Spindle Cell Carcinoma of the Larynx: A Confusing Diagnosis for the Pathologist and Clinician

Bostancı, Aslı; Özbilim, Gülay; Turhan, Murat

doi:10.1155/2015/831835

Cited by 9 publications

(3 citation statements)

References 11 publications

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“…4 It was first reported in the literature in 1933 by Figi, as 'larynx sarcoma'. 5 The oral cavity is the next most frequent site after the larynx, with the tumor affecting the lower lips, tongue and buccal mucosa. 6 The majority (>95%) of laryngeal carcinomas are squamous cell carcinomas (SCCs).…”

Section: Discussionmentioning

confidence: 99%

Spindle cell carcinoma of the larynx: a rare entity

Ramakrishnan,

Natarajan,

Kamath

et al. 2023

Int J Otorhinolaryngol Head Neck Surg

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Squamous cell carcinoma (SCC) is the commonest malignancy encountered in the larynx in the Indian population. Spindle cell carcinoma is an extremely rare malignant tumor and is a variant of SCC with a mesenchymal like malignant cell component. This is a case report of a 58 years old patient who presented with hoarseness of voice of 7 months duration. He was diagnosed to have a right vocal cord polypoidal growth with mobile vocal cords. He underwent direct laryngoscopy and biopsy of the lesion which was reported as spindle cell neoplasm/inflammatory myofibroblastic tumor (IMT). Immunohistochemistry (IHC) was carried out and confirmed the diagnosis of inflammatory myofibroblastic tumor. He was doing well and the follow up videolaryngoscopic examinations and PET CT were normal. At subsequent follow-up 19 months later, he was found to have a recurrent right vocal cord lesion. Direct laryngoscopy and biopsy was repeated along with laserization of the right vocal cord. Histopathology was reported as spindle cell malignant neoplasm. Immunohistochemistry was reported as spindle cell carcinoma. He was then sent for radiation therapy. The patient responded well to radiation and is tumor free at last follow-up. He has been advised regular follow-ups. Spindle cell carcinoma is an extremely rare laryngeal malignancy. It typically originates in the glottis. The treatment for spindle cell carcinoma includes surgery, radiation or a combination of these modalities. Its prognosis is worse than squamous cell carcinoma and patients require close follow-ups.

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Section: Discussionmentioning

confidence: 99%

Spindle cell carcinoma of the larynx: a rare entity

Ramakrishnan,

Natarajan,

Kamath

et al. 2023

Int J Otorhinolaryngol Head Neck Surg

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“…3 Sarcomatoid squamous cell carcinoma is the most commonly noted at the level of the glottis. 4 It is a biphasic tumor due to its epithelial and mesenchymal components. 5 Here, we present a patient diagnosed with sarcomatoid squamous cell carcinoma of the right vocal cord in the early stage and was treated successfully.…”

Section: Introductionmentioning

confidence: 99%

Sarcomatoid Squamous Cell Carcinoma of Vocal Cord: An Uncommon Malignancy

Prasad

Bhat

Aroor

et al. 2023

Journal of Health and Allied Sciences NU

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Sarcomatoid squamous cell carcinoma is a rare variant of laryngeal carcinoma, which comprises 1.3% of all laryngeal malignancies. It is mainly seen in elderly individuals, with smoking and alcohol being common risk factors. The tumor is most common on true vocal cords; hence, patients especially present with dysphonia. We present a case of an elderly male patient who presented with dysphonia due to a vocal cord lesion. During microlaryngoscopy, a firm, exophytic lesion with a narrow stalk was attached to the anterior one-third of the right vocal cord, excised, and sent for histopathology. Histopathology was suggestive of sarcomatoid squamous cell carcinoma. The patient was successfully treated with radiotherapy. We conclude that benign-appearing laryngeal lesions need to be evaluated and histopathological examination to be performed so that rare entities such as sarcomatoid carcinoma, which mimics benign lesions, can be managed appropriately.

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“…The most frequent symptoms at the presentation are dysphonia, hoarseness and rarely dyspnea, when arising in subglottic site. Macroscopically, the majority of cases appear as exophytic and polypoid mass arising from one of the true vocal folds or from anterior commissure [ 7 ]. Due to its rarity, there is currently no generally acceptable treatment guideline for this disease.…”

Section: Introductionmentioning

confidence: 99%

Carcinosarcomas of the larynx: systematic review of the literature of a rare nosologic entity

Colizza

Gilardi

Greco

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose Carcinosarcoma, also known as Spindle Cell Carcinoma (SpCC), is a rare type of malignant tumor. Generally, this type of pathology occurs in the urogenital tract, the gastrointestinal tract, respiratory tract and mammary gland; in the larynx, SpCC represents only 2–3% of all malignancies. Due to its rarity, there is currently no generally acceptable treatment guideline for this disease. The aim of this study was to systematically review the literature of SpCC of larynx and report epidemiologic, clinicopathologic and main therapeutic approaches for this entity. Methods A systematic literature review was performed using MEDLINE, EMBASE, PubMed and Scopus databases. For this review, the results were extrapolated in the period between January 1990 to September 2020. Data extraction was performed using a standard registry database. The clinical and pathological staging were recalculated according to the Eight Edition of AJCC Cancer Staging Manual and statistical analyses were performed using SPSS Version 25.0. Results A total of 111 patients affected by laryngeal carcinosarcoma were included. From our review arises that surgery is the main treatment for primary laryngeal carcinosarcoma. In this way, various techniques such as minimally invasive laryngoscopy excision, laser CO2 cordectomy, partial laryngectomy (vertical and horizontal) and total laryngectomy. The role of radiotherapy is still controversial. The overall survival (OS) for T1 stage tumor at 5 years of follow-up is 82.9%, the OS for T2 and T3 tumor is 74% and 73.4%. The OS at 5 years of follow-up is 91.7% for supraglottic tumor, 69.3% for glottic tumor and 50% for transglottic site. Subglottic site is described in only 2 cases [12–13], so the OS at 5 years is not statistically significant. The 5-year overall survival in patients without lymph nodes involvement (N0) is 90.2%, 66.7% and 50%, respectively, for N1 and N2 lesions. Conclusion Primary laryngeal carcinosarcoma is a very rare malignancy. There are no clear guidelines in the management but in the literature, surgery is described as the best modality of therapy; radiation only can be a reasonable alternative with controversial efficacy. The most important prognostic factor is the nodal metastasis.

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Spindle Cell Carcinoma of the Larynx: A Confusing Diagnosis for the Pathologist and Clinician

Cited by 9 publications

References 11 publications

Spindle cell carcinoma of the larynx: a rare entity

Spindle cell carcinoma of the larynx: a rare entity

Sarcomatoid Squamous Cell Carcinoma of Vocal Cord: An Uncommon Malignancy

Carcinosarcomas of the larynx: systematic review of the literature of a rare nosologic entity

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