Spindle cell sarcoma of the right atrium causing right atrial pseudoaneurysm: a case report and review of the literature

Wang, Xiaofang; Dong, Aiqiang; Wei-jun, Yang; Duan, Qun-Jun

doi:10.1186/s13019-021-01404-2

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Most of the reported cases of cardiac spindle cell tumors have been related to sarcoma [ 20 – 22 ]. To our knowledge, this was the first case of myxoid type in cardiac tissue.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Myxoid Spindle Cell Tumor in a Neonate

Abbaszadeh,

Naderi,

Jalali

et al. 2024

Case Reports in Pediatrics

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Introduction: Different subtypes of cardiac tumors containing spindle cells have been described as cardiac sarcoma. However, benign types have not been reported so far. We described a neonate with progressive respiratory distress who had a PDA and was finally diagnosed with a right atrial spindle cell tumor. Case Presentation: The patient was a neonate referred with respiratory distress and sepsis. The initial echocardiography demonstrated a small atrial septal defect, patent ductus arteriosus, and a heterogeneous rounded right atrial mass lesion. Pathologic examination confirmed the right atrial myxoid spindle cell tumor without local invasion. Successful mass resection was performed, and follow‐up echocardiography revealed normal cardiac structure and function. Conclusion: In infants with manifestations of possible cardiac anomalies, it is necessary to consider other pathologies, such as neoplastic processes. Spindle cell detection in pathology is not ominous all the time, and there are benign subtypes with favorable outcomes after successful surgical resection.

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“…Most of the reported cases of cardiac spindle cell tumors have been related to sarcoma [ 20 – 22 ]. To our knowledge, this was the first case of myxoid type in cardiac tissue.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Myxoid Spindle Cell Tumor in a Neonate

Abbaszadeh,

Naderi,

Jalali

et al. 2024

Case Reports in Pediatrics

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Establishment and validation of nomogram models for overall survival and cancer-specific survival in spindle cell sarcoma patients

Qi,

Ren,

Wang

et al. 2023

Sci Rep

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Spindle cell sarcoma (SCS) is rare in clinical practice. The objective of this study was to establish nomograms to predict the OS and CSS prognosis of patients with SCS based on the Surveillance, Epidemiology, and End Results (SEER) database. The data of patients with SCS between 2004 and 2020 were extracted from the SEER database and randomly allocated to a training cohort and a validation cohort. Univariate and multivariate Cox regression analyses were used to screen for independent risk factors for both overall survival (OS) and cancer-specific survival (CSS). Nomograms for OS and CSS were established for patients with SCS based on the results of multivariate Cox analysis. Then, we validated the nomograms by the concordance index (C-index), receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). Finally, Kaplan‒Meier curves and log-rank tests were applied to compare patients with SCS at three different levels and in different treatment groups. A total of 1369 patients with SCS were included and randomly allocated to a training cohort (n = 1008, 70%) and a validation cohort (n = 430, 30%). Age, stage, grade, tumour location, surgery, radiation and diagnosis year were found to be independent prognostic factors for OS by Cox regression analysis, while age, stage, grade, tumour location and surgery were found to be independent prognostic factors for CSS. The nomogram models were established based on the results of multivariate Cox analysis for both OS and CSS. The C-indices of the OS model were 0.76 and 0.77 in the training and validation groups, respectively, while they were 0.76 and 0.78 for CSS, respectively. For OS, the 3- and 5-year AUCs were 0.801 and 0.798, respectively, in the training cohort and 0.827 and 0.799, respectively, in the validation cohort; for CSS, they were 0.809 and 0.786, respectively, in the training cohort and 0.831 and 0.801, respectively, in the validation cohort. Calibration curves revealed high consistency in both OS and CSS between the observed survival and the predicted survival. In addition, DCA was used to analyse the clinical practicality of the OS and CSS nomogram models and revealed that they had good net benefits. Surgery remains the main treatment method for SCS patients. The two nomograms we established are expected to accurately predict the personalized prognosis of SCS patients and may be useful for clinical decision-making.

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Establishment and validation of nomogram models for overall survival (OS) and cancer-specific survival (CSS) of patients with spindle cell sarcoma (SCS): A SEER database analysis.

qi,

Ren,

Wang

et al. 2023

Preprint

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Background Spindle cell sarcoma (SCS) is rare in clinical practice. The purpose of this study was to establish the nomograms to predict the OS and CSS prognosis of patients with SCS based on the Surveillance, Epidemiology, and End Results (SEER) database. Methods The data of patients with SCS were extracted from the SEER database between 2004 and 2020, and randomly allocated to the training cohort and validation cohort. Univariate and multivariate Cox regression analysis are used to screen for independent risk factors both in overall survival (OS) and cancer-specific survival (CSS). Nomograms for OS and CSS were established for patients with SCS based on the results of multivariate cox analysis. Then we validated the nomograms by Concordance index (C-index), receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). Finally, the Kaplan-Meier curve and log-rank test were performed to compare between the patients with SCS in three different levels and different treatment groups. Results A total 1369 patients with SCS were included and randomly divided into the training cohort (n = 961, 70%) and validation cohort (n = 408, 30%). Age, M, tumor size, tumor location, surgery and radiation were independent prognostic factors for OS, while Age, N, M, tumor size, tumor location and surgery for CSS by Cox regression analysis. The nomogram models were established based on the result of the Multiple Cox analysis both in OS and CSS. The C-index of the OS model was 0.79 and 0.77 in the training and validation group, while 0.80 and 0.78 for CSS. The 3/5-year AUCs were 0.817 and 0.824 for the training group and 0.798 and 0.792 for the validation group for OS, while 0.829 and 0.831 in the training group, 0.814 and 0.791 in the validation group for CSS. calibration curves showed high consistencies between the observed survival and the predicted survival both in OS and CSS. In addition, DCA analyzed the clinical practicality of OS and CSS nomogram models have good net benefit. Conclusion The two nomograms we have established are expected to accurately predicting personalized prognosis of SCS patients, which may beneficial for clinical decision-making.

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Spindle cell sarcoma of the right atrium causing right atrial pseudoaneurysm: a case report and review of the literature

Cited by 3 publications

References 12 publications

Cardiac Myxoid Spindle Cell Tumor in a Neonate

Cardiac Myxoid Spindle Cell Tumor in a Neonate

Establishment and validation of nomogram models for overall survival and cancer-specific survival in spindle cell sarcoma patients

Establishment and validation of nomogram models for overall survival (OS) and cancer-specific survival (CSS) of patients with spindle cell sarcoma (SCS): A SEER database analysis.

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