Spindle cell nevi and epithelioid cell nevi (so-called juvenile melanomas) in children and adults.A clinicopathological study of 27 cases

Kernen, Jules A.; Ackerman, Lauren V.

doi:10.1002/1097-0142(196005/06)13:3<612::aid-cncr2820130324>3.0.co;2-g

Cited by 140 publications

(40 citation statements)

References 21 publications

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“…According to some authors, it is found in 80% -90% of the lesions, which is consistent with our findings (78 and 81%). (6.12) In our study, all (100%) nevi were symmetric and showed full dermal maturation like other studies except for Kernen and Ackerman study (12) who reported that dermal maturation was mostly absent.…”

Section: Discussionsupporting

confidence: 82%

Clinical and Histopathology Features of Spitz Nevus: In 22 Cases

Rahbar¹,

Ghannadan²,

Kamyab³

2016

Razavi Int J Med

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Section: Discussionsupporting

confidence: 82%

Clinical and Histopathology Features of Spitz Nevus: In 22 Cases

Rahbar¹,

Ghannadan²,

Kamyab³

2016

Razavi Int J Med

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“…14 Since the delineation of the Spitz nevus as a distinct entity (in fact, the lesion was originally aptly termed ''juvenile melanoma'' by Sophie Spitz herself), the biological nature of these lesions has been the subject of unprecedented discussion, debate, controversy, and investigation for a half century. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] It is now well established (but not without controversy) that a subgroup of Spitz tumors often intermediate between prototypic Spitz nevi and melanoma exist. The latter group of lesions commonly termed ''atypical,'' indeterminate, or ambiguous Spitz tumors may be impossible to distinguish microscopically from melanoma and/or to predict their biological behavior.…”

Section: Introductionmentioning

confidence: 99%

Atypical Spitzoid Melanocytic Neoplasms With Angiotropism: A Potential Mechanism of Locoregional Involvement

Barnhill¹,

Kutzner²,

Schmidt³

et al. 2011

The American Journal of Dermatopathology

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Atypical spitzoid melanocytic neoplasms (ASMN) may prove difficult to distinguish microscopically from melanoma, and their biological behavior may be unpredictable. ASMN may result in regional lymph node (LN) metastases and frequent sentinel lymph node (SLN) deposits. Angiotropism and extravascular migratory metastasis may account for locoregional metastases in melanoma and thus may potentially explain such locoregional involvement in ASMN. Nine ASMN with angiotropism from 2006 to 2010 were studied. Angiotropism was defined as melanocytes closely opposed to the external surfaces of microvascular channels without intravasation. There were 5 women and 4 men aged 6-40 (mean 18.7) years with ASMN involving the head and neck (5), the extremities (3), and the trunk (1), and the lesions ranged in diameters from 3.5 to 10 (mean 6.2) mm. Breslow thicknesses ranged from 0.66 to 5.35 (mean 3.21) mm, 5 lesions Clark level IV and 4 level V, and dermal mitotic rates varied from 1 to 5 (mean 2.4) per square millimeter. Despite follow-up of 6 months or less in 4 subjects, 5 patients showed regional tumor spread based on detection of SLN deposits, local recurrence, or clinical satellite and LN metastases. Four of 5 patients (80%) undergoing SLN biopsy showed nodal positivity with 2 SLN deposits of >6 mm. Among 4 patients not having SLN biopsy, 1 patient developed local LN metastases after 2 years. We report for the first time angiotropism in ASMN and suggest that such angiotropism seems to correlate with and may explain regional tumor spread in this neoplastic system.

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“…As we have described various authors have reviewed their own series of 'Spitz nevi' and accordingly formulated their 'criteria' from these self-selected (and consequently biased) series of lesions (Table 2). 7,11,12,26 The inherent flaws resulting from this exercise involve circular reasoning, the cases in general have not been population-based, the number of cases has often not been adequate, and the cases have not had long-term follow-up (of 8-10 years) to know the outcomes. 22,25,26 Following up on the observations that the vast majority of these Spitzoid lesions do not seem to recur or to metastasize, they have been lumped as a group in benign melanocytic nevi, even though some proportion of lesions seem impossible to distinguish from melanoma and uncommon or rare lesions behave aggressively.…”

mentioning

confidence: 99%

The Spitzoid lesion: rethinking Spitz tumors, atypical variants, ‘Spitzoid melanoma' and risk assessment

2006

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Although much remains to be learned about Spitzoid lesions, there is increasing evidence that these tumors may be a type of melanocytic neoplasm distinct from conventional melanocytic nevi and malignant melanoma. In the current communication, the author has attempted to describe accurately the state-of-the-art surrounding these lesions, their nomenclature, and assessment of risk. Acknowledging the peculiar nature of Spitzoid lesions, the author prefers the term Spitz tumor rather than 'Spitz nevus' (except perhaps for the most typical lesions) and argues against using the term 'Spitzoid melanoma' until more information is available to justify such a term. The author also believes that patients are best served by the comprehensive evaluation of Spitzoid lesions and their classification into three categories: (1) Spitz tumor without significant abnormality, (2) Spitz tumor with one or more atypical features (atypical Spitz tumor), including those judged to have indeterminate biological potential, and (3) malignant melanoma, rather than the two categories of 'Spitz nevus' and melanoma. Only rigorous characterization of sufficient numbers of Spitzoid lesions and long-term follow-up of patients will provide truly objective information for the formulation of optimal guidelines for the management of patients with these lesions.

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Spindle cell nevi and epithelioid cell nevi (so-called juvenile melanomas) in children and adults.A clinicopathological study of 27 cases

Cited by 140 publications

References 21 publications

Clinical and Histopathology Features of Spitz Nevus: In 22 Cases

Clinical and Histopathology Features of Spitz Nevus: In 22 Cases

Atypical Spitzoid Melanocytic Neoplasms With Angiotropism: A Potential Mechanism of Locoregional Involvement

The Spitzoid lesion: rethinking Spitz tumors, atypical variants, ‘Spitzoid melanoma' and risk assessment

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