Spindle cell haemangioma of the tongue

Abstract

Although SCH rarely presents in the oral cavity it needs to be considered in the differential diagnosis of oral cavity tumors.

Spindle Cell Hemangioma in the Mucosa of the Upper Lip: A Case Report and Review of the Literature

“…However, in the present case, WT-1 was focally positive at both endothelial cells in cavernous areas and spindle cells in solid areas. Although Wang et al suggested that SCH is primarily a lymphatic malformation, we consider that SCH is a vascular lesion arising from a vascular malformation, composed of mixed cells, such as vascular and lymphatic cells from the immunochemical result of all the markers performed in this case and other literatures [ 1 , 5 , 7 , 9 , 11 , 15 , 17 , 19 ].…”

“…Immunohistochemically, the cells lining the cavernous space and vacuolated epithelioid cells are positive for vimentin, CD31, CD34, and factor-VIII-related antigen, supporting the endothelial nature [ 1 – 3 , 5 , 7 – 9 , 11 , 12 , 15 ]. Weiss and Enzinger [ 13 ], Tosios et al [ 1 ], Ide et al [ 5 ], and Cai et al [ 9 ] reported that the lining cells and vacuolated epithelioid cells are positive for vimentin, CD31, CD34, and factor VIII, and in contrast, spindle cells are negative for endothelial markers.…”

“…In the majority of cases, the symptoms were not remarkable [ 18 ]. Most SCH lesions were fewer than 2 cm in size [ 3 , 5 , 7 , 9 , 11 ]. Only four cases in the head and neck region were more than 30 mm, including the present case, which was the only case of the oral lesion more than 30 mm.…”

“…The endothelial cells often have focal epithelioid features and show focal cytoplasmic vacuolization. Mitotic activity and atypia are low [ 11 , 13 ].…”

Modern classification of hemangiomas

“…(2014) вважають, що веретеноклітинна гемангіома первинно є лімфатичною мальформацією [61], а P. Perkins і W. Sharon (1996) -що це доброякісна або реактивна пухлина [48]. Але більшість дослідників дотримуються думки, що ця гемангіома має судинне походження із залученням як судинних, так і лімфатичних клітин [7,20,40]. Веретиноклітинній гемангіомі притаманна наявність наступних гістологічних ознак: значно дилатовані судинні простори, суцільні зони веретеноподібних клітин та роздуті, округлі або полігональні епітеліальні клітини з прозорою, часто вакуолізованою, цитоплазмою [37].…”