Spindle cell squamous cell carcinoma arising from verrucous hyperplasia during BRAF inhibitor therapy for melanoma

Ziemer, Mirjana; Pönitzsch, Iris; Simon, Jan C.; Schüürmann, Monica

doi:10.1111/ddg.12534

Cited by 7 publications

(6 citation statements)

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“…However, pre-existing skin lesions are not a prerequisite [6]. During targeted therapy of malignant melanoma with BRAF inhibitors verrucous hyperplasia is frequently observed that may develop into well differentiated squamous cell carcinomas of the kerato-acanthoma type [7]. A causative relation of the verrucous carcinoma in our patient and the preceding treatment with ixekizumab is unlikely.…”

Section: Your Diagnosis? … Diagnosis: Verrucous Carcinomamentioning

confidence: 70%

Fast‐growing skin lesion on the lower leg

Vorbeck

Technau‐Hafsi

Eyerich

et al. 2022

J Deutsche Derma Gesell

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We report on a 39-year-old male psoriasis patient that developed a fast-growing skin lesion on his lower leg. The patient was referred to our department due to severe psoriasis (Psoriasis Area and Severity Index [PASI] 26,8) that had proven refractory to previous treatment with fumaric acid esters and methotrexate. As secondary diagnosis, the patient suffered from a prominent verrucous inflammatory thickening of both lower legs, in line with elephantiasis nostras verrucosa, that had developed as a result of chronic venous insufficiency and lymphedema (Figure 1). A biopsy taken from this hypertrophic area showed papillomatosis cutis lymphostatica (PCL) due to the persistent lymphostasis [1,2].

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Section: Your Diagnosis? … Diagnosis: Verrucous Carcinomamentioning

confidence: 70%

Fast‐growing skin lesion on the lower leg

Vorbeck

Technau‐Hafsi

Eyerich

et al. 2022

J Deutsche Derma Gesell

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“…It shows a predilection for sun-damaged skin of the head and neck area of elderly males in the 7 th and 8 th decade. Cases of development from other skin neoplasia (for example, keratoacanthoma-like SCC and verrucous tumor HPV-induced) in patients under BRAF inhibitors therapy, 6 have been recently reported.…”

Section: Discussionmentioning

confidence: 99%

Bleeding and rapidly growing nodule on the forearm of an 86‐year‐old woman

Mariotti

Corrà

Gemignani

et al. 2023

J Deutsche Derma Gesell

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“…Umgekehrt sind vorbestehende chronische Hautläsionen aber keine Bedingung für das Entstehen eines verrukösen Karzinoms [6]. Verruköse Hyperplasien, aus denen hochdifferenzierte Plattenepithelkarzinome vom Keratoakanthom-Typ entstehen können, werden neuerdings unter der zielgerichteten Therapie des malignen Melanoms mit BRAF-Inhibitoren beobachtet [7].…”

Section: Anamnese Und Klinische Befundeunclassified