after presenting with a right breast ulcerated mass. On physical examination, a 7x7 cm mass was found along with a 3 cm ulcer on the top of it. Both mammography and ultrasound showed a dense mass, and tru-cut and skin punch biopsies confirmed neoplastic spindle cells within the lesion. The patient underwent a right total mastectomy with sentinel lymph node biopsies with no further chemotherapy or radiotherapy. Conclusion: Owing to the heterogeneity of SpCC, there is no exact treatment protocol for this type of cancer, and mastectomy or conservative surgery can be performed in certain groups of patients depending on tumor size, stage, and lymph node involvement. Fortunately, promising medical and biological therapies might be of use in the near future.

Spindle cell carcinoma of the breast: a case study report from Mankweng hospital & literature review

“…The diagnostic approach for spindle cell carcinoma is not different from other breast lesions. Mammogram is the first choice of imaging and Mammogram findings frequently show BI-RADS 4/5 with no calcifications [7]. In our case, the mammogram described left breast enlargement as dense, and there were no calcifications noted.…”

“…It usually presents during the postmenopausal period, unlike other breast lesions, which might present earlier [6]. The average age of diagnosis of Spindle cell carcinoma of the breast is 54 years [7]. Our patient was a 58-year-old female who presented at an advanced stage despite a growing rapidly breast mass.…”