Spindle cell lipoma

Abstract

Spindle cell lipoma is a specific type of lipoma that is easily mistaken for a liposarcoma. An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals that is occurs chiefly in male patients between 45 and 70 years of age and affects the regions of the shoulder and posterior neck almost exclusively. Microscopically, it consists of an intricate mixture of lipocytes and uniform spindle cells within a matrix of mucinous material traversed by a varying number of birefringent collagen fibers. Ultrastructural studies in one case support the fibroblastic nature of the spindle cells. Followup information obtained in 63 patients with this lesion revealed a uniformly favorable clinical course, indicating that local excision is the treatment of choice, and that there is no need or reason for radical surgical procedures.

Distinct cytologic features of spindle cell lipoma

“…In previous reports, it was believed that these cells arose from an early lipoblast lineage. 7,8 In EM examination of the tumors from our patients, spindle cells showed some features of fibroblasts, although some of these cells contained nonmembrane-bound lipid droplets, suggesting a prelipoblastic nature of spindle cells.…”

“…The clinical and histologic features of SCL have been described previously. [7][8][9][10] There are also a few reports that included electron microscopic and cytogenetic findings of SCL. 8,[11][12][13] The cytologic features of SCL, however, are poorly defined, with only three patients described in the literature.…”

Well-differentiated spindle cell liposarcoma (‘atypical spindle cell lipomatous tumor‘) does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases

“…7 Spindle cell lipoma has been first described by Enzinger in 1975 and arises predominantly as an encapsulated subcutaneous neoplasm in the neck, shoulder, or upper back of elderly male patients. 8 However, superficially located, purely dermal cases show a wider anatomic distribution and affect female patients more frequently. 9 Spindle cell lipoma is composed of mature lipogenic cells associated with a varying number of bland, CD34 positive spindled cells that are set in a collagenous stroma with characteristic ropy-like collagen bundles, and often associated mast cells are seen.…”

Spindle Cell Lipoma of The Spermatic Cord Accompanying Pheochromacytoma

“…It is mostly located at back and shoulders. It is mostly seen in man over 40 years (1). Besides its common localizations SCL was reported to locate in rare localizations like retsius cavity, breast and mouth (2)(3)(4).…”