Spindle cell hemangioendothelioma of the spinal cord

Abstract

An intradural extramedullary spinal cord hemangioendothelioma at T10, T11 recurred twice and was irradiated after the third resection. This first reported case prompted a review of the neuropathology and natural history of this unusual tumor.

Intramedullary Spindle Cell Hemangioendothelioma of the Thoracic Spinal Cord

“…14) Intradural extramedullary spindle cell hemangioendothelioma involving the thoracic spinal cord recurred twice despite the benign histology and was irradiated after the third excision. 15) Immunohistochemical staining to identify cell proliferation markers, such as MIB-1 for Ki-67 antigen, as indicators of malignant behavior are useful in tumors of the central nervous system, particularly astrocytomas, but the implication…”

“…Intradural extramedullary spindle cell hemangioendothelioma involving the thoracic spinal cord was treated by local radiotherapy using a limited field. 15) A tumor dose of 50 Gy in 28 fractions was given. The patient remained well with no evidence of recurrent tumor about 2 years after radiotherapy with good local control.…”

“…However, the recommended radiation dose ranges from 20 to 50 Gy. 4,15) Our patient was treated with radiotherapy because of the significant residual tumor, high vascularity, and general unpredictable behavior of hemangioendothelioma. The patient demonstrated good neurological recovery following radiotherapy and is still doing well at present.…”

“…9,16,24,27,31,33,34) However, intracranial or intraspinal involvement are infrequent. 2,6,12,13,15,29,30) We describe a case of intraspinal and intramedullary spindle cell hemangioendothelioma.…”

Spindle Cell Hemangioma Reoccurrence in the Hand: Case Report

“…They most often have an indolent coarse [9,13], but can become painful and disfiguring [8,17]. Most lesions occur in the dermis and subcutaneous tissues, but have been found in the viscera, spinal cord, cervix, and oral cavity [26,36,40,41,43].…”