Spindle cell oncocytoma of the adenohypophysis: Report of a case with a 16-year follow-up

Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893

“…Only 1 pathologically documented case of pituicytoma 56 and 3 cases of GCT 36,39,44 had DI. Similarly, increased levels of prolactin were reported for only 1 case of pituicytoma, 55 2 cases of SCO, 64,70 and 4 cases of GCT. 11,17,22,31 Galactorrhea was reported only in 1 case of GCT.…”

“…69,70 Therefore, if imaging localizes a tumor to the neurohypophysis, the diagnosis of SCO may be excluded. Moreover, all cases of SCO were infiltrating and none could be seen separately from the pituitary gland itself.…”

An Unusual Oncocytic Sellar Neoplasm in a Patient with Birt-Hogg-Dubé Syndrome

“…Although typically described as positive in SCO, galectin-3 is generally not useful in the workup of primary sellar neoplasms, as pituicytoma, meningioma, nerve sheath tumors, granular cell tumor, and even metastases have consistently expressed galectin-3 (Rodriguez et al, 2008). The cases in which bcl2 immunohistochemistry has been performed on SCO have largely showed negative expression; however there are two previously reported cases besides our case with immunopositivity for bcl2 (Vajtai et al, 2006;Vajtai, Beck, Kappeler, & Hewer, 2011). …”

“…Spindle cell oncocytoma of the adenohypophysis is a rare and diagnostically challenging entity with only twenty-four cases reported in the English literature since the first account in 2002 by Roncaroli et al, (Alexandrescu, Brown, Tandon, & Bhattacharjee, 2012;Borges, Lillehei, & KleinschmidtDeMasters, 2011;Borota et al, 2009;Coire, Horvath, Smyth, & Kovacs, 2009;Dahiya et al, 2005;Demssie et al, 2011;Farooq, Bhatt, & Chang, 2008;Fujisawa et al, 2012;Fuller, Scheithauer, Roncaroli, & Wesseling P, 2007;Kloub, Perry, Tu, Lipper, & Lopes, 2005;Matyja et al, 2010;Mlika et al, 2011;Ogiwara, Dubner, Shafizadeh, Raizer, & Chandler, 2011;Romero-Rojas et al, 2011;Roncaroli et al, 2002;Singh et al, 2012;Vajtai, Sahli, & Kappeler, 2006). The classical histologic description of SCO is that of a fascicular neoplasm arising from the adenohypophysis and composed of spindled and epithelial oncocytic cells with immunohistochemical positivity for S100, vimentin, EMA, galectin-3, and antimitochondrial antibodies (Roncaroli et al, 2002).…”

Spindle Cell Oncocytoma of the Adenohypophysis With Marked Hypervascularity

“…MIB-1 index was 3% (D: original magnification ×100). [1][2][3][4]8,9,11,12) The clinical and radiological features of SCO are nonspecific and indistinguishable from those of non-functioning macroadenoma, but its histological profile is quite different; the tumor consists of interwoven fascicles of spindle cells exhibiting abundant eosinophilic cytoplasm, rare mitosis, but no necrosis. The tumor cells show immunoreactivity for vimentin, S-100 protein, and epithelial membrane antigen (EMA), and the cytoplasm contains abundant mitochondria.…”