Spindle cell variant squamous cell carcinoma of the oral cavity: Case presentation and review of literature

Palla, Benjamin; Suhaym, Omar; Majeed, Nasma K; Garzon, Steven; Callahan, Nicholas

doi:10.1016/j.omsc.2020.100174

Cited by 5 publications

(15 citation statements)

References 15 publications

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“…Epithelial markers that show positivity are keratin and epithelial membrane antigen, while mesenchymal markers include vimentin, desmin and S-100. 7 Aggressive surgical resection is considered a mainstay of treatment for this tumour. Surgery followed by radiotherapy is considered for the best long-term outcome.…”

Section: Descriptionmentioning

confidence: 99%

“…Immunohistochemistry is helpful to know the histiogenesis of the spindle cell in this tumour. Epithelial markers that show positivity are keratin and epithelial membrane antigen, while mesenchymal markers include vimentin, desmin and S-100 7…”

Section: Descriptionmentioning

confidence: 99%

“…There is a noticeable difference in prognosis and overall survival of spindle cell carcinoma compared with SCC. The incidence of metastasis is 36%, and about 30% of all oral cases ended with mortality within 1 year 7 8…”

Section: Descriptionmentioning

confidence: 99%

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Spindle cell carcinoma of tongue

et al. 2021

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Section: Descriptionmentioning

confidence: 99%

Section: Descriptionmentioning

confidence: 99%

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Spindle cell carcinoma of tongue

et al. 2021

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“…On histology, the neoplasm presents with epithelial squamous cells and mesenchymal spindle cells that commonly arise in the nasopharynx and oral mucosa. 1 Risk factors for developing OCSCC include alcohol use, tobacco use, poor oral hygiene, and previous irradiation to the head and neck region. 2 We now report a case of a 56-year-old female who presented with severe complications post-OCSCC resection surgery.…”

Section: Introductionmentioning

confidence: 99%

Tracheal Rupture After Tracheostomy Tube Exchange in a Patient With Recurrent Oral Cavity Spindle Cell Carcinoma

et al. 2022

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Oral Cavity Spindle Cell Carcinoma (OCSCC) is a rare variant of squamous cell carcinoma involving the nasopharynx and oral mucosa. This tumor has a high propensity to invade local structures of the head and neck region, making surgical removal challenging and potentially morbid for the patient. Here, we report a case of OCSCC and the complications that were confronted during its surgical resection. Additionally, a review of the literature regarding OCSCC complications and their treatments was performed.

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“…In the upper aerodigestive tract, it is the most common spindle cell lesion arising from the mucosa 4. Larynx is the most common site for spindle cell SCC in the head and neck, followed by the oral cavity 2,5. It comprises around 1% of all oral cavity tumors, with a predilection for the alveolar mucosa, tongue, buccal mucosa, and lower lip 1,5.…”

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confidence: 99%

SATB2 Immunopositivity in Spindle Cell (Sarcomatoid) Squamous Cell Carcinoma: A Potential Pitfall in Diagnosis

Sasidharan¹,

Kakkar²,

Thakar³

et al. 2021

Applied Immunohistochemistry &Amp; Molecular Morphology

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Spindle cell squamous cell carcinomas (SpSCC) are aggressive neoplasms constituting 1% of oral cavity tumors. A proportion of SpSCC do not stain with epithelial markers, and frequently express mesenchymal markers, viz. Vimentin, smooth muscle actin, muscle specific actin, S100 and desmin, confounding the diagnosis. Immunoexpression of SATB2, a transcription factor indicating osteoblastic lineage, has not been evaluated in SpSCC previously. We therefore performed SATB2 immunohistochemistry in 15 cases of SpSCCs and scored them with respect to intensity and percentage of tumor cells stained. SATB2 immunopositivity was identified in 9/15 (60%) SpSCCs, with varying intensity and distribution. Eight cases (53.3%) showed nonfocal staining of moderate to strong intensity, and 1 case (6.7%) showed focal weak staining. Of these, 3 cases (3/9; 33.33%) did not stain with epithelial/squamous markers. Thus, a subset of SpSCC demonstrate SATB2 immunopositivity. In oral tumors with bone involvement, SATB2 positivity may lead away from the diagnosis of SpSCC. Knowledge of this aberrant immunostaining is, therefore, extremely relevant to guard against misdiagnosis as osteosarcoma, particularly on biopsies which lack adjacent dysplastic epithelium, in cases which are monophasic spindle cell, and in those that do not show immunopositivity for epithelial/ squamous markers. Our results emphasize that an appropriate panel and not a single immunomarker is required to distinguish SpSCC from mesenchymal tumors including osteosarcoma.

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Spindle cell variant squamous cell carcinoma of the oral cavity: Case presentation and review of literature

Cited by 5 publications

References 15 publications

Spindle cell carcinoma of tongue

Spindle cell carcinoma of tongue

Tracheal Rupture After Tracheostomy Tube Exchange in a Patient With Recurrent Oral Cavity Spindle Cell Carcinoma

SATB2 Immunopositivity in Spindle Cell (Sarcomatoid) Squamous Cell Carcinoma: A Potential Pitfall in Diagnosis

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