Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report

Abstract

Spindle cell hemangioma is a benign vascular tumor typically occurring in the dermis or subcutis of distal extremities as red–brown lesions that can grow in both size and number over time. They can be very painful and potentially disabling. A family history of cancer or previous history may be relevant and must be taken into consideration. Juxtaglomerular cell tumor (reninoma) is an extremely rare cause of secondary hypertension diagnosed mostly among adolescents and young adults. Excessive renin secretion results in secondary hyperaldosteronism. Subsequent hypokalemia and metabolic alkalosis, together with high blood pressure, are clues for clinical diagnosis. Histological examination of the excised tumor leads to a definitive diagnosis. Reninoma is found in subcapsular localization, in most cases as a solitary mass, in imaging studies of kidneys. Exceptionally, it can be located in another part of a kidney. Both spindle cell hemangioma and reninoma are extremely rare tumors in children and adolescents. Herein, the authors present a case report of a patient with hereditary BRCA1 interacting protein C-terminal helicase 1 (BRIP1) mutation, spindle cell hemangioma, and secondary hypertension caused by atypically localized reninoma.

Spindle cell hemangioma of the lung: An unusual presentation

“…Rare cases presenting in non‐cutaneous regions have also been described, including, mediastinum, pleura, spinal cord, muscles, thyroid, spleen, retroperitoneum and even infratemporal fossa. 1 , 6 , 7 , 8 , 9 , 10 , 11 …”

“…6 Rare cases presenting in non-cutaneous regions have also been described, including, mediastinum, pleura, spinal cord, muscles, thyroid, spleen, retroperitoneum and even infratemporal fossa. 1,[6][7][8][9][10][11] So far only two cases of pulmonary SCH were reported in the literature. 2,12 The first case was reported in 2019, where SHC presented as multiple round nodules with smooth borders and uniform density in both lungs, and the diagnosis was made by video-assisted thoracoscopic biopsy of the largest and most accessible lesion.…”