Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

Abstract

BackgroundOwing to the rarity, the general demographics, basic clinico-pathologic features, management, outcome and prognostic factors of spindle cell carcinoma (SpCC) were unexplored.MethodsA SEER analysis was performed with 2336 cases (1973-2016).ResultsA peak incidence occurred at 70~80 years without any gender predominance and 83.13% occurred in white people. The respiratory system was mostly affected tumor site (35%). Significant overall survival (OS) and disease specific survival (DSS) were found differentiated in gender, age, marital status, primary tumor location, AJCC stage, T stage, N stage, M stage, pathologic grade and treatment modality. In the multivariate Cox model, the age > 69 years (Hazard ratio [HR] = 1.427 for OS, P = 0.01 and HR = 1.491 for DSS, P = 0.003; Reference [Ref] age ≤ 69 years), tumor location in respiratory system (HR = 1.550 for OS, P = 0.041 and HR = 1.561 for DSS, P = 0.04; Ref: digestive system), N2 stage (HR = 1.962 for OS, P = 0.006 and HR = 1.982 for DSS, P = 0.004; Ref: N0 stage) and AJCC stage IV (HR = 4.601 for OS, P = 0.000 and HR = 5.107 for DSS, P = 0.000; Ref: stage I) were independently associated with worse OS and DSS.ConclusionsSpCC mostly occurred in white people at 70~80 years old without predominance in any gender. The respiratory system was mostly affected site. The patient's age, primary tumor location, AJCC stage were independent prognostic indicators for both DSS and OS of SpCC.

Long-term survival in a patient with pulmonary spindle cell carcinoma treated with traditional Chinese medicine

“… 1 There is no standard treatment for SCC, though the conventional therapies including surgery, chemotherapy and radiotherapy are commonly used. 2 Previous case reports showed poor prognosis and rapid progression of SCC. 2–4 In inoperable cases, platinum-based chemotherapy was selected according to non-small cell carcinoma regimens.…”

“… 2 Previous case reports showed poor prognosis and rapid progression of SCC. 2–4 In inoperable cases, platinum-based chemotherapy was selected according to non-small cell carcinoma regimens. Only 3 of 12 patients had a survival of more than 11 months.…”

Second Primary Spindle Cell Carcinoma of Oral Cavity and Oropharynx: A Case Report and Literature Review

“…Some risk factors have been reported with SpCC, including male gender, advanced age (over 70 years old), and tobacco and alcohol exposure [5,6]. Prognosis of SpCC has been related to age, tumor location, depth of invasion, growth pattern, history of radiotherapy, vascular invasion, and AJCC tumor staging [1,7,8].…”

“…Reported risk factors include male gender, advanced age, and tobacco and alcohol exposure [5,6]. Prognosis of SpCC has been related to age, tumor location, depth of invasion, growth pattern, history of radiotherapy, vascular invasion, and American Joint Committee on Cancer (AJCC) tumor staging [1,7,8]. Among patients with recurrent head and neck carcinomas, 80% to 90% of patients develop recurrence within three years [9].…”

Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report

“…Clinically similar to conventional SCC, SpSCC presents as an ulcerated or exophytic mass. It is more often seen in older Caucasians and is usually confined to sun-damaged sites, such as the head and neck area, or areas that have received prior ionizing radiation [2][3][4][5].…”