Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers

Zhao, Chunjiang; Jou, Jessica; Wolff, Lisa J.; Sun, Hui; Gage, Fred H.

doi:10.1002/cne.23800

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…We found that repeated phase advances increased the proportion of early stage post-mitotic DCX + cells (stages 1 and 2) but decreased the proportion of late stage DCX + cells (stages 5 and 6). Late stage DCX + cells are characterized by the growth of established dendritic processes that extend into the inner and outer molecular layer, and this phase of development is associated with intense spine synapse formation and circuit integration (Zhao et al, 2006(Zhao et al, , 2015Toni and Sultan, 2011;Vivar and Van Praag, 2013;Radic et al, 2015;Beining et al, 2017;Petsophonsakul et al, 2017). The potential loss of the later stage DCX + cells, but not early stage DCX cells could suggest that chronic phase advancements might interfere with processes associated with cell maturation and/or survival as we observed a net decrease in the number of DCX + cells in this group.…”

Section: Impact Of Chronic Jet Lag On Hippocampal Neurogenesismentioning

confidence: 99%

Chronic Jet Lag Simulation Decreases Hippocampal Neurogenesis and Enhances Depressive Behaviors and Cognitive Deficits in Adult Male Rats

Horsey

Maletta

Turner

et al. 2020

Front. Behav. Neurosci.

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There is a long history that protracted periods of circadian disruption, such as through frequent transmeridian travel or rotating shift work, can have a significant impact on brain function and health. In addition, several studies have shown that chronic periods of circadian misalignment can be a significant risk factor for the development of depression and anxiety in some individuals with a history of psychiatric illness. In animal models, circadian disruption can be introduced through either phase advances or delays in the light-dark cycle. However, the impact of chronic phase shifts on affective behavior in rats has not been well-studied. In the present study, male rats were subjected to either weekly 6 h phase advances (e.g., traveling eastbound from New York to Paris) or 6 h phase delays (e.g., traveling westbound from New York to Hawaii) in their light/dark cycle for 8 weeks. The effect of chronic phase shifts was then examined on a range of emotional and cognitive behaviors. We found that rats exposed to frequent phase advances, which mirror conditions of chronic jet lag in humans, exhibited impairments in object recognition memory and showed signature symptoms of depression, including anhedonia, increased anxiety behavior, and higher levels of immobility in the forced swim test. In addition, rats housed on the phase advance schedule also had lower levels of hippocampal neurogenesis and immature neurons showed reduced dendritic complexity compared to controls. These behavioral and neurogenic changes were direction-specific and were not observed after frequent phase delays. Taken together, these findings support the view that circadian disruption through chronic jet lag exposure can suppress hippocampal neurogenesis, which can have a significant impact on memory and mood-related behaviors.

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Section: Impact Of Chronic Jet Lag On Hippocampal Neurogenesismentioning

confidence: 99%

Chronic Jet Lag Simulation Decreases Hippocampal Neurogenesis and Enhances Depressive Behaviors and Cognitive Deficits in Adult Male Rats

Horsey

Maletta

Turner

et al. 2020

Front. Behav. Neurosci.

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“…Along with the genetic effects, neuronal maturation and integration are essential for portraying the benefits of EE. The experience of the animal leads to differing synaptogenesis and dendritic spine formation in the dentate gyrus (DG) during neurogenesis ( Zhao et al, 2015 ). New neurons need stimulation to mature into tissue-specific neurons that are capable of remaining viable.…”

Section: Enriched Environment/exercise and Pathologymentioning

confidence: 99%

Enriched Environment and Exercise Enhance Stem Cell Therapy for Stroke, Parkinson’s Disease, and Huntington’s Disease

Berlet

Cabantan

Gonzales-Portillo

et al. 2022

Front. Cell Dev. Biol.

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Stem cells, specifically embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), induced pluripotent stem cells (IPSCs), and neural progenitor stem cells (NSCs), are a possible treatment for stroke, Parkinson’s disease (PD), and Huntington’s disease (HD). Current preclinical data suggest stem cell transplantation is a potential treatment for these chronic conditions that lack effective long-term treatment options. Finding treatments with a wider therapeutic window and harnessing a disease-modifying approach will likely improve clinical outcomes. The overarching concept of stem cell therapy entails the use of immature cells, while key in recapitulating brain development and presents the challenge of young grafted cells forming neural circuitry with the mature host brain cells. To this end, exploring strategies designed to nurture graft-host integration will likely enhance the reconstruction of the elusive neural circuitry. Enriched environment (EE) and exercise facilitate stem cell graft-host reconstruction of neural circuitry. It may involve at least a two-pronged mechanism whereby EE and exercise create a conducive microenvironment in the host brain, allowing the newly transplanted cells to survive, proliferate, and differentiate into neural cells; vice versa, EE and exercise may also train the transplanted immature cells to learn the neurochemical, physiological, and anatomical signals in the brain towards better functional graft-host connectivity.

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Prenatal alcohol exposure alters synaptic activity of adult hippocampal dentate granule cells under conditions of enriched environment

et al. 2016

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Prenatal alcohol exposure (PAE) results in fetal alcohol spectrum disorder (FASD), which is characterized by a wide range of cognitive and behavioral deficits that may be linked to impaired hippocampal function and adult neurogenesis. Preclinical studies in mouse models of FASD indicate that PAE markedly attenuates enrichment-mediated increases in the number of adult-generated hippocampal dentate granule cells (aDGCs), but whether synaptic activity is also affected has not been studied. Here, we utilized retroviral birth-dating coupled with whole cell patch electrophysiological recordings to assess the effects of PAE on enrichment-mediated changes in excitatory and inhibitory synaptic activity as a function of DGC age. We found that exposure to an enriched environment (EE) had no effect on baseline synaptic activity of 4 week or 8 week old aDGCs from control mice, but significantly enhanced the excitatory/inhibitory ratio of synaptic activity in 8 week old aDGCs from PAE mice. In contrast, exposure to EE significantly enhanced the excitatory/inhibitory ratio of synaptic activity in older pre-existing DGCs situated in the outer dentate granule cell layer (i.e., those generated during embryonic development; dDGCs) in control mice, an effect that was blunted in PAE mice. These findings indicate distinct electrophysiological responses of hippocampal DGCs to behavioral challenge based on cellular ontogenetic age, and suggest that PAE disrupts EE-mediated changes in overall hippocampal network activity. These findings may have implications for future therapeutic targeting of hippocampal dentate circuitry in clinical FASD.

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Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers

Cited by 5 publications

References 21 publications

Chronic Jet Lag Simulation Decreases Hippocampal Neurogenesis and Enhances Depressive Behaviors and Cognitive Deficits in Adult Male Rats

Chronic Jet Lag Simulation Decreases Hippocampal Neurogenesis and Enhances Depressive Behaviors and Cognitive Deficits in Adult Male Rats

Enriched Environment and Exercise Enhance Stem Cell Therapy for Stroke, Parkinson’s Disease, and Huntington’s Disease

Prenatal alcohol exposure alters synaptic activity of adult hippocampal dentate granule cells under conditions of enriched environment

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