Spindly switch controls anaphase: Spindly and RZZ functions in chromosome attachment and mitotic checkpoint control

Barišić, Marin; Geley, Stephan

doi:10.4161/cc.10.3.14759

Cited by 28 publications

(21 citation statements)

References 94 publications

(149 reference statements)

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“…This elegant mechanism is not universal, however, because dynein does not localize to kinetochores in all eukaryotes. In addition, depletion of Spindly, the dynein receptor, does not completely prevent Mad1/2 removal, suggesting that Spindly may normally supersede an additional conserved removal pathway 98,100 . Interestingly, proteins of the centromere-proximal kinetochore subcomplex CCAN/COMA appear to have a role in opposing dynein stripping, as depletion of the CCAN protein CENP-I greatly enhances the rate of Mad1 dissociation 101,102 .…”

Section: Part I - Kinetochore Activation Of the Checkpointmentioning

confidence: 99%

“…Dynein localizes to the kinetochore through RZZ/Spindly and microtubule association allows dynein to transport this module to the spindle pole. Mad1/2 and BubR1 are also removed by dynein during this process, coupling microtubule binding to stripping of kinetochore checkpoint proteins 97,98-100 . This elegant mechanism is not universal, however, because dynein does not localize to kinetochores in all eukaryotes.…”

Section: Part I - Kinetochore Activation Of the Checkpointmentioning

confidence: 99%

See 1 more Smart Citation

Signalling dynamics in the spindle checkpoint response

London

Biggins

2014

Nat Rev Mol Cell Biol

299

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Section: Part I - Kinetochore Activation Of the Checkpointmentioning

confidence: 99%

Section: Part I - Kinetochore Activation Of the Checkpointmentioning

confidence: 99%

Signalling dynamics in the spindle checkpoint response

London

Biggins

2014

Nat Rev Mol Cell Biol

299

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“…Spindly (also called Ccdc99) plays a central role in silencing the spindle assembly checkpoint (Griffis et al 2007), a mitotic checkpoint that persists until all spindle microtubules become attached to kinetochores (Barisic & Geley 2011). Spindly incorporates into the kinetochore via the Rod/ZW10/Zwilch (RZZ) complex and is required to recruit dynein to kinetochores (Chan et al 2009, Gassmann et al 2008, Griffis et al 2007).…”

Section: How Is Dynein-based Transport Initiated and Activated?mentioning

confidence: 99%

Mechanism and Regulation of Cytoplasmic Dynein

Cianfrocco

DeSantis

Leschziner

et al. 2015

Annu. Rev. Cell Dev. Biol.

225

239

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Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth of new structural, mechanistic, and cell biological data is shedding light on how this complicated minus-end–directed, microtubule-based motor works. Cytoplasmic dynein-1 performs a wide array of functions in most eukaryotes, both in interphase, in which it transports organelles, proteins, mRNAs, and viruses, and in mitosis and meiosis. Mutations in dynein or its regulators are linked to neurodevelopmental and neurodegenerative diseases. Here, we begin by providing a synthesis of recent data to describe the current model of dynein’s mechanochemical cycle. Next, we discuss regulators of dynein, with particular focus on those that directly interact with the motor to modulate its recruitment to microtubules, initiate cargo transport, or activate minus-end–directed motility.

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“…6,7 The RZZ complex is bound to the dynein motor through an adaptor protein called Spindly. 53 Spindly is recruited to kinetochores by the RZZ complex and there is evidence for a weak interaction between them in both C. elegans and human cells. 54 Although Dynein and Spindly are responsible for stripping the SAC components leading to SAC inactivation, the precise mechanism is unclear.…”

Section: Integration Of the Kmn Network With Sac Silencingmentioning

confidence: 99%

How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling

Agarwal

Varma

2015

BioArchitecture

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ABSTRACT. Mitosis entails the bona fide segregation of duplicated chromosomes. This process is accomplished by the attachment of kinetochores on chromosomes to microtubules (MTs) of the mitotic spindle. Once the appropriate attachment is achieved, the spindle assembly checkpoint (SAC) that delays the premature onset of anaphase needs to be silenced for the cell to proceed to anaphase and cytokinesis. Therefore, while it is imperative to preserve the SAC when kinetochores are unattached, it is of paramount importance that SAC components are removed post kinetochore microtubule (kMT) attachment. Precise knowledge of how kMT attachments trigger the removal of SAC components from kinetochores or how the checkpoint proteins feedback in to the attachment machinery remains elusive. This review aims to describe the recent advances that provide an insight into the interplay of molecular events that coordinate and regulate the SAC activity in response to kMT attachment during cell division.

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Spindly switch controls anaphase: Spindly and RZZ functions in chromosome attachment and mitotic checkpoint control

Cited by 28 publications

References 94 publications

Signalling dynamics in the spindle checkpoint response

Signalling dynamics in the spindle checkpoint response

Mechanism and Regulation of Cytoplasmic Dynein

How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling

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